ChemicalBook > CAS DataBase List > 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone

Product Name
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
CAS No.
394-32-1
Chemical Name
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
Synonyms
1-(5-FLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE;5-FLUORO-2-HYDROXYACETOPHENONE;2-Acety-4-fluorophenol;1-(5-FLUORO-2-HYDROXY-P;2-Acetyl-4-fluorophenol;2-hydroxy-5-fluorophenone;2-HYDROXY-5-FLUOROACETOPHENONE;5'-Fluoro-2'-hydroxyacetopheno;5’-fluoro-2’-hydroxy-acetophenon;5'-FLUORO-2'-HYDROXYACETOPHENONE
CBNumber
CB6267638
Molecular Formula
C8H7FO2
Formula Weight
154.14
MOL File
394-32-1.mol
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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Property

Melting point:
56-58 °C(lit.)
Boiling point:
65-66 °C8 mm Hg(lit.)
Density 
1.1850 (estimate)
Flash point:
65-66°C/8mm
storage temp. 
Inert atmosphere,Room Temperature
form 
powder to crystal
pka
10.17±0.18(Predicted)
color 
White to Gray to Brown
Water Solubility 
Soluble 0.68 G/L
BRN 
2359087
CAS DataBase Reference
394-32-1(CAS DataBase Reference)
NIST Chemistry Reference
5-Fluoro-2-hydroxyacetophenone(394-32-1)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-37/39-36/37/39
WGK Germany 
3
RTECS 
AM8502300
HazardClass 
IRRITANT
HS Code 
29147000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
247170
Product name
5′-Fluoro-2′-hydroxyacetophenone
Purity
98%
Packaging
5g
Price
$31.3
Updated
2024/03/01
Sigma-Aldrich
Product number
247170
Product name
5′-Fluoro-2′-hydroxyacetophenone
Packaging
1g
Price
$28.5
Updated
2022/05/15
TCI Chemical
Product number
F0318
Product name
5'-Fluoro-2'-hydroxyacetophenone
Purity
>98.0%(GC)
Packaging
5g
Price
$35
Updated
2024/03/01
TCI Chemical
Product number
F0318
Product name
5'-Fluoro-2'-hydroxyacetophenone
Purity
>98.0%(GC)
Packaging
25g
Price
$89
Updated
2024/03/01
Alfa Aesar
Product number
A15614
Product name
5'-Fluoro-2'-hydroxyacetophenone, 98%
Packaging
5g
Price
$61.7
Updated
2021/12/16
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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Chemical Properties,Usage,Production

Chemical Properties

light yellow to beige-brown crystals 

Uses

5′-Fluoro-2′-hydroxyacetophenone has been used in the preparation of:

  • 1-(5-fluoro-2-hydroxyphenyl)-3-hydroxy-5-phenyl-2,4-pentadien-1-one
  • 3-hydroxy and 3-methoxyflavones
  • 3-hydroxy and 3-methoxy 2-styrylchromones

Definition

ChEBI: 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one is an aromatic ketone.

Preparation

Preparation by Fries rearrangement of 4-fluorophenyl acetate with aluminium chloride without solvent between 115° and 150° (88–89%).

General Description

5-fluoro-2-hydroxy acetophenone, also known as 2-ethanoyl-4-fluorophenol or 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone, is a kind of important medicine intermediate, can be used as multiple beta-blockers synthetic intermediate, has vast market prospect.

Synthesis

The preparation method of 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone under following steps:
Performing double esterification on amino groups and phenolic hydroxy in one step by taking amino-phenol as a raw material.
Performing Fries rearrangement under the condition of aluminum chloride/sodium chloride.
Heating a hydrolyzate after completing fluorine diazotization to obtain finished 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone.

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone Suppliers

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View Lastest Price from 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone manufacturers

Nanjing Fred Technology Co., Ltd
Product
5'-Fluoro-2'-hydroxyacetophenone 394-32-1
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2023-12-20
Hebei Mojin Biotechnology Co.,Ltd
Product
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 394-32-1
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
50000KG/month
Release date
2024-09-06
Zhengzhou Anbu Chem Co.,Ltd
Product
1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 394-32-1
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1000KGS
Release date
2023-04-24

394-32-1, 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanoneRelated Search:

