1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

Product Name: 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
CAS No.: 394-32-1
Chemical Name: 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
Synonyms: 1-(5-FLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE;5-FLUORO-2-HYDROXYACETOPHENONE;2-Acety-4-fluorophenol;1-(5-FLUORO-2-HYDROXY-P;2-Acetyl-4-fluorophenol;2-hydroxy-5-fluorophenone;2-HYDROXY-5-FLUOROACETOPHENONE;5'-Fluoro-2'-hydroxyacetopheno;5’-fluoro-2’-hydroxy-acetophenon;5'-FLUORO-2'-HYDROXYACETOPHENONE
CBNumber: CB6267638
Molecular Formula: C8H7FO2
Formula Weight: 154.14
MOL File: 394-32-1.mol

More

Less

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Property

Melting point:: 56-58 °C(lit.)
Boiling point:: 65-66 °C8 mm Hg(lit.)
Density: 1.1850 (estimate)
Flash point:: 65-66°C/8mm
storage temp.: Inert atmosphere,Room Temperature
form: powder to crystal
pka: 10.17±0.18(Predicted)
color: White to Gray to Brown
Water Solubility: Soluble 0.68 G/L
BRN: 2359087
CAS DataBase Reference: 394-32-1(CAS DataBase Reference)
NIST Chemistry Reference: 5-Fluoro-2-hydroxyacetophenone(394-32-1)

More

Less

Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-22
Safety Statements: 26-37/39-36/37/39
WGK Germany: 3
RTECS: AM8502300
HazardClass: IRRITANT
HS Code: 29147000

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 247170
Product name: 5′-Fluoro-2′-hydroxyacetophenone
Purity: 98%
Packaging: 5g
Price: $31.3
Updated: 2024/03/01

Sigma-Aldrich

Product number: 247170
Product name: 5′-Fluoro-2′-hydroxyacetophenone
Packaging: 1g
Price: $28.5
Updated: 2022/05/15

TCI Chemical

Product number: F0318
Product name: 5'-Fluoro-2'-hydroxyacetophenone
Purity: >98.0%(GC)
Packaging: 5g
Price: $35
Updated: 2024/03/01

TCI Chemical

Product number: F0318
Product name: 5'-Fluoro-2'-hydroxyacetophenone
Purity: >98.0%(GC)
Packaging: 25g
Price: $89
Updated: 2024/03/01

Alfa Aesar

Product number: A15614
Product name: 5'-Fluoro-2'-hydroxyacetophenone, 98%
Packaging: 5g
Price: $61.7
Updated: 2021/12/16

More

Less

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Chemical Properties,Usage,Production

Chemical Properties

light yellow to beige-brown crystals

Uses

5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:

1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one
3-hydroxy and 3-methoxyflavones
3-hydroxy and 3-methoxy 2-styrylchromones

Definition

ChEBI: 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone.

Preparation

Preparation by Fries rearrangement of 4-fluorophenyl acetate with aluminium chloride without solvent between 115° and 150° (88–89%).

General Description

5-fluoro-2-hydroxy acetophenone, also known as 2-ethanoyl-4-fluorophenol or 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone, is a kind of important medicine intermediate, can be used as multiple beta-blockers synthetic intermediate, has vast market prospect.

Synthesis

The preparation method of 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone under following steps:
Performing double esterification on amino groups and phenolic hydroxy in one step by taking amino-phenol as a raw material.
Performing Fries rearrangement under the condition of aluminum chloride/sodium chloride.
Heating a hydrolyzate after completing fluorine diazotization to obtain finished 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone.

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Suppliers

Americas 1 Belgium 2 Canada 1 China 258 Europe 5 France 2 Germany 5 India 34 Italy 1 Japan 3 Slovakia 1 Switzerland 3 Ukraine 2 United Kingdom 20 United States 51 Global 389

Apin Chemicals Limited (UK)

Tel: --
Fax: --
Email: info@apinchemicals.com
Country: United Kingdom
ProdList: 6184
Advantage: 60

Melford Laboratories Ltd

Tel: --
Fax: --
Country: United Kingdom
ProdList: 483
Advantage: 58

Apollo Scientific Ltd

Tel: --
Fax: --
Email: ales@apo
Country: United Kingdom
ProdList: 4521
Advantage: 58

Wychem Limited

Tel: --
Fax: --
Email: sales@wychem.co.uk
Country: United Kingdom
ProdList: 736
Advantage: 58

Manchester Organics

Tel: --
Fax: --
Email: info@manchesterorganics.com
Country: United Kingdom
ProdList: 6834
Advantage: 67

Apollo Scientific Ltd.

Tel: --
Fax: --
Email: sales@apolloscientific.co.uk
Country: United Kingdom
ProdList: 6084
Advantage: 88

Melford Laboratories Ltd.

Tel: --
Fax: --
Email: sales@melford.co.uk
Country: United Kingdom
ProdList: 1516
Advantage: 64

Key Organics Limited/Bionet Research

Tel: --
Fax: --
Email: enquiries@keyorganics.ltd.uk
Country: United Kingdom
ProdList: 6663
Advantage: 50

Leancare Ltd.

Tel: --
Fax: --
Email: enquiry@leancare.co.uk
Country: United Kingdom
ProdList: 6446
Advantage: 42

MOLEKULA Ltd.

