2-Fluoro-4-nitroanisole
- Product Name
- 2-Fluoro-4-nitroanisole
- CAS No.
- 455-93-6
- Chemical Name
- 2-Fluoro-4-nitroanisole
- Synonyms
- 2-fluoro-1-methoxy-4-nitrobenzene;2-Fluoro-4-nitroanis;Fluoro-4-nitroanisole;2-FLUORO-4-NITROANISOLE;2-Fluoro-4-nitroanisole>2-Fluoride-4-Nitro Anisole;2-Fluoro-4-nitroanisole98%;2-Fluoro-4-nitroanisole 98%;2-Fluoro-4-nitro-methoxybenzene;2-Methoxy-5-nitro-1-fluorobenzene
- CBNumber
- CB6275006
- Molecular Formula
- C7H6FNO3
- Formula Weight
- 171.13
- MOL File
- 455-93-6.mol
2-Fluoro-4-nitroanisole Property
- Melting point:
- 103-105 °C (lit.)
- Boiling point:
- 277.2±20.0 °C(Predicted)
- Density
- 1.321±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Toluene
- form
- Crystalline Powder
- color
- White to light yellow
- InChIKey
- XGMVTXUXZUPGGY-UHFFFAOYSA-N
- CAS DataBase Reference
- 455-93-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-37/39-36
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HS Code
- 29093090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 334863
- Product name
- 2-Fluoro-4-nitroanisole
- Purity
- 98%
- Packaging
- 5g
- Price
- $51
- Updated
- 2023/01/07
- Product number
- F0617
- Product name
- 2-Fluoro-4-nitroanisole
- Purity
- >98.0%(GC)
- Packaging
- 1g
- Price
- $23
- Updated
- 2025/07/31
- Product number
- F0617
- Product name
- 2-Fluoro-4-nitroanisole
- Purity
- >98.0%(GC)
- Packaging
- 5g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- F593525
- Product name
- 2-Fluoro-4-nitroanisole
- Packaging
- 5g
- Price
- $75
- Updated
- 2021/12/16
- Product number
- F593525
- Product name
- 2-Fluoro-4-nitroanisole
- Packaging
- 1g
- Price
- $55
- Updated
- 2021/12/16
2-Fluoro-4-nitroanisole Chemical Properties,Usage,Production
Chemical Properties
White to light yellow crystalline powder
Uses
2-Fluoro-4-nitroanisole was employed as alternative biochemical photoprobe for proteins.
Synthesis Reference(s)
The Journal of Organic Chemistry, 63, p. 8448, 1998 DOI: 10.1021/jo981557o
General Description
2-Fluoro-4-nitroanisole is a 2-halo-4-nitroanisole and its photoreaction with the nucleophiles hydroxide ion and pyridine has been investigated. Mechanism of photoreaction of 2-fluoro-4-nitroanisole with n-hexylamine has been investigated.
Synthesis
67-56-1
369-34-6
455-93-6
Step 4: Preparation of 3-fluoro-4-methoxyaniline (8) Sodium metal (1.45 g, 63 mmol) was slowly added to methanol (100 mL) pre-cooled to 10 °C under nitrogen protection while stirring. After the sodium metal was completely dissolved, 3,4-difluoronitrobenzene (6) (10 g, 63 mmol) was added to the reaction system and stirred continuously for 2-3 hours at room temperature. Upon completion of the reaction, the mixture was concentrated under vacuum and subsequently poured into ice water (100 mL). The pH of the mixture was adjusted to neutral (~7) by dropwise addition of 2N HCl solution. The precipitated solid was collected by filtration, washed with water, and dried under vacuum to afford the target product 2-fluoro-4-nitroanisole (7) (9.75 g, 91% yield). The melting point of the product was 102-104 °C.
References
[1] Patent: US2006/128729, 2006, A1. Location in patent: Page/Page column 77
[2] Tetrahedron, 2018, vol. 74, # 2, p. 303 - 307
[3] Patent: CN106565522, 2017, A. Location in patent: Paragraph 0037; 0038
[4] Russian Chemical Bulletin, 2006, vol. 55, # 7, p. 1243 - 1247
2-Fluoro-4-nitroanisole Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Fluoro-4-nitroanisole manufacturers
- Product
- 2-Fluoro-4-nitroanisole 455-93-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 10mg
- Purity
- 99%
- Supply Ability
- 2000tons
- Release date
- 2020-01-16
- Product
- 2-Fluoro-4-nitroanisole 455-93-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10
- Product
- 2-Fluoro-4-nitroanisole 455-93-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09