Mechanism of Action Indications
ChemicalBook > CAS DataBase List > Clobetasol propionate

Clobetasol propionate

Mechanism of Action Indications
Product Name
Clobetasol propionate
CAS No.
25122-46-7
Chemical Name
Clobetasol propionate
Synonyms
CLOBETASOLE PROPIONATE;Olux;Clobex;Temovate;CLOBETASOL-17-PROPIONATE;Psorex;Olux-E;cgp9555;GR-2/92;Karison
CBNumber
CB6274337
Molecular Formula
C25H32ClFO5
Formula Weight
466.97
MOL File
25122-46-7.mol
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Clobetasol propionate Property

Melting point:
195.5-1970C
alpha 
D +103.8° (c = 1.04 in dioxane)
Boiling point:
569.0±50.0 °C(Predicted)
Density 
1.1653 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,2-8°C
solubility 
Practically insoluble in water, freely soluble in acetone, sparingly soluble in ethanol (96 per cent).
pka
12.88±0.70(Predicted)
form 
Solid
color 
White to off-white
InChI
InChI=1/C25H32ClFO5/c1-5-21(31)32-25(20(30)13-26)14(2)10-18-17-7-6-15-11-16(28)8-9-22(15,3)24(17,27)19(29)12-23(18,25)4/h8-9,11,14,17-19,29H,5-7,10,12-13H2,1-4H3/t14-,17-,18-,19-,22-,23-,24-,25-/s3
InChIKey
CBGUOGMQLZIXBE-XGQKBEPLSA-N
SMILES
O([C@@]1([C@H](C[C@@]2([H])[C@]3([H])CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]12C)C)C(=O)CCl)C(=O)CC |&1:1,2,4,6,16,18,20,23,r|
CAS DataBase Reference
25122-46-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
36/37/38-62-53-48/20/21-61
Safety Statements 
26-36-45-36/37-53
WGK Germany 
2
RTECS 
TU3725000
HS Code 
29372290
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H373May cause damage to organs through prolonged or repeated exposure

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P201Obtain special instructions before use.

P273Avoid release to the environment.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C8037
Product name
Clobetasol propionate
Purity
analytical standard
Packaging
1g
Price
$363
Updated
2024/03/01
Sigma-Aldrich
Product number
1138405
Product name
Clobetasol propionate
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
Cayman Chemical
Product number
21251
Product name
Clobetasol Propionate
Purity
≥98%
Packaging
500mg
Price
$36
Updated
2024/03/01
Cayman Chemical
Product number
21251
Product name
Clobetasol Propionate
Purity
≥98%
Packaging
1g
Price
$63
Updated
2024/03/01
Sigma-Aldrich
Product number
Y0000559
Product name
Clobetasol propionate
Purity
European Pharmacopoeia (EP) Reference Standard
Packaging
y0000559
Price
$220
Updated
2024/03/01
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Clobetasol propionate Chemical Properties,Usage,Production

Mechanism of Action

Clobetasol Propionate is the propionate salt form of clobetasol, a topical synthetic corticosteroid with anti-inflammatory, anti-pruritic, and vasoconstrictive properties. Clobetasol propionate exerts its effect by binding to cytoplasmic glucocorticoid receptors and subsequently activates glucocorticoid receptor mediated gene expression. This results in the synthesis of certain anti-inflammatory proteins, while inhibiting the synthesis of certain inflammatory mediators. Specifically, clobetasol propionate appears to induce phospholipase A2 inhibitory proteins, thereby controlling the release of the inflammatory precursor arachidonic acid from membrane phospholipids by phospholipase A2.

Indications

Clobetasol propionate is the 17-O-propionate ester of clobetasol and it derives from a clobetasol and a propionic acid. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.
Clobetasol propionate was patented in 1968 and came into medical use in 1978. It is available as a generic medication. Clobetasol propionate is used for the treatment of various skin disorders including eczema, herpes labialis, psoriasis, and lichen sclerosus. It is also used to treat several auto-immune diseases, including alopecia areata, lichen planus (auto immune skin nodules), and mycosis fungoides (T-cell skin lymphoma). It is used as first-line treatment for both acute and chronic GVHD of the skin.

Chemical Properties

White or almost white, crystalline powder.

Originator

Dermovate,Glaxo,UK,1973

Uses

Clobetasol-17-propionate is a topical corticosteroid belonging to the group-D (hydrocortisone-q-butyrate) type of steroids.

Uses

For short-term topical treatment of the inflammatory and pruritic manifestations of moderate to severe corticosteroid-responsive dermatoses of the scalp.

Uses

Topical corticosteroid. Glucocorticoid; anti-inflammatory.

Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.

Definition

ChEBI: The 17-O-propionate ester of clobetasol. A potent corticosteroid, it is used to treat various skin disorders, including exzema and psoriasis.

Indications

Clobetasol propionate (Cormax, Temovate, Embeline, Olux) is one of the most potent of the currently available agents and is indicated for short-term treatment of inflammatory or hyperplastic disorders. It is a synthetic fluorinated corticosteroid. It may cause a more rapid or prolonged response than other topical corticosteroids. It is recommended that clobetasol have a maximum application of 60 g/week for no longer than 14 days without occlusion and that it should not be used in children below age 12.

