ChemicalBook > CAS DataBase List > SUC-LEU-LEU-VAL-TYR-AMC

SUC-LEU-LEU-VAL-TYR-AMC

Product Name
SUC-LEU-LEU-VAL-TYR-AMC
CAS No.
94367-21-2
Chemical Name
SUC-LEU-LEU-VAL-TYR-AMC
Synonyms
Z-LLVY-AMC;SUC-LLVY-AMC;Felypressin Impurity 8;SUC-LEU-LEU-VAL-TYR-MCA;SUC-LEU-LEU-VAL-TYR-AMC;Suc-Leu-Leu-Val-Tyr-AMC(TFA);CALPAIN SUBSTRATE (FLUOROGENIC);SUC-LEU-LEU-VAL-TYR-AMC USP/EP/BP;PROTEASOME SUBSTRATE III (FLUOROGENIC);CHYMOTRYPSIN SUBSTRATE III, FLUOROGENIC
CBNumber
CB6290865
Molecular Formula
C40H53N5O10
Formula Weight
763.88
MOL File
94367-21-2.mol
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SUC-LEU-LEU-VAL-TYR-AMC Property

Boiling point:
1116.8±65.0 °C(Predicted)
Density 
1.249±0.06 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in DMSO (up to 20 mg/ml), or in DMF (up to 10 mg/ml)
pka
4.69±0.10(Predicted)
form 
Lyophilized solid
color 
White to Off-White
Sequence
Suc-Leu-Leu-Val-Tyr-AMC
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
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Safety

WGK Germany 
3
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
S6510
Product name
N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin
Purity
≥90% (HPLC)
Packaging
1mg
Price
$65.7
Updated
2024/03/01
Sigma-Aldrich
Product number
S6510
Product name
N-Succinyl-Leu-Leu-Val-Tyr-7-Amido-4-Methylcoumarin
Purity
≥90% (HPLC)
Packaging
5mg
Price
$187
Updated
2024/03/01
Alfa Aesar
Product number
J66784
Product name
Chymotrypsin Substrate III, fluorogenic
Packaging
1mg
Price
$58.9
Updated
2023/06/20
Cayman Chemical
Product number
10008119
Product name
Suc-Leu-Leu-Val-Tyr-AMC
Purity
≥98%
Packaging
1mg
Price
$34
Updated
2024/03/01
Cayman Chemical
Product number
10008119
Product name
Suc-Leu-Leu-Val-Tyr-AMC
Purity
≥98%
Packaging
5mg
Price
$85
Updated
2024/03/01
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SUC-LEU-LEU-VAL-TYR-AMC Chemical Properties,Usage,Production

Description

Suc-Leu-Leu-Val-Tyr-AMC (94367-21-2) is a fluorogenic substrate for the chymotryptic activity of the 20S proteasome1 and other chymotrypsin-like proteases, as well as calpains2. A commonly used substrate for assaying proteasomal enzymatic activity.3,4 Excitation max.: 360 nm; emission max.: 460 nm.

Uses

Suc-Leu-Leu-Val-Tyr-AMC is a fluorgenic substrate for chymotrypsin-like proteases, as well as calpains. It can be used to treat tuberculosis.

Definition

ChEBI: A tetrapeptide compound with a succinyl group at the N-terminal and a 7-amino-4-methylcoumarin group at the C-terminal.

Biochem/physiol Actions

In the presence of chymotrypsin-like enzyme activity, the fluorophore, 7-amido-4-methylcoumarin is released from N-succinyl-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin. The fluorescence obtained is a measure of the enzyme activity.6

References

1) Stein et al. (1996), Kinetic characterization of the chymotryptic activity of the 20S proteasome; Biochemistry, 35 3899 2) Sasaki et al. (1984), Comparative specificity and kinetic studies on porcine calpain I and calpain II with naturally occurring peptides and synthetic fluorogenic substrates; J. Biol. Chem., 259 12489 3) Hamouda et al. (2014), The small heat shock protein B8 (HSPB8) confers resistance to bortezomib by promoting autophagic removal of misfolded proteins in multiple myeloma cells; Oncotarget, 5 6252 4) Min et al. (2017), USP14 inhibitor attenuates cerebral ischemia/reperfusion-induced neuronal injury in mice; J. Neurochem,, 140 826

SUC-LEU-LEU-VAL-TYR-AMC Preparation Products And Raw materials

Raw materials

Preparation Products

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SUC-LEU-LEU-VAL-TYR-AMC Suppliers

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94367-21-2, SUC-LEU-LEU-VAL-TYR-AMCRelated Search:

