EUK 134

ChemicalBook > CAS DataBase List > EUK 134

Product Name: EUK 134
CAS No.: 81065-76-1
Chemical Name: EUK 134
Synonyms: EUK 134;ETHYLBISIMINOMETHYLGUAIACOL MANGANESE CHLORIDE;SALEN-MN;Salen-Mn-Cl;SALEN-MN/EUK-134;SALEN-MN USP/EP/BP;EUK 134, SOD/catalase mimetic;Manganese (salen-3,3'-diMethoxy) chloride;Ethylbis aminomethyl Guaiacol manganese chloride;ethylbisiminomethylguaiacol manganese chloride (EUK134)
CBNumber: CB6291079
Molecular Formula: C18H18ClMnN2O4
Formula Weight: 416.74
MOL File: 81065-76-1.mol

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EUK 134 Property

storage temp.: -20°C
solubility: H2O: soluble2mg/mL, clear (warmed)
form: powder
color: faint to very dark brown
InChI: InChI=1S/C18H20N2O4.ClH.Mn/c1-23-15-7-3-5-13(17(15)21)11-19-9-10-20-12-14-6-4-8-16(24-2)18(14)22;;/h3-8,11-12,21-22H,9-10H2,1-2H3;1H;/q;;+3/p-3/b19-11+,20-12+;;
InChIKey: YUZJJFWCXJDFOQ-GAMUHHASSA-K
SMILES: [Cl-][Mn+3]123[O-]C4C(=CC=CC=4C=N1CCN2=CC1=CC=CC(OC)=C1[O-]3)OC

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0743
Product name: EUK-134
Purity: ≥95% (HPLC)
Packaging: 10mg
Price: $44.46
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0743
Product name: EUK-134
Purity: ≥95% (HPLC)
Packaging: 50mg
Price: $303
Updated: 2024/03/01

Cayman Chemical

Product number: 10006329
Product name: EUK 134
Purity: ≥98%
Packaging: 5mg
Price: $38
Updated: 2024/03/01

Cayman Chemical

Product number: 10006329
Product name: EUK 134
Purity: ≥98%
Packaging: 10mg
Price: $64
Updated: 2024/03/01

Cayman Chemical

Product number: 10006329
Product name: EUK 134
Purity: ≥98%
Packaging: 50mg
Price: $238
Updated: 2024/03/01

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EUK 134 Chemical Properties,Usage,Production

Uses

EUK-134 has been used as an antioxidant.

benefits

EUK-134 has been used as an antioxidant. An antioxidant serum that protects the skin from pollution and other external aggressors. In addition, it helps to reduce the appearance of redness and UV damage such as pigmentation and dark spots.

Biological Activity

euk 134, a synthetic superoxide dismutase (sod)/catalase mimetic, has exhibited potent antioxidant activities and inhibited the formation of β-amyloid and related amyloid fibril.

Biochem/physiol Actions

EUK-134 is a manganese-salen derivative that exhibit potent antioxidant activities. EUK-134 is a superoxide dismutase (SOD) that inhibits amyloid fibril formation, including islet amyloid polypeptide (IAPP), β-amyloid and lysozyme amyloid aggregation. It appears that EUK-134 disrupts the pre-formed amyloid fibrils. EUK-134 increases the viability of the SK-N-MC cells exposed to preformed IAPP fibrils.

in vitro

euk-134, a salen-manganese complex, showed potent catalase and cytoprotective activities and sod activity. after middle cerebral artery occlusion, euk-134 administration at 3 hr significantly reduced brain infarct size, with the highest dose apparently preventing further infarct growth[1]. administration of euk 134 (20 μm) prevented aβ-induced microglial proliferation in vitro[2]. in human neuroblastoma cell line sk-n-mc, pre-treatments with euk134 protected cells against h2o2-induced oxidative stress through inhibition of mapk pathway in a dose-dependent manner.euk134 also decreased the expression of pro-apoptotic genes p53 and bax and enhanced expression of anti-apoptotic bcl-2 gene [3]. incubation of human amylin with euk-134 significantly inhibited amyloid formation at two molar ratios of 1:1 and 5:1 (drugs to protein)[4].

in vivo

compared to the vehicle-injected rats, the euk-134-treated group at doses of 0.5 and 5.0 μmol/kg (0.25 and 2.5 mg/kg, respectively) exhibited infarct volumes that were significantly lower than those of vehicle-injected rats. at 5.0 μmol/kg, euk-134 reduced the infarct volume by 90% when compared with that of the vehicle controls [1].euk-134 protected most of the vulnerable neurons from excitotoxic cell death.euk-134 significantly reduced (p< 0.05) ka-induced neuronal damage in ca1 (22% of total neurons), an almost complete protection in ca3 (7%) and piriform cortex (14%), indicating that euk-134 prevented most but not all neuronal damage resulting from ka-induced seizure activity [5].

