1,1-Cyclopropanedicarboxylic acid monomethyl ester
- Product Name
- 1,1-Cyclopropanedicarboxylic acid monomethyl ester
- CAS No.
- 113020-21-6
- Chemical Name
- 1,1-Cyclopropanedicarboxylic acid monomethyl ester
- Synonyms
- 1-(Methoxycarbonyl)cyclopropane-1-carboxylic acid;1-(methoxycarbonyl)cyclopropanecarboxylic acid;Oliceridine Impurity 23;Cyclopropane-1,1-dicarboxylicacid,Methy;Cyclopropyl -1, 1-diformate mono-tyrosol;113020-21-6;1,1-Cyclopropanedicarboxylic acid-1-methyl e;Monomethyl 1,1-cyclopropyl dicarboxylic acid;CYCLOPROPANE-1,1-DICARBOXYLIC ACID, METHYL ESTER;1,1-CYCLOPROPANEDICARBOXYLIC ACID-1-METHYL ESTER
- CBNumber
- CB6275637
- Molecular Formula
- C6H8O4
- Formula Weight
- 144.13
- MOL File
- 113020-21-6.mol
1,1-Cyclopropanedicarboxylic acid monomethyl ester Property
- Melting point:
- 47-51°C
- Boiling point:
- 85-87°C/0.2mm
- Density
- 1.419
- Flash point:
- 104 °C
- storage temp.
- Sealed in dry,Room Temperature
- form
- crystalline solid
- pka
- 3.37±0.20(Predicted)
- color
- White
- Water Solubility
- Slightly soluble in water.
- InChI
- InChI=1S/C6H8O4/c1-10-5(9)6(2-3-6)4(7)8/h2-3H2,1H3,(H,7,8)
- InChIKey
- IZYOHLOUZVEIOS-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)(C(OC)=O)CC1
Safety
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B485993
- Product name
- 1-(methoxycarbonyl)cyclopropane-1-carboxylicacid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B485993
- Product name
- 1-(methoxycarbonyl)cyclopropane-1-carboxylicacid
- Packaging
- 250mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- B485993
- Product name
- 1-(methoxycarbonyl)cyclopropane-1-carboxylicacid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- Y7088
- Product name
- Cyclopropane-1,1-dicarboxylicacid,methylester
- Packaging
- 1g
- Price
- $21
- Updated
- 2021/12/16
- Product number
- 016120
- Product name
- Cyclopropane-1,1-dicarboxylic acid mono methyl ester
- Purity
- 97%
- Packaging
- 1g
- Price
- $23
- Updated
- 2021/12/16
1,1-Cyclopropanedicarboxylic acid monomethyl ester Chemical Properties,Usage,Production
Uses
1,1-Cyclopropanedicarboxylic acid monomethyl ester is used as a pharmaceutical intermediate.
Synthesis
6914-71-2
113020-21-6
1. KOH (42 mg, 0.75 mmol) was added to a methanolic solution of dimethyl cyclopropane-1,1-dicarboxylate (100 mg, 0.63 mmol). 2. The reaction mixture was stirred at room temperature for 4 hours. 3. After completion of the reaction, the solvent was removed by concentration under reduced pressure. 4. The residue was diluted with water and acidified with concentrated hydrochloric acid to pH<2. 5. The acidified aqueous phase was extracted with dichloromethane (3 x 10 mL). 6. The organic phases are combined and dried over anhydrous sodium sulfate. 7. The desiccant was removed by filtration and the filtrate was concentrated under reduced pressure to give cyclopropane-1,1-dicarboxylic acid monomethyl ester (65 mg, 71% yield) as a white solid.
References
[1] Bioorganic and Medicinal Chemistry Letters, 2008, vol. 18, # 6, p. 2188 - 2193
[2] Patent: US2009/239848, 2009, A1. Location in patent: Page/Page column 33
[3] Patent: WO2012/74761, 2012, A1. Location in patent: Page/Page column 20-21
[4] Organic Letters, 2011, vol. 13, # 16, p. 4180 - 4183
[5] Patent: EP1577301, 2005, A1. Location in patent: Page/Page column 148
1,1-Cyclopropanedicarboxylic acid monomethyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
1,1-Cyclopropanedicarboxylic acid monomethyl ester Suppliers
- Tel
- 18001856580
- Fax
- QQ：2415195517
- 2415195517@qq.com
- Country
- China
- ProdList
- 44
- Advantage
- 58
- Tel
- 02583221260;025-83221260
- renqing401@163.com
- Country
- China
- ProdList
- 274
- Advantage
- 55
- Tel
- 022-60189726 18812034280
- Fax
- 86-22-60979672
- 188120342808@163.com
- Country
- China
- ProdList
- 143
- Advantage
- 61
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44802
- Advantage
- 61
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 11777
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9309
- Advantage
- 66
- Tel
- 21-57721279 18121011378
- Fax
- QQ：14057904
- sales@shydchem.com.cn
- Country
- China
- ProdList
- 998
- Advantage
- 56
View Lastest Price from 1,1-Cyclopropanedicarboxylic acid monomethyl ester manufacturers
- Product
- 1,1-Cyclopropanedicarboxylic acid monomethyl ester 113020-21-6
- Price
- US $8.00-2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-24
- Product
- 1,1-Cyclopropanedicarboxylic acid monomethyl ester 113020-21-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 95%-99%
- Supply Ability
- 1000kg
- Release date
- 2019-08-26