Manufacturing Process

A solution of betamethasone 21-methanesulfonate (4 g) in dimethylformamide (25 ml) was treated with lithium chloride (4 g) and the mixture heated on the steam bath for 30 minutes. Dilution with water gave the crude product which was recrystallized to afford the title compound, MP 226°C.
Clobetasol is usually converted to the propionate as the useful form by reaction with propionic anhydride.

brand name

Clobex (Galderma); Clobex (Galderma); Embeline (Healthpoint); Olux (Connetics); Temovate (Altana).

Therapeutic Function

Corticosteroid, Antiinflammatory

Clobetasol propionate Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Clobetasol propionate manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd
Product
Clobetasol Propionate 25122-46-7
Price
US $150.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
500kg
Release date
2024-11-25
WUHAN FORTUNA CHEMICAL CO., LTD
Product
Clobetasol propionate 25122-46-7
Price
US $0.00-0.00/KG
Min. Order
10g
Purity
97%~102%,USP38
Supply Ability
50kg
Release date
2021-05-28
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.
Product
Clobetasol Propionate 25122-46-7
Price
US $0.00/g
Min. Order
1g
Purity
More Than 99%
Supply Ability
100kg/Month
Release date
2024-09-06

25122-46-7, Clobetasol propionateRelated Search:

Epichlorohydrin Nandrolone phenylpropionate 2-Bromopropionic acid Calcium Propionate 1-chlorotridecane 3-Chloropropyl acetate 6-Chlorohexanol Chloroacetic acid (2-METHYL-1H-INDOL-3-YL)-OXO-ACETIC ACID ETHYL ESTER 1-ACETOXY-3-CHLOROACETONE TRANS-2-FLUOROCYCLOHEXANOL 1-Chlorodecane 1-Chloro-3-ethoxypropane 1-CHLORO-5-METHYLHEXANE 1-Chlorohexadecane 8-Chloro-1-octanol Clobetasol Propionate 25122-46-7 / Base 1-Chlorotetradecane

  • 17-propionate
  • cgp9555
  • Clobetasol 17- propionate solution,100ppm
  • Cloβsol propionate
  • 21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17-propionate
  • CLOBETASOL 17-PROPIONATE USP
  • [(8S,9R,10S,11S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] propanoate
  • Dermovate
  • GR-2/92
  • Olux
  • Psorex
  • Temovate
  • CLOBETASOLPROPIONATE,MICRONIZED
  • CLOBETASOLPROPIONATE,MICRONIZED,USP
  • 21-Chloro-21-deoxybetamethasone 17-propionate
  • CCl 4725
  • Clobederm
  • Dermoval
  • Dermoxinale
  • GR 2/925
  • Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (11β,16β)-
  • Pregna-1,4-diene-3,20-dione, 21-chloro-9-fluoro-11β,17-dihydroxy-16β-methyl-, 17-propionate (8CI)
  • 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione=17-propionate
  • 21-Chloro-9α-fluoro-11β-hydroxy-16β-methyl-17α-propionyloxy-1,4-pregnadiene-3,20-dione
  • Propionic acid clobetasol
  • Clobetasol Propionate (200 mg)
  • 21-Chloro-9-fluoro-11b,17-dihydroxy-16b-methylpregna-1,4-diene-3,20-d
  • propanoic acid [(9R,17R)-17-(2-chloro-1-oxoethyl)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] ester
  • clobesol
  • pregna-1,4-diene-3,20-dione,21-chloro-9-fluoro-11-beta,17-dihydroxy-16-beta-me
  • CLOBESTASOL PROPIONATE
  • CLOBETASOL-17-PROPIONATE
  • CLOBETASOLE PROPIONATE
  • CLOBETASOL PROPIONATE
  • 21-chloro-9-fluoro-11beta,17-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 17-propionate
  • Pregna-1,4-Diene-3,20-Dione,21-Chloro-9-Fluoro-11-Hydroxy-16-Methyl-17-(1-Oxopropoxy)-,(11Beta,16Beta)-
  • Clobetasolpropionatmikron.
  • Karison
  • Olux-E
  • Skin Cap
  • (11β,16β)-21-chloro-9-fluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-pregna-1,4-diene-3,20-dione
  • 21-Chloro-9-fluoro-11b
  • Clobetasol Propionate (200 mg)F2C309980ug/mg(ai)
  • Clobetasol Propionate-d5
  • 21-Chloro-9alpha-fluoro-11beta,17alpha-dihydroxy-16beta-methyl-1,4-pregnadiene-3,20-dione 17-Propionate
  • Clobex
  • Clobetasol Propionate 25122-46-7
  • Skin Disease Corticosteroids Raw Powder Clobetasol Propionate 25122-46-7
  • Clobetasol propionate CRS
  • Clobetasol Propionate RS
  • Cloβsol17-Propionate&gt
  • Clobetasol for peak identification CRS
  • obetasoL
  • 21-Chloro-9-fluoro-11β,17-dihydroxy-16β-Methylpregn-4-ene-3,20-dione 17-Propionate
  • Clobetasol-[d5] 17-propionate
  • Clobetasol propionate USP/EP/BP
  • Clobetazole propionate
  • Clobetasol for peak identification (Y0000570)