2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-

ChemicalBook > CAS DataBase List > 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-

2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-

Product Name: 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
CAS No.: 1422955-31-4
Chemical Name: 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
Synonyms: HIF-C2;TC-S 7009;HIF-2α-I2;HIF-2 inhibitor 2;HIF-2 Antagonist 2;TCS 7009,TC S 7009;HIF-2α Antagonist 2;HIF Inhibitor VII - Calbiochem;N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine;2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
CBNumber: CB62668459
Molecular Formula: C12H6ClFN4O3
Formula Weight: 308.6524432
MOL File: 1422955-31-4.mol

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2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- Property

Boiling point:: 430.2±55.0 °C(Predicted)
Density: 1.652±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: soluble15mg/mL, clear
form: Yellow powder
pka: -2.82±0.48(Predicted)
color: white to beige
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.

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Safety

Hazard Codes: T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0883
Product name: HIF-2 Antagonist 2
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $118
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0883
Product name: HIF-2 Antagonist 2
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $478
Updated: 2024/03/01

Sigma-Aldrich

Product number: 5.04379
Product name: HIF Inhibitor VII - Calbiochem
Packaging: 10MG
Price: $265
Updated: 2024/03/01

Tocris

Product number: 5243
Product name: TC-S7009
Purity: ≥99%(HPLC)
Packaging: 5
Price: $87
Updated: 2021/12/16

Tocris

Product number: 5243
Product name: TC-S7009
Purity: ≥99%(HPLC)
Packaging: 25
Price: $324
Updated: 2021/12/16

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2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- Chemical Properties,Usage,Production

Description

HIF-2α-I2 (1422955-31-4) is a potent and selective HIF-2α inhibitor, Kd=81 nM.1?Binds to the HIF-2α PAS-B domain2?and interferes with Hif-2α / ARNT heterodimerization reducing target gene expression in a cellular model1. Highly selective for HIF-2α displaying a >60-fold selectivity over HIF-1α.1,2

Uses

N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine is a HIF-2α inhibitor which inhibits HIF-2α-ARNT heterodimerization by binding to HIF-2α PAS-B domain. It may be used in therapeutic treatment of HIF-2-driven tumors such as renal cell carcinomas.

storage

Store at RT

References

1) Scheuermann?et al.?(2013),?Allosteric inhibition of hypoxia inducible factor-2 with small molecules; Nat. Chem. Biol.,?9?271 2) Masetti?et al.?(2014),?Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding; PLoS One,?9(4)?e94986 3) Rodgers?et al.?(2013),?Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor; J. Med. Chem.,?56 1739

2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- Preparation Products And Raw materials

Raw materials

Preparation Products

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2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- Suppliers

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1422955-31-4, 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-Related Search:

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2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-

HIF-C2

HIF-2 Antagonist 2

TC-S 7009

N-(3-Chloro-5-fluorophenyl)-4-nitrobenzo[c][1,2,5]oxadiazol-5-amine

HIF-2 inhibitor 2

HIF Inhibitor VII - Calbiochem

N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine

HIF-2α-I2

TCS 7009,TC S 7009

HIF-2α Antagonist 2

1422955-31-4