2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
- Product Name
- 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
- CAS No.
- 1422955-31-4
- Chemical Name
- 2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
- Synonyms
- HIF-C2;TC-S 7009;HIF-2α-I2;HIF-2 inhibitor 2;HIF-2 Antagonist 2;TCS 7009,TC S 7009;HIF-2α Antagonist 2;HIF Inhibitor VII - Calbiochem;N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine;2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro-
- CBNumber
- CB62668459
- Molecular Formula
- C12H6ClFN4O3
- Formula Weight
- 308.6524432
- MOL File
- 1422955-31-4.mol
2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- Property
- Boiling point:
- 430.2±55.0 °C(Predicted)
- Density
- 1.652±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- solubility
- DMSO: soluble15mg/mL, clear
- form
- Yellow powder
- pka
- -2.82±0.48(Predicted)
- color
- white to beige
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
N-Bromosuccinimide Price
- Product number
- SML0883
- Product name
- HIF-2 Antagonist 2
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $118
- Updated
- 2024/03/01
- Product number
- SML0883
- Product name
- HIF-2 Antagonist 2
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $478
- Updated
- 2024/03/01
- Product number
- 5.04379
- Product name
- HIF Inhibitor VII - Calbiochem
- Packaging
- 10MG
- Price
- $265
- Updated
- 2024/03/01
- Product number
- 5243
- Product name
- TC-S7009
- Purity
- ≥99%(HPLC)
- Packaging
- 5
- Price
- $87
- Updated
- 2021/12/16
- Product number
- 5243
- Product name
- TC-S7009
- Purity
- ≥99%(HPLC)
- Packaging
- 25
- Price
- $324
- Updated
- 2021/12/16
2,1,3-Benzoxadiazol-5-aMine, N-(3-chloro-5-fluorophenyl)-4-nitro- Chemical Properties,Usage,Production
Description
HIF-2α-I2 (1422955-31-4) is a potent and selective HIF-2α inhibitor, Kd=81 nM.1?Binds to the HIF-2α PAS-B domain2?and interferes with Hif-2α / ARNT heterodimerization reducing target gene expression in a cellular model1. Highly selective for HIF-2α displaying a >60-fold selectivity over HIF-1α.1,2
Uses
N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine is a HIF-2α inhibitor which inhibits HIF-2α-ARNT heterodimerization by binding to HIF-2α PAS-B domain. It may be used in therapeutic treatment of HIF-2-driven tumors such as renal cell carcinomas.
storage
Store at RT
References
1) Scheuermann?et al.?(2013),?Allosteric inhibition of hypoxia inducible factor-2 with small molecules; Nat. Chem. Biol.,?9?271 2) Masetti?et al.?(2014),?Protein dynamics of the HIF-2α PAS-B domain upon heterodimerization and ligand binding; PLoS One,?9(4)?e94986 3) Rodgers?et al.?(2013),?Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor; J. Med. Chem.,?56 1739