ChemicalBook > CAS DataBase List > 4-Bromo-2-fluorophenol

4-Bromo-2-fluorophenol

Product Name
4-Bromo-2-fluorophenol
CAS No.
2105-94-4
Chemical Name
4-Bromo-2-fluorophenol
Synonyms
4-Bromo-2-fluorophen;4-Brom-2-Fluorphenol;2-Fluor-4 bromophenol;2-Fluoro-4-BroMophonel;2-Fluoro-4-Bromophenol;4-BROMO-2-FLUOROPHENOL;2-Bromo-2-fluorophenol;4-Bromo-2-fluorophenol98%;Phenol, 4-bromo-2-fluoro-;4-Bromo-2-fluorophenol >
CBNumber
CB6257615
Molecular Formula
C6H4BrFO
Formula Weight
191
MOL File
2105-94-4.mol
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4-Bromo-2-fluorophenol Property

Boiling point:
79 °C/7 mmHg (lit.)
Density 
1.744 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.566(lit.)
Flash point:
210 °F
storage temp. 
Inert atmosphere,Room Temperature
form 
Liquid
pka
8.14±0.18(Predicted)
Specific Gravity
1.744
color 
Clear colorless to brown
BRN 
1861281
InChI
InChI=1S/C6H4BrFO/c7-4-1-2-6(9)5(8)3-4/h1-3,9H
InChIKey
RYVOZMPTISNBDB-UHFFFAOYSA-N
SMILES
C1(O)=CC=C(Br)C=C1F
CAS DataBase Reference
2105-94-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-37/39-36/37/39
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29071990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
316296
Product name
4-Bromo-2-fluorophenol
Purity
98%
Packaging
5g
Price
$25
Updated
2023/01/07
Sigma-Aldrich
Product number
316296
Product name
4-Bromo-2-fluorophenol
Purity
98%
Packaging
25g
Price
$60.8
Updated
2023/01/07
TCI Chemical
Product number
B1835
Product name
4-Bromo-2-fluorophenol
Purity
>98.0%(GC)
Packaging
5g
Price
$31
Updated
2025/07/31
TCI Chemical
Product number
B1835
Product name
4-Bromo-2-fluorophenol
Purity
>98.0%(GC)
Packaging
25g
Price
$92
Updated
2025/07/31
TRC
Product number
B692828
Product name
4-Bromo-2-fluorophenol
Packaging
1g
Price
$55
Updated
2021/12/16
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4-Bromo-2-fluorophenol Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLORLESS TO BROWNISH LIQUID

Uses

4-Bromo-2-fluorophenol can be used as a starting material for the synthesis of:

  • 4-Bromo-2-fluoro-6-iodoanisole via iodination and methylation.
  • 2-Phenylpyran-4-ones for active cyclooxygenase-2 inhibitor evaluation.
  • 1,4-Disubstituted 3-cyano-2-pyridones.
  • Dicationic imidazolium-based compounds.

Synthesis

367-12-4

2105-94-4

Example 5: Preparation of methyl 2-[4-(4-bromo-2-fluorophenoxy)phenoxy]propionate (STR29) 1. 2-Fluorophenol (22.4 g, 0.2 mol) was dissolved in dichloromethane (250 mL) under ice bath conditions and cooled to about 3 °C. 2. 2. bromine (31.97 g, 0.2 mol) was added slowly, keeping the reaction temperature at ice bath conditions. 3. the reaction mixture was stirred at ice bath temperature for 2 hours, followed by continued stirring at room temperature for 1 hour. 4. the reaction mixture was quenched by pouring into water (600 mL) containing excess sodium bisulfite. 5. The organic phase was separated and the aqueous phase was washed with additional dichloromethane (200 mL). 6. The organic extracts were combined, washed with saturated sodium bicarbonate solution and subsequently dried over anhydrous magnesium sulfate. 7. The solvent was removed by evaporation to afford the target product 2-fluoro-4-bromophenol as a colorless oil (34.5 g, 90% yield). 8. The structure of the product was confirmed to be as expected by NMR hydrogen spectroscopy (CDCl3).

References

[1] Patent: US4642338, 1987, A
[2] Patent: US4725683, 1988, A
[3] Patent: US4808750, 1989, A
[4] Patent: US4550192, 1985, A
[5] Chemistry - A European Journal, 2017, vol. 23, # 5, p. 1044 - 1047

4-Bromo-2-fluorophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Bromo-2-fluorophenol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd
Product
4-Bromo-2-fluorophenol 2105-94-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-24
Shaanxi Dideu New Materials Co. Ltd
Product
4-Bromo-2-fluorophenol 2105-94-4
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-03-21
Hebei Yanxi Chemical Co., Ltd.
Product
4-Bromo-2-fluorophenol 2105-94-4
Price
US $10.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
10 tons
Release date
2023-10-23

2105-94-4, 4-Bromo-2-fluorophenolRelated Search:

3-Fluorophenol 3-Trifluoromethylphenol 2-Bromophenol 4-Bromo-2-fluorobenzoic acid 4-Bromophenol 4-Fluorophenol 4-Trifluoromethylphenol 3-Bromophenol 4-BROMO-2-CHLORO-6-FLUOROPHENOL 4-BROMO-2-CHLORO-6-FLUOROANISOLE 4-Bromo-2-fluoro-6-nitrophenol 4-Bromo-2,5-difluoroanisole 2-(4'-BROMO-2'-FLUOROPHENOXY)PROPANE 4-Bromo-2,6-difluoroanisole 4-BROMO-2,6-DIFLUOROPHENOL 4-Bromo-2-fluoroanisole 2,4-DIBROMO-6-FLUOROPHENOL Bromine

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  • 4-Bromo-2-fluorophenol ISO 9001：2015 REACH
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  • 2-Bromo-2-fluorophenol
  • 2105-94-4
  • 2105-94-9
  • 2015-94-4
  • 2195-94-4
  • BrC6H3FOH
  • C6H4BrFO
  • Building Blocks for Liquid Crystals
  • Phenols (Building Blocks for Liquid Crystals)
  • Building Blocks
  • Organic Building Blocks
  • Oxygen Compounds
  • Phenols
  • alcohol| alkyl bromide|alkyl Fluorine
  • Building Blocks for Liquid Crystals
  • Functional Materials
  • Phenols (Building Blocks for Liquid Crystals)
  • Organic Building Blocks
  • Oxygen Compounds
  • Fluorobenzene
  • Phenol&Thiophenol&Mercaptan
  • Bromine Compounds
  • Fluorine Compounds
  • Phenols
  • Aromatic Phenols
  • Fluorobenzene Series
  • bc0001