ChemicalBook > CAS DataBase List > NSC 42834

NSC 42834

Product Name
NSC 42834
CAS No.
195371-52-9
Chemical Name
NSC 42834
Synonyms
NSC 42834;1-Butanone;NSC 42834，Z3;Z3(NSC 42834);JAK2 Inhibitor V;NSC 42834,Z3, >95%;JAK2 Inhibitor V, Z3;JAK2 Inhibitor V Z3|||Z3;JAK2 Inhibitor V, Z3, >=98%;NSC 42834 (JAK2 INHIBITOR V)
CBNumber
CB62645144
Molecular Formula
C23H24N2O
Formula Weight
344.45
MOL File
195371-52-9.mol
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NSC 42834 Property

Boiling point:
520.4±50.0 °C(Predicted)
Density 
1.106±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMF: 30 mg/ml; DMSO: 20 mg/ml; Ethanol: 30 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form 
Powder
pka
5.90±0.12(Predicted)
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
420141
Product name
JAK2 Inhibitor V, Z3 - CAS 195371-52-9 - Calbiochem
Packaging
10MG
Price
$154
Updated
2023/01/07
Cayman Chemical
Product number
17684
Product name
JAK2 Inhibitor V
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
17684
Product name
JAK2 Inhibitor V
Purity
≥95%
Packaging
5mg
Price
$78
Updated
2024/03/01
Cayman Chemical
Product number
17684
Product name
JAK2 Inhibitor V
Purity
≥95%
Packaging
10mg
Price
$122
Updated
2024/03/01
Cayman Chemical
Product number
17684
Product name
JAK2 Inhibitor V
Purity
≥95%
Packaging
25mg
Price
$267
Updated
2024/03/01
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NSC 42834 Chemical Properties,Usage,Production

Uses

NSC 42834 (JAK2 Inhibitor V), a novel specific inhibitor of Jak2, inhibits Jak2-V617F and Jak2-WT autophosphorylation in a dose-dependent manner but was not cytotoxic to cells at concentrations that inhibited kinase activity.

IC 50

JAK2-WT: 15 μM (IC50); JAK2-V617F: 28 μM (IC50)

References

[1] Jacqueline Sayyah, Andrew Magis, David A. Ostrov, et al. Z3, a novel Jak2 tyrosine kinase small-molecule inhibitor that suppresses Jak2-mediated pathologic cell growth . Mol Cancer Ther 2008;7(8):2308-18.
[2] Jacqueline Sayyah, Peter P. Sayeski. Jak2 inhibitors: Rationale and role as therapeutic agents in hematologic malignancies. Current Oncology Reports. 2009, 11(2): 117-124.
[3] Ehab Atallah , Srdan Verstovsek . Prospect of JAK2 inhibitor therapy in myeloproliferative neoplasms. Expert Review of Anticancer Therapy. 2009,9 (5):663-670.

NSC 42834 Preparation Products And Raw materials

Raw materials

Preparation Products

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NSC 42834 Suppliers

China 81 India 1 United States 14 Global 96
A.J Chemicals
Tel
--
Fax
--
Email
sales@ajchem.in
Country
India
ProdList
6100
Advantage
58
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View Lastest Price from NSC 42834 manufacturers

Career Henan Chemical Co
Product
2-METHYL-1-PHENYL-4-(PYRIDIN-2-YL)-2-(2-(PYRIDIN-2-YL)ETHYL)BUTAN-1-ONE 195371-52-9
Price
US $1.00/ASSAYS
Min. Order
1ASSAYS
Purity
98%
Supply Ability
10kg
Release date
2019-09-04

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  • JAK2 Inhibitor V, Z3
  • NSC 42834
  • 1-Butanone, 2-Methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-
  • 2-METHYL-1-PHENYL-4-(PYRIDIN-2-YL)-2-(2-(PYRIDIN-2-YL)ETHYL)BUTAN-1-ONE
  • 2-Methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-1-butanone
  • NSC 42834 2-Methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-1-butanone
  • 1-Butanone
  • 2-methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-
  • Z3;NSC 42834;1-BUTANONE; 2-METHYL-1-PHENYL-4-(2-PYRIDINYL)-2-[2-(2-PYRIDINYL)ETHYL]-
  • NSC 42834 (JAK2 INHIBITOR V)
  • NSC 42834(JAK2 Inhibitor V, Z3)
  • NSC 42834,Z3, >95%
  • JAK2 Inhibitor V, Z3, >=98%
  • JAK2 Inhibitor V
  • NSC 42834 Z 3 2-Methyl-1-phenyl-4-(2-pyridinyl)-2-[2-(2-pyridinyl)ethyl]-1-butanone
  • Z3(NSC 42834)
  • NSC 42834，Z3
  • NSC42834,Z 3,NSC-42834,Janus kinase,NSC 42834,Z-3,Inhibitor,JAK,inhibit
  • JAK2 Inhibitor V Z3|||Z3
  • JAK2 Inhibitor V, 10 mM in DMSO
  • 195371-52-9
  • Inhibitors