2-Amino-4-chloropyrrolo[2,3-d]pyrimidine

Product Name: 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine
CAS No.: 84955-31-7
Chemical Name: 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine
Synonyms: 4-CHLORO-7H-PYRROLO[2,3-D]PYRIMIDIN-2-AMINE;6-CHLORO-7-DEAZAGUANINE;3-d]pyriMidin-2-aMine;2-Amino-4-Chloro-7H-pyrro...;2-amino-6-chloro-7-deazapurine;-Amino-4-chloropyrrolo[2,3-d]pyrimidine;2-Amino-4-chloropyrrolo[2,3-d]pyrimidine;4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-ylam;4-chloro-1H-pyrrolo[2,3-d]pyriMidin-2-aMine;2-Amino-4-Chloro-7H-pyrrolo[2,3-d]pyrimidine
CBNumber: CB6270612
Molecular Formula: C6H5ClN4
Formula Weight: 168.58
MOL File: 84955-31-7.mol

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2-Amino-4-chloropyrrolo[2,3-d]pyrimidine Property

Melting point:: 215-217°C
Boiling point:: 346.6±52.0 °C(Predicted)
Density: 1.82±0.1 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly, Sonicated)
pka: 10.68±0.20(Predicted)
form: Powder
color: Pale yellow to yellow
Stability:: Hygroscopic
InChI: InChI=1S/C6H5ClN4/c7-4-3-1-2-9-5(3)11-6(8)10-4/h1-2H,(H3,8,9,10,11)
InChIKey: VIVLSUIQHWGALQ-UHFFFAOYSA-N
SMILES: C1(N)=NC(Cl)=C2C=CNC2=N1

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Safety

Hazard Codes: Xi
Risk Statements: 36
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: C365170
Product name: 6-Chloro-7-deazaguanine
Packaging: 10g
Price: $85
Updated: 2021/12/16

Usbiological

Product number: C4979
Product name: 6-Chloro-7-deazaguanine
Packaging: 200mg
Price: $403
Updated: 2021/12/16

Matrix Scientific

Product number: 066665
Product name: 4-Chloro-7H-pyrrolo[2,3-d]pyrimidin-2-amine
Packaging: 1g
Price: $25
Updated: 2021/12/16

Apolloscientific

Product number: OR17061
Product name: 2-Amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Purity: 95+%
Packaging: 1g
Price: $34
Updated: 2021/12/16

SynQuest Laboratories

Product number: 3H30-5-Y8
Product name: 2-Amino-4-chloro-7H-pyrrolo[2,3-d]pyrimidine
Purity: 95.0%
Packaging: 1g
Price: $37
Updated: 2021/12/16

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2-Amino-4-chloropyrrolo[2,3-d]pyrimidine Chemical Properties,Usage,Production

Chemical Properties

White Crystalline Solid

Uses

6-Chloro-7-deazaguanine (cas# 84955-31-7) is a compound useful in organic synthesis.

Synthesis

7355-55-7

84955-31-7

2-Amino-4-hydroxypyrrolo[2,3-d]pyrimidine (10.0 g, 66.6 mmol) was added to 100 mL of phosphorus oxychloride (POCl3) and the reaction was carried out at reflux for 2 hours. After completion of the reaction, the solvent was removed by rotary evaporator. After the reaction mixture was cooled to room temperature, it was slowly poured into 120 mL of ice water and the solid product was collected by filtration. The filter cake was washed with ice water and the pH of the filtrate was subsequently adjusted to 2 with ammonia solution and cooled in an ice bath for 2 hours to promote precipitation. The solid product was filtered again and washed sequentially with 10 mL of ice water and 30 mL of ether, resulting in 8.7 g of 2-amino-4-chloropyrrolo[2,3-d]pyrimidine in 78% yield.

References

[1] Liebigs Annalen der Chemie, 1987, p. 15 - 19
[2] Angewandte Chemie - International Edition, 2007, vol. 46, # 13, p. 2325 - 2327
[3] Patent: CN103819523, 2016, B. Location in patent: Paragraph 0048; 0049; 0050
[4] Liebigs Annalen der Chemie, 1983, # 1, p. 137 - 146
[5] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 7, p. 2260 - 2264

2-Amino-4-chloropyrrolo[2,3-d]pyrimidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 84955-31-7
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-28

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 84955-31-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-Amino-4-chloropyrrolo[2,3-d]pyrimidine 84955-31-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

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84955-31-7

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