Spermine

Product Name: Spermine
CAS No.: 71-44-3
Chemical Name: Spermine
Synonyms: SPERMINE TETRAHYDROCHLORIDE;Spermin;NEURIDINE HYDROCHLORIDE;MUSCULAMINE HYDROCHLORIDE;DJtPAT;Spermine;NSC 268508;Spermine,97%;Spermine >98%;SOYASAPONIN IV(SH)
CBNumber: CB6275334
Molecular Formula: C10H26N4
Formula Weight: 202.34
MOL File: 71-44-3.mol

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Spermine Property

Melting point:: 28-30 (lit.)
Boiling point:: 150 °C/5 mmHg (lit.)
Density: 0.937
refractive index: 1.4850 (estimate)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: H₂O: 1 M at 20 °C, clear, colorless
form: powder
pka: 10.88±0.19(Predicted)
color: Colorless to off-white
Water Solubility: Soluble in chloroform, methanol, water and lower alcohols. Insoluble in ether, benzene and petroleum ether.
Sensitive: Air Sensitive & Hygroscopic
Merck: 14,8743
BRN: 1751791
Stability:: Hygroscopic
InChIKey: PFNFFQXMRSDOHW-UHFFFAOYSA-N
LogP: -0.543 (est)
CAS DataBase Reference: 71-44-3(CAS DataBase Reference)
NIST Chemistry Reference: Spermine(71-44-3)
EPA Substance Registry System: 1,4-Butanediamine, N,N'-bis(3-aminopropyl)- (71-44-3)

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Safety

Hazard Codes: Xi,C
Risk Statements: 36/38-34
Safety Statements: 26-36-45-36/37/39-27
RIDADR: UN 3259 8/PG 2
WGK Germany: 3
RTECS: EJ7230000
F: 3-10
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29212900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 85590
Product name: Spermine
Purity: ≥99.0% (GC)
Packaging: 5g
Price: $321
Updated: 2024/03/01

Sigma-Aldrich

Product number: 55513
Product name: Spermine
Purity: analytical standard
Packaging: 100mg
Price: $73.6
Updated: 2024/03/01

Alfa Aesar

Product number: L19562
Product name: Spermine, 97%
Packaging: 1g
Price: $58.9
Updated: 2024/03/01

Alfa Aesar

Product number: L19562
Product name: Spermine, 97%
Packaging: 5g
Price: $188
Updated: 2024/03/01

Cayman Chemical

Product number: 18041
Product name: Spermine
Purity: ≥95%
Packaging: 1g
Price: $37
Updated: 2024/03/01

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Spermine Chemical Properties,Usage,Production

Description

Spermine is an endogenous polyamine synthesized from the reaction of spermidine with decarboxylated S-adenosylmethionine in the presence of the enzyme spermine synthase and is required for eukaryotic cell growth and protein synthesis. Intracellular spermine blocks inward rectifying K⁺ channels, whereas extracellular spermine acts as a mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Spermine has neuroprotective and anti-inflammatory effects and functions as a free radical scavenger to prevent DNA damage by reactive oxygen species.

Chemical Properties

White to slightly off-white powder crysta

Uses

immune modulator

Uses

Binds to the polyamine modulatory site of NMDA Spermine is essential for both normal and neoplastic tissue growth. It is involved in the modulation of calcium-dependent immune processes. It plays an important role in cellular proliferation and differentiation as well as inhibits neuronal nitric oxide synthase (nNOS).

Uses

Biogenic polyamine formed from spermidine and occurring in almost all tissues. Essential for both normal and neoplastic tissue growth. Involved in the modulation of calcium-dependent immune processes

Definition

ChEBI: A polyazaalkane that is tetradecane in which the carbons at positions 1, 5, 10 and 14 are replaced by nitrogens. Spermine has broad actions on cellular metabolism.

General Description

Spermine?is a polyamine, which functions as a free radical scavenger. It modulates gene expression, chromatin stabilization and prevents DNA damage. Spermine inhibits endonuclease-mediated DNA fragmentation.

Biochem/physiol Actions

Mixed NMDA glutamate receptor agonist/antagonist at the polyamine site. Neuroprotective effects have been observed at high concentrations (1 mM), while neurotoxicity is observed at lower concentrations. It enhances agonist effectiveness at the strychnine-insensitive glycine site. Plays a role in cellular proliferation and differentiation; inhibits neuronal nitric oxide synthase (nNOS).

storage

+4°C (desiccate)

References

[1] fakler b, brndle u, glowatzki e, et al. strong voltage-dependent inward rectification of inward rectifier k+ channels is caused by intracellular spermine[j]. cell, 1995, 80(1): 149-154.
[2] til h p, falke h e, prinsen m k, et al. acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats[j]. food and chemical toxicology, 1997, 35(3): 337-348.