SUC-ALA-PRO-PNA CHYMOTRYPSIN SUBSTRATE I, COLORIMETRIC SUC-GLY-PHE-GLY-PNA SUC-PHE-LEU-PHE-PNA SUC-ARG-PRO-TYR-PNA Nafamostat mesylate CL 82198 HYDROCHLORIDE BESTATIN HYDROCHLORIDE COELENTERAZINE H SUC-PHE-PRO-PHE-PNA SUC-ALA-VAL-PRO-PHE-PNA SUC-PHE-ALA-ALA-PHE-PNA SUC-GLY-PRO-LEU-GLY-PRO-AMC SUC-TYR-VAL-ALA-ASP-AMC SUC-GLY-PRO-AMC SUC-LEU-LEU-VAL-TYR-PNA SUC-GLY-PRO-PNA SUC-ARG-PRO-PHE-HIS-LEU-LEU-VAL-TYR-AMC TFA

  • Z-LLVY-AMC
  • succinyl-leucyl-leucyl-valyl-tyrosyl-methylcoumarinamide
  • SUC-LLVY-AMC
  • SUC-LEU-LEU-VAL-TYR-AMC
  • SUC-LEU-LEU-VAL-TYR-MCA
  • SUC-LEU-LEU-VAL-TYR-7-AMINO-4-METHYLCOUMARIN
  • SUCCINYL-L-LEUCYL-L-LEUCYL-L-VALYL-L-TYROSINE-4-METHYLCOUMARINYL-7-AMIDE
  • SUCCINYL-L-LEUCYL-L-LEUCYL-L-VALYL-L-TYROSINE 4-METHYLCOUMARYL-7-AMIDE
  • PROTEASOME 20S, (SUC-LEU-LEU-VAL-TYR-AMC)
  • PROTEASOME SUBSTRATE III (FLUOROGENIC)
  • N-SUCCINYL-LEU-LEU-VAL-TYR 7-AMIDO-4-METHYLCOUMARIN
  • N-SUCCINYL-LEU-LEU-VAL-TYR-7-AMINO-4-METHYLCOUMARIN AMC
  • N-SUCCINYL-L-LEUCYL-L-LEUCYL-L-VALYL-L-TYROSINE-4-METHYLCOUMARYL-7-AMIDE
  • N-SUCCINYL-LEU-LEU-VAL-TYR 7-AMIDO-4-*ME THYLCOUMARI
  • N-Succinyl-l-leucyl-l-leucyl-l-valyl-l-tyrosine-4-methylcoumaryl-7-amidefluorogenicsubstrateforchymotryspin
  • CALPAIN SUBSTRATE (FLUOROGENIC)
  • CHYMOTRYPSIN SUBSTRATE III, FLUOROGENIC
  • 4-[[1-[[1-[[(1S)-1-[[(1S)-1-(4-hydroxybenzyl)-2-keto-2-[(2-keto-4-methyl-chromen-7-yl)amino]ethyl]carbamoyl]-2-methyl-propyl]carbamoyl]-3-methyl-butyl]carbamoyl]-3-methyl-butyl]amino]-4-keto-butyric acid
  • 4-[[1-[[1-[[(2S)-1-[[(2S)-3-(4-hydroxyphenyl)-1-[(4-methyl-2-oxo-chromen-7-yl)amino]-1-oxo-propan-2-yl]amino]-3-methyl-1-oxo-butan-2-yl]amino]-4-methyl-1-oxo-pentan-2-yl]amino]-4-methyl-1-oxo-pentan-2-yl]amino]-4-oxo-butanoic acid
  • 4-[[1-[[1-[[(2S)-1-[[(2S)-3-(4-hydroxyphenyl)-1-[(4-methyl-2-oxochromen-7-yl)amino]-1-oxopropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-methyl-1-oxopentan-2-yl]amino]-4-oxobutanoic acid
  • CHYMOTRYPSIN SUBSTRATE III, FLUOROGENIC ; SUC-LEU-LEU-VAL-TYR-AMC
  • succinyl-Leu-Leu-Val-Tyr-7-amino-4-methylcoumarin
  • L-Tyrosinamide, N-(3-carboxy-1-oxopropyl)-L-leucyl-L-leucyl-L-valyl-N-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)-
  • SUC-LEU-LEU-VAL-TYR-AMC USP/EP/BP
  • Felypressin Impurity 8
  • Suc-Leu-Leu-Val-Tyr-AMC(TFA)
  • 94367-21-2
  • C40H53N5O10
  • BioChemical
  • Biochemicals and Reagents
  • Cell Signaling Enzymes
  • Application Index
  • Apoptosis Products
  • Calpain
  • Enzymes, Inhibitors, and Substrates
  • Fluorimetric Substrates
  • Pepetides