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BV6

Product Name
BV6
CAS No.
1001600-56-1
Chemical Name
BV6
Synonyms
BV6;CS-1501;CS-2877;BV-6;BV6;BV-6 TFA;BV-6 free;CHEBI:47924;BV6 TFA salt;BV6 USP/EP/BP;CHEBI:47924; BV-6 BV 6
CBNumber
CB62715614
Molecular Formula
C70H96N10O8
Formula Weight
1205.57
MOL File
1001600-56-1.mol
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BV6 Property

Boiling point:
1376.7±65.0 °C(Predicted)
Density 
1.177±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility 
≥60.28 mg/mL in DMSO; insoluble in H2O; ≥12.6 mg/mL in EtOH with ultrasonic
form 
solid
pka
12.89±0.20(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28830
Product name
BV6
Packaging
1mg
Price
$44
Updated
2024/03/01
Cayman Chemical
Product number
28830
Product name
BV6
Packaging
10mg
Price
$321
Updated
2024/03/01
Cayman Chemical
Product number
28830
Product name
BV6
Packaging
5mg
Price
$172
Updated
2024/03/01
TRC
Product number
B810530
Product name
BV-6
Packaging
5mg
Price
$130
Updated
2021/12/16
ApexBio Technology
Product number
B4653
Product name
BV6
Packaging
10mM(in 1mL DMSO)
Price
$290
Updated
2021/12/16
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BV6 Chemical Properties,Usage,Production

Description

BV6 is a bivalent Smac mimetic and an antagonist of the inhibitor of apoptosis (IAP) proteins that binds to IAP1 and XIAP (Kds = 0.46 and 1.3 nM, respectively). It induces autoubiquitination and proteasomal degradation of IAP1 and XIAP in MDA-MB-231 cells when used at a concentration of 5 μM. BV6 (4 μM) induces NF-κB activation and TNF-dependent apoptosis in A2058 and MDA-MB-231 cells. It enhances radiosensitization and increases apoptosis in HCC193 and H460 non-small cell lung cancer (NSCLC) cell lines. BV6 (1 μM) induces cell death in a panel of 40 primary, patient-derived B cell precursor acute lymphoblastic leukemia (BCP-ALL) samples in a TNF-dependent manner. In vivo, BV6 (10 mg/kg) increases survival and the time to relapse in a high-risk BCP-ALL patient-derived xenograft (PDX) mouse model.

Uses

BV-6 is a SMAC mimetic and inhibitor of apoptosis (IAP) inhibitor. Apoptosis agent.

Definition

ChEBI: N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide) is a polyamide consisting of hexane-1,6-diamine having a 1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalanyl moiety attached to both nitrogens. It is functionally related to a methyl 1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninate.

BV6 Preparation Products And Raw materials

Raw materials

Preparation Products

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BV6 Suppliers

China 72 France 1 India 1 United States 15 Global 89
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
Country
United States
ProdList
2782
Advantage
58
Target molecule Corp.
Tel
857-239-0968
Fax
857-239-8801
Email
service1@targetmol.com
Country
United States
ProdList
2559
Advantage
60
Musechem
Tel
+1-800-259-7612
Fax
+1-800-259-7612
Email
info@musechem.com
Country
United States
ProdList
4660
Advantage
60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
BOC Sciences
Tel
16314854226; +16314854226
Email
inquiry@bocsci.com
Country
United States
ProdList
19741
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Cckinase, Inc.
Tel
+1 (732)236-3202
Email
sales@cckinase.com
Country
United States
ProdList
2738
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
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58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
Advantage
58
United States Biological
Tel
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Email
sales@advtechind.com
Country
United States
ProdList
6075
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58
ApexBio Technology
Tel
--
Fax
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Email
sales@apexbt.com
Country
United States
ProdList
6251
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
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65
Cayman Chemical Company
Tel
--
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
United States Biological
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chemicals@usbio.net
Country
United States
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6214
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MedChemExpress
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United States
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6398
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1001600-56-1, BV6Related Search:

LCL-161 MG-132 Birinapant Rapamycin Doxorubicin hydrochloride

  • 4,4'-(1,6-Hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-beta-phenyl-L-phenylalaninamide
  • BV6
  • N,N'-(hexane-1,6-diyl)bis(1-{(2S)-2-cyclohexyl-2-[(N-methyl-L-alanyl)amino]acetyl}-L-prolyl-beta-phenyl-L-phenylalaninamide):trifluoroacetic acid(1:x)
  • CHEBI:47924
  • CHEBI:47924; BV-6 BV 6
  • CS-2877
  • CS-1501
  • BV-6;BV6
  • 4,4'-(1,6-Hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-β-phenyl-L-Phenylalanin
  • BV-6 TFA
  • L-Phenylalaninamide, 4,4'-(1,6-hexanediyl)bis[N-methyl-L-alanyl-(2S)-2-cyclohexylglycyl-L-prolyl-β-phenyl-
  • BV6 USP/EP/BP
  • BV-6 free
  • BV6 TFA salt
  • inhibit,Inhibitor,BV6,IAP,BV-6,BV 6
  • (2S,2'S)-N,N'-((2S,2'S)-(Hexane-1,6-diylbis(azanediyl))bis(1-oxo-3,3-diphenylpropane-1,2-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide)
  • (2S,2'S)-N,N'-((2S,2'S)-(Hexane-1,6-diylbis(azanediyl))bis(1-oxo-3,3-diphenylpropane-1,2-diyl))bis(1-((S)-2-cyclohexyl-2-((S)-2-(methylamino)propanamido)acetyl)pyrrolidine-2-carboxamide)
  • (2S)-2-{[(2S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]pyrrolidin-2-yl]formamido}-N-{6-[(2S)-2-{[(2S)-1-[(2S)-2-cyclohexyl-2-[(2S)-2-(methylamino)propanamido]acetyl]pyrrolidin-2-yl]formamido}-3,3-diphenylpropanamido]hexyl}-3,3-diphenylpropanamide
  • 1001600-56-1
  • C70H96N10O8
  • C70H96N10O8xCF3COOH
  • Inhibitors