ChemicalBook > CAS DataBase List > 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-

2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-

Product Name
2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
CAS No.
1422955-31-4
Chemical Name
2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
Synonyms
HIF-C2;TC-S 7009;HIF-2α-I2;HIF-2 inhibitor 2;HIF-2 Antagonist 2;TCS 7009,TC S 7009;HIF-2α Antagonist 2;HIF Inhibitor VII - Calbiochem;N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine;2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
CBNumber
CB62668459
Molecular Formula
C12H6ClFN4O3
Formula Weight
308.6524432
MOL File
1422955-31-4.mol
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2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- Property

Boiling point:
430.2±55.0 °C(Predicted)
Density 
1.652±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: soluble15mg/mL, clear
form 
Yellow powder
pka
-2.82±0.48(Predicted)
color 
white to beige
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
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Safety

Hazard Codes 
T
Risk Statements 
25
Safety Statements 
45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0883
Product name
HIF-2 Antagonist 2
Purity
≥98% (HPLC)
Packaging
5mg
Price
$118
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0883
Product name
HIF-2 Antagonist 2
Purity
≥98% (HPLC)
Packaging
25mg
Price
$478
Updated
2024/03/01
Sigma-Aldrich
Product number
5.04379
Product name
HIF Inhibitor VII - Calbiochem
Packaging
10MG
Price
$265
Updated
2024/03/01
Tocris
Product number
5243
Product name
TC-S7009
Purity
≥99%(HPLC)
Packaging
5
Price
$87
Updated
2021/12/16
Tocris
Product number
5243
Product name
TC-S7009
Purity
≥99%(HPLC)
Packaging
25
Price
$324
Updated
2021/12/16
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2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- Chemical Properties,Usage,Production

Description

HIF-2α-I2 (1422955-31-4) is a potent and selective HIF-2α inhibitor, Kd=81 nM.1?Binds to the HIF-2α PAS-B domain2?and interferes with Hif-2α / ARNT heterodimerization reducing target gene expression in a cellular model1. Highly selective for HIF-2α displaying a >60-fold selectivity over HIF-1α.1,2

Uses

N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine is a HIF-2α inhibitor which inhibits HIF-2α-ARNT heterodimerization by binding to HIF-2α PAS-B domain. It may be used in therapeutic treatment of HIF-2-driven tumors such as renal cell carcinomas.

storage

Store at RT

References

1) Scheuermann?et al.?(2013),?Allosteric inhibition of hypoxia inducible factor-2 with small molecules; Nat. Chem. Biol.,?9?271 2) Masetti?et al.?(2014),?Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding; PLoS One,?9(4)?e94986 3) Rodgers?et al.?(2013),?Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor; J. Med. Chem.,?56 1739

2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- Preparation Products And Raw materials

Raw materials

Preparation Products

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2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- Suppliers

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1422955-31-4, 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-Related Search:

WY-14643 1-Chloro-3-methanesulfonyl-6,6-dimethyl-6,7-dihydro-5H-benzo[c]thiophen-4-one Pifithrin-μ StaupriMide

  • 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
  • HIF-C2
  • HIF-2 Antagonist 2
  • TC-S 7009
  • N-(3-Chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine
  • HIF-2 inhibitor 2
  • HIF Inhibitor VII - Calbiochem
  • N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine
  • HIF-2α-I2
  • TCS 7009,TC S 7009
  • HIF-2α Antagonist 2
  • 1422955-31-4