References

[1]. baker k, marcus c b, huffman k, et al. synthetic combined superoxide dismutase/catalase mimetics are protective as a delayed treatment in a rat stroke model: a key role for reactive oxygen species in ischemic brain injury[j]. journal of pharmacology and experimental therapeutics, 1998, 284(1): 215-221.
[2]. jekabsone a, mander p k, tickler a, et al. fibrillar beta-amyloid peptide aβ 1–40 activates microglial proliferation via stimulating tnf-α release and h 2 o 2 derived from nadph oxidase: a cell culture study[j]. journal of neuroinflammation, 2006, 3(1): 1.
[3]. mohammadi m, yazdanparast r. modulation of h2o2‐induced mitogen‐activated protein kinases activation and cell death in sk‐n‐mc cells by euk134, a salenderivative[j]. basic & clinical pharmacology & toxicology, 2011, 108(6): 378-384.
[4]. bahramikia s, yazdanparast r. inhibition of human islet amyloid polypeptide or amylin aggregation by two manganese-salenderivatives[j]. european journal of pharmacology, 2013, 707(1): 17-25.
[5]. rong y, doctrow s r, tocco g, et al. euk-134, a synthetic superoxide dismutase and catalase mimetic, prevents oxidative stress and attenuates kainate-induced neuropathology[j]. proceedings of the national academy of sciences, 1999, 96(17): 9897-9902.

EUK 134 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from EUK 134 manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: SALEN-MN(EUK 134) 81065-76-1
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 98%
Supply Ability: 2000kgs
Release date: 2024-04-18

Henan Fengda Chemical Co., Ltd

Product: EUK-134 81065-76-1
Price: US $30.00-0.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-26

ZhenYiBio Technology Inc

Product: EUK 134 81065-76-1
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500KGS
Release date: 2024-03-26

81065-76-1, EUK 134 Related Search:

ETHYLTRIMETHYLAMMONIUM IODIDE Sodium ethanesulfinate TRIS(2-AMINOETHYL)AMINE Aminosilane Octyl 4-methoxycinnamate Vincristine sulfate Y27632 (hydrochloride) Chlorprothixene Grape Seed Extract Veliparib RG108 Guaiacol EUK 134 N,N'-BIS(SALICYLIDENE)ETHYLENEDIAMINE

CHLORO[[2,2'-[1,2-ETHANEDIYLBIS[(NITRILO-KAPPAN)METHYLIDYNE]]BIS[6-METHOXYPHENOLATO-KAPPAO]]]-MANGANESE

EUK 134

SALEN-MN

ETHYLBISIMINOMETHYLGUAIACOL MANGANESE CHLORIDE

Chloro[[2,2'-[1,2-ethanediylbis(nitrilomethylidyne)]bis[6-methoxyphenolato]](2-)-N2,N2',O1,O1']manganese

SALEN-MN/EUK-134

Manganese (salen-3,3'-diMethoxy) chloride

chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]]]-manganese

(SP-5-13)-Chloro[[2,2′-[1,2-ethanediylbis[(nitrilo-?N)methylidyne]]bis[6-methoxyphenolato-KO]](2-)]-manganese

2,2′-[1,2-Ethanediylbis(nitrilomethylidyne)]bis[6-methoxy-phenol manganese complex

chloro(bis(3,3′di-methoxysalicylidene)ethylenediamine)manganese

EUK 134, SOD/catalase mimetic, Ethylbisiminomethylguaiacol manganese chloride

EUK 134, SOD/catalase mimetic

manganese(2+),2-methoxy-6-[2-[(3-methoxy-2-oxidophenyl)methylideneamino]ethyliminomethyl]phenolate,chloride

SALEN-MN USP/EP/BP

Manganese,chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-kN)methylidyne]]bis[6-methoxyphenolato-kO]](2-)]-,(SP-5-13)-

Salen-Mn-Cl

manganous 2-methoxy-6-[(E)-2-[(E)-(3-methoxy-2-oxido-phenyl)...

(SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]](2-)]manganese

ethylbisiminomethylguaiacol manganese chloride (EUK134)

Manganous 2-methoxy-6-[(E)-2-[(E)-(3-methoxy-2-oxido-phenyl)methyleneamino]ethyliminomethyl]phenolate chloride

Ethylbis aminomethyl Guaiacol manganese chloride

(SP-5-13)-Chloro[[2,2'-[1,2-ethanediylbis[(nitrilo-κN)methylidyne]]bis[6-methoxyphenolato-κO]](2-)]manganese

81065-76-1

C18H18ClMnN2O4

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