EUK 134
- Product Name
- EUK 134
- CAS No.
- 81065-76-1
- Chemical Name
- EUK 134
- Synonyms
- EUK 134;ETHYLBISIMINOMETHYLGUAIACOL MANGANESE CHLORIDE;SALEN-MN;Salen-Mn-Cl;SALEN-MN/EUK-134;SALEN-MN USP/EP/BP;EUK 134, SOD/catalase mimetic;Manganese (salen-3,3'-diMethoxy) chloride;Ethylbis aminomethyl Guaiacol manganese chloride;ethylbisiminomethylguaiacol manganese chloride (EUK134)
- CBNumber
- CB6291079
- Molecular Formula
- C18H18ClMnN2O4
- Formula Weight
- 416.74
- MOL File
- 81065-76-1.mol
EUK 134 Property
- storage temp.
- -20°C
- solubility
- H2O: soluble2mg/mL, clear (warmed)
- form
- powder
- color
- faint to very dark brown
- InChI
- InChI=1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+3/p-3/b19-11+,20-12+;;
- InChIKey
- YUZJJFWCXJDFOQ-GAMUHHASSA-K
- SMILES
- [Cl-][Mn+3]123[O-]C4C(=CC=CC=4C=N1CCN2=CC1=CC=CC(OC)=C1[O-]3)OC
Safety
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- SML0743
- Product name
- EUK-134
- Purity
- ≥95% (HPLC)
- Packaging
- 10mg
- Price
- $44.46
- Updated
- 2024/03/01
- Product number
- SML0743
- Product name
- EUK-134
- Purity
- ≥95% (HPLC)
- Packaging
- 50mg
- Price
- $303
- Updated
- 2024/03/01
- Product number
- 10006329
- Product name
- EUK 134
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $38
- Updated
- 2024/03/01
- Product number
- 10006329
- Product name
- EUK 134
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $64
- Updated
- 2024/03/01
- Product number
- 10006329
- Product name
- EUK 134
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $238
- Updated
- 2024/03/01
EUK 134 Chemical Properties,Usage,Production
Uses
EUK-134 has been used as an antioxidant.
benefits
EUK-134 has been used as an antioxidant. An antioxidant serum that protects the skin from pollution and other external aggressors. In addition, it helps to reduce the appearance of redness and UV damage such as pigmentation and dark spots.
Biological Activity
euk 134, a synthetic superoxide dismutase (sod)/catalase mimetic, has exhibited potent antioxidant activities and inhibited the formation of β-amyloid and related amyloid fibril.
Biochem/physiol Actions
EUK-134 is a manganese-salen derivative that exhibit potent antioxidant activities. EUK-134 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-134 disrupts the pre-formed amyloid fibrils. EUK-134 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.
in vitro
euk-134, a salen-manganese complex, showed potent catalase and cytoprotective activities and sod activity. after middle cerebral artery occlusion, euk-134 administration at 3 hr significantly reduced brain infarct size, with the highest dose apparently preventing further infarct growth[1]. administration of euk 134 (20 μm) prevented aβ-induced microglial proliferation in vitro[2]. in human neuroblastoma cell line sk-n-mc, pre-treatments with euk134 protected cells against h2o2-induced oxidative stress through inhibition of mapk pathway in a dose-dependent manner.euk134 also decreased the expression of pro-apoptotic genes p53 and bax and enhanced expression of anti-apoptotic bcl-2 gene [3]. incubation of human amylin with euk-134 significantly inhibited amyloid formation at two molar ratios of 1:1 and 5:1 (drugs to protein)[4].
in vivo
compared to the vehicle-injected rats, the euk-134-treated group at doses of 0.5 and 5.0 μmol/kg (0.25 and 2.5 mg/kg, respectively) exhibited infarct volumes that were significantly lower than those of vehicle-injected rats. at 5.0 μmol/kg, euk-134 reduced the infarct volume by 90% when compared with that of the vehicle controls [1].euk-134 protected most of the vulnerable neurons from excitotoxic cell death.euk-134 significantly reduced (p< 0.05) ka-induced neuronal damage in ca1 (22% of total neurons), an almost complete protection in ca3 (7%) and piriform cortex (14%), indicating that euk-134 prevented most but not all neuronal damage resulting from ka-induced seizure activity [5].
References
[1]. baker k, marcus c b, huffman k, et al. synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury[j]. journal of pharmacology and experimental therapeutics, 1998, 284(1): 215-221.
[2]. jekabsone a, mander p k, tickler a, et al. fibrillar beta-amyloid peptide aβ 1–40 activates microglial proliferation via stimulating tnf-α release and h 2 o 2 derived from nadph oxidase: a cell culture study[j]. journal of neuroinflammation, 2006, 3(1): 1.
[3]. mohammadi m, yazdanparast r. modulation of h2o2‐induced mitogen‐activated protein kinases activation and cell death in sk‐n‐mc cells by euk134, a salenderivative[j]. basic & clinical pharmacology & toxicology, 2011, 108(6): 378-384.
[4]. bahramikia s, yazdanparast r. inhibition of human islet amyloid polypeptide or amylin aggregation by two manganese-salenderivatives[j]. european journal of pharmacology, 2013, 707(1): 17-25.
[5]. rong y, doctrow s r, tocco g, et al. euk-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology[j]. proceedings of the national academy of sciences, 1999, 96(17): 9897-9902.
EUK 134 Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from EUK 134 manufacturers
- Product
- EUK-134 81065-76-1
- Price
- US $30.00-0.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-04-26
- Product
- SALEN-MN(EUK 134) 81065-76-1
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.10000000149011612kg
- Purity
- 98%
- Supply Ability
- 2000kgs
- Release date
- 2024-04-18
- Product
- EUK 134 81065-76-1
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500KGS
- Release date
- 2024-03-26