Spermine Preparation Products And Raw materials

Raw materials

Coconut oil

Preparation Products

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Spermine Suppliers

Belgium 1 Canada 1 China 268 France 1 Germany 3 India 5 Japan 1 Slovakia 1 Switzerland 4 United Kingdom 10 United States 36 USA 1 Global 332

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View Lastest Price from Spermine manufacturers

Hangzhou Hyper Chemicals Limited

Product: Spermine 71-44-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 5,000KG
Release date: 2024-08-07

Hebei Weibang Biotechnology Co., Ltd

Product: Spermine 71-44-3
Price: US $0.00-0.00/KG
Min. Order: 50KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2022-09-27

Hangzhou Zelixir Biotech Co., Ltd.

Product: Spermine 71-44-3
Price: US $0.00-0.00/kg
Min. Order: 0.1kg
Purity: 99.5%
Supply Ability: 1000
Release date: 2023-12-29

71-44-3, SpermineRelated Search:

Histamine Ethanethiol Diallylamine POLYAMINOPROPYL BIGUANIDE N,N-Diisopropylethylamine Diisopropylamine 1,4-DIAMINOBUTANE Spermidine Triallylamine Succinic acid Allylamine L(+)-Arginine O,O-Dimethyl phosphoramidothioate SPERMINE TETRAHYDROCHLORIDE SPERMINE TETRAHYDROCHLORIDE, [TERMINAL METHYLENE-3H] Spermine [14C]SPERMINE TETRAHYDROCHLORIDE

SPERMINE TETRAHYDROCHLORIDE

SPERMINE HYDROCHLORIDE

n,n’-bis(3-aminopropyl)-4-butanediamine

n,n’-bis(3-aminopropyl)-4-diaminobutane

Spermin

N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE 4 H CL

N,N'-BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TETRAHYDROCHLORIDE

N,N'-BIS-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE TETRAHYDROCHLORIDE

N,N'-BIS(3-AMINOPROPYL)-BUTANE-1,4-DIAMINE TETRAHYDROCHLORIDE

NEURIDINE HYDROCHLORIDE

NEURIDINE TETRAHYDROCHLORIDE

MUSCULAMINE HYDROCHLORIDE

MUSCULAMINE TETRAHYDROCHLORIDE

Spermine

SOYASAPONIN IV(SH)

Spermine,N,N′-Bis(3-aminopropyl)-1,4-diaminobutane, Gerontine, Musculamine, Neuridine

Spermine >98%

N,N'-Bis(3-aminopropyl)-1,4-butanediamine

N1,N1'-(butane-1,4-diyl)bis(propane-1,3-diaMine)

GERONTINE TETRAHYDROCHLORIDE

DIAMINOPROPYLTETRAMETHYLENEDIAMINE HYDROCHLORIDE

1,4-BIS(AMINOPROPYL)BUTANEDIAMINE TETRAHYDROCHLORIDE

4,9-diazadodecamethylenediamine

N,N-Bis(3-aminopropyl)-1,4-diaminobutane~Gerontine~Musculamine~Neuridine

Spermine N,N-Bis(3-aminopropyl)-1,4-diaminobutane

SPERMINE FREE BASE CELL CULTURE TESTED

Spermine,97%

Sperminedihydrate,97%

BIS(3-AMINOPROPYL)-1,4-BUTANEDIAMINE

NSC 268508

SPERMINE FREE BASE extrapure

1,4-Bis(aminopropyl)butanediamine

1,4-Butanediamine, N,N'-bis(3-aminopropyl)-

1,4-Diaminobutane, N,N'-bis(3-aminopropyl)-

4,9-Diaza-1,12-dodecanediamine

4,9-Diazadodecane-1,12-diamine

N,NBis(2-aminopropyl)-1,4-butane-diamine, N,NBis(2-aminopropyl)tetramethylenediamine

SPERMINE >= 99.0% (GC)

bis(propane-1,3-diamine)

N1,N1'-(Butane-1,4-diyl)

1,4-Butanediamine, N1,N4-bis(3-aminopropyl)-

DJtPAT

Spermine CAS 71-44-3 with Best Price Fast Delivery Good Quality

Spermine (NSC-268508

(3-aminopropyl)({4-[(3-aminopropyl)amino]butyl}) amine

Spermine, ≥99% (GC)

N,N'-bis(3-aminopropyl)butane-1,4-diamine

N1,N1'-(Butane-1,4-diyl)bis(propane-1,3-diamine)

Gerontine|||Musculamine|||4,9-Diaza-1,12-dodecanediamine|||NSC 268508|||Neuridine

Spermine in methanol

71-44-3

77-44-3

H2NCH23NHCH23NH2

NH2CH23NHCH24NHCH23NH2

H2NCNHNHCH24NH2

C10H26N4

Amino Acids and Peptides

Biochemicals and Reagents