Tel: --
Fax: --
Email: kevinbanks@molekula.com
Country: United Kingdom
ProdList: 6140
Advantage: 66

CARBONE SCIENTIFIC CO.,LTD

Tel: --
Fax: --
Email: sales@carbonesci.com
Country: United Kingdom
ProdList: 6666
Advantage: 30

UK GREEN SCIENTIFIC CO.,LIMITED

Tel: --
Fax: --
Email: sales@gs-chem.com
Country: United Kingdom
ProdList: 6098
Advantage: 47

Fluorochem Ltd

Tel: --
Fax: --
Email: vernam@fluorochem.co.uk
Country: United Kingdom
ProdList: 6375
Advantage: 65

Wychem Ltd.

Tel: --
Fax: --
Email: terry.robinson@wychem.co.uk
Country: United Kingdom
ProdList: 1995
Advantage: 47

MDA Chemicals Ltd.

Tel: --
Fax: --
Email: sheila@mda-chem.co.uk
Country: United Kingdom
ProdList: 1961
Advantage: 30

Eurolabs Limited

Tel: --
Fax: --
Country: United Kingdom
ProdList: 6309
Advantage: 46

Fulcrum Scientific Ltd.

Tel: --
Fax: --
Country: United Kingdom
ProdList: 6565
Advantage: 38

Fluorochem Ltd.

Tel: --
Fax: --
Email: enquiries@fluorochem.co.uk
Country: United Kingdom
ProdList: 6401
Advantage: 74

Apin Chemicals Ltd.

Tel: --
Fax: --
Email: info@apinchemicals.com
Country: United Kingdom
ProdList: 6807
Advantage: 42

VWR International

Tel: --
Fax: --
Email: solutions@vwr.com
Country: United Kingdom
ProdList: 6548
Advantage: 82

More

Less

View Lastest Price from 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone manufacturers

Nanjing Fred Technology Co., Ltd

Product: 5'-Fluoro-2'-hydroxyacetophenone 394-32-1
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1 ton
Release date: 2023-12-20

Hebei Mojin Biotechnology Co.,Ltd

Product: 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 394-32-1
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2024-09-06

Zhengzhou Anbu Chem Co.,Ltd

Product: 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 394-32-1
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000KGS
Release date: 2023-04-24

394-32-1, 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanoneRelated Search:

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 6-Fluoro-4-chromanone 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE 2'-FLUORO-6'-HYDROXYACETOPHENONE 1-(3-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE 4'-Fluoro-2'-hydroxyacetophenone 1-(2-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE 2'-Hydroxyacetophenone 4-Fluorophenol 6-FLUORO-2-METHYL-4-CHROMANONE 6-FLUORO-3-FORMYLCHROMONE 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID METHYL 7-FLUORO-2-(METHOXYMETHYL)-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE 7-FLUORO-2-METHYL-5-OXO-N-[3-(TRIFLUOROMETHYL)PHENYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE (E)-3-(4-CHLOROBENZYLIDENE)-6-FLUORO-2,3-DIHYDROCHROMEN-4-ONE N-(4-CHLOROPHENYL)-7-FLUORO-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID METHYL ESTER

2-Acetyl-4-fluorophenol

1-(5-FLUORO-2-HYDROXY-P

5-Fluoro-2-hydroxyphenyl(methyl) ketone

5'-Fluoro-2'-hydroxyacetophenone,97%

JRH-01009, 1-(5-Fluoro-2-hydroxyphenyl)ethanone, 97%

5’-fluoro-2’-hydroxy-acetophenon

Ethanone, 1-(5-fluoro-2-hydroxyphenyl)-

5'-FLUORO-2'-HYDROXYACETOPHENONE

5-FLUORO-2-HYDROXYACETOPHENONE

2-HYDROXY-5-FLUOROACETOPHENONE

1-(5-FLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE

1-(5-FLUORO-2-HYDROXY-PHENYL)ETHANONE

1-(5-FLUORO-2-HYDROXYPHENYL)-1-ETHANONE

5'-Fluoro-2'-Hydroxyacetophenone 1-(5-Fluoro-2-Hydroxyphenyl)ethan-1-one

2-Hydroxy-5-Fluoroacetophenone99%

5-Fluoro-2-hydroxyacetophenone,98%

5'-Fluoro-2'-hydroxyacetopheno

2-Acety-4-fluorophenol

5'-fluoro-2'-hydroxyacetophenone,1-(5-fluoro-2-hydroxy)ethanone

1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-4-fluorophenol

5'-Fluoro-2'-hydroxyacetophenone&gt

2-hydroxy-5-fluorophenone

5’-Fluoro-2’-hydroxyacetophenone,1-(5-Fluoro-2-hydroxyphenyl)ethanone,5‘-Fluoro-2‘-hydroxyacetophenone,5'-Fluoro-2'-hydroxyacetophenone

TIANFUCHEM 394-32-1 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

1-(5-Fluor-2-hydroxyphenyl)ethan-1-on

1-(5-fluro-2-hydroxyphenyl)ethanone

5'-Fluoro-2'-hydroxyacetophenone

394-32-1

Building Blocks

Carbonyl Compounds

C7 to C8

KETONE

Ketones

Organic Building Blocks

Aryl Fluorinated Building Blocks

Building Blocks

C7 to C8

C7-C8

Chemical Synthesis

Fluorinated Building Blocks

Organic Building Blocks

Organic Fluorinated Building Blocks

Other Fluorinated Organic Building Blocks

Acetophenone series

Adehydes, Acetals & Ketones

Fluorine Compounds

Phenols

C7 to C8

Carbonyl Compounds

Ketones

Aromatic Acetophenones & Derivatives (substituted)

ketone

(intermediate of nebivolol)

Benzenes

Alcohols and Derivatives

Carbonyl Compounds

1