1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone 6-Fluoro-4-chromanone 4'-CHLORO-5-FLUORO-2-HYDROXYBENZOPHENONE 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE 2'-FLUORO-6'-HYDROXYACETOPHENONE 1-(3-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE 4'-Fluoro-2'-hydroxyacetophenone 1-(2-FLUORO-4-HYDROXYPHENYL)-1-ETHANONE 2'-Hydroxyacetophenone 4-Fluorophenol 6-FLUORO-2-METHYL-4-CHROMANONE 6-FLUORO-3-FORMYLCHROMONE 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID METHYL 7-FLUORO-2-(METHOXYMETHYL)-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXYLATE 7-FLUORO-2-METHYL-5-OXO-N-[3-(TRIFLUOROMETHYL)PHENYL]-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE (E)-3-(4-CHLOROBENZYLIDENE)-6-FLUORO-2,3-DIHYDROCHROMEN-4-ONE N-(4-CHLOROPHENYL)-7-FLUORO-2-METHYL-5-OXO-5H-CHROMENO[2,3-B]PYRIDINE-3-CARBOXAMIDE 6-FLUORO-2-METHYL-10-OXO-10H-9-OXA-1-AZA-ANTHRACENE-3-CARBOXYLIC ACID METHYL ESTER

  • 2-Acetyl-4-fluorophenol
  • 1-(5-FLUORO-2-HYDROXY-P
  • 5-Fluoro-2-hydroxyphenyl(methyl) ketone
  • 5'-Fluoro-2'-hydroxyacetophenone,97%
  • JRH-01009, 1-(5-Fluoro-2-hydroxyphenyl)ethanone, 97%
  • 5’-fluoro-2’-hydroxy-acetophenon
  • Ethanone, 1-(5-fluoro-2-hydroxyphenyl)-
  • 5'-FLUORO-2'-HYDROXYACETOPHENONE
  • 5-FLUORO-2-HYDROXYACETOPHENONE
  • 2-HYDROXY-5-FLUOROACETOPHENONE
  • 1-(5-FLUORO-2-HYDROXYPHENYL)ETHAN-1-ONE
  • 1-(5-FLUORO-2-HYDROXY-PHENYL)ETHANONE
  • 1-(5-FLUORO-2-HYDROXYPHENYL)-1-ETHANONE
  • 5'-Fluoro-2'-Hydroxyacetophenone 1-(5-Fluoro-2-Hydroxyphenyl)ethan-1-one
  • 2-Hydroxy-5-Fluoroacetophenone99%
  • 5-Fluoro-2-hydroxyacetophenone,98%
  • 5'-Fluoro-2'-hydroxyacetopheno
  • 2-Acety-4-fluorophenol
  • 5'-fluoro-2'-hydroxyacetophenone,1-(5-fluoro-2-hydroxy)ethanone
  • 1-(5-Fluoro-2-hydroxyphenyl)ethan-1-one, 2-Acetyl-4-fluorophenol
  • 5'-Fluoro-2'-hydroxyacetophenone&gt
  • 2-hydroxy-5-fluorophenone
  • 5’-Fluoro-2’-hydroxyacetophenone,1-(5-Fluoro-2-hydroxyphenyl)ethanone,5‘-Fluoro-2‘-hydroxyacetophenone,5'-Fluoro-2'-hydroxyacetophenone
  • TIANFUCHEM 394-32-1 1-(5-Fluoro-2-hydroxyphenyl)-1-ethanone
  • 1-(5-Fluor-2-hydroxyphenyl)ethan-1-on
  • 1-(5-fluro-2-hydroxyphenyl)ethanone
  • 5'-Fluoro-2'-hydroxyacetophenone
  • 394-32-1
  • Building Blocks
  • Carbonyl Compounds
  • C7 to C8
  • KETONE
  • Ketones
  • Organic Building Blocks
  • Aryl Fluorinated Building Blocks
  • Building Blocks
  • C7 to C8
  • C7-C8
  • Chemical Synthesis
  • Fluorinated Building Blocks
  • Organic Building Blocks
  • Organic Fluorinated Building Blocks
  • Other Fluorinated Organic Building Blocks
  • Acetophenone series
  • Adehydes, Acetals & Ketones
  • Fluorine Compounds
  • Phenols
  • C7 to C8
  • Carbonyl Compounds
  • Ketones
  • Aromatic Acetophenones & Derivatives (substituted)
  • ketone
  • (intermediate of nebivolol)
  • Benzenes
  • Alcohols and Derivatives
  • Carbonyl Compounds
  • 1