ChemicalBook > CAS DataBase List > DBCO-Acid

DBCO-Acid

Product Name
DBCO-Acid
CAS No.
1353016-70-2
Chemical Name
DBCO-Acid
Synonyms
Dibenzocyclooctyne-acid;DBCO-Acid;DBCO-COOH;DBCO acid 1;DBCO-C4-COOH;CAS_1353016-70-2;DBCO-(CH2)2-COOH;Azadibenzocyclooctyne acid;Diphenylcyclooctyne carboxylic acid;[DBCO-COOH] Dibenzocyclooctynes acid
CBNumber
CB62985653
Molecular Formula
C19H15NO3
Formula Weight
305.33
MOL File
1353016-70-2.mol
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DBCO-Acid Property

Melting point:
118-125 °C
Boiling point:
622.0±55.0 °C(Predicted)
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
Soluble in dimethyl sulfoxide and dimethyl formamide.
pka
4.47±0.17(Predicted)
form 
Solid
color 
Off-white to Gray
InChI
InChI=1S/C19H15NO3/c21-18(11-12-19(22)23)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13H2,(H,22,23)
InChIKey
NDLOVDOICXITOK-UHFFFAOYSA-N
SMILES
O=C(C([H])([H])C([H])([H])C(=O)O[H])N1C2=C([H])C([H])=C([H])C([H])=C2C#CC2=C([H])C([H])=C([H])C([H])=C2C1([H])[H]
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Safety

HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Alfa Aesar
Product number
J64549
Product name
Azadibenzocyclooctyne acid
Packaging
25mg
Price
$166
Updated
2023/06/20
Alfa Aesar
Product number
J64549
Product name
Azadibenzocyclooctyne acid
Packaging
100mg
Price
$465
Updated
2023/06/20
TRC
Product number
D194970
Product name
DBCO-Acid
Packaging
100mg
Price
$160
Updated
2021/12/16
Chem-Impex
Product number
35054
Product name
DBCOacid,99%(HPLC)
Purity
99%(HPLC)
Packaging
5MG
Price
$44.8
Updated
2021/12/16
Chem-Impex
Product number
35054
Product name
DBCOacid,≥99%(HPLC)
Purity
≥99%(HPLC)
Packaging
25MG
Price
$99.01
Updated
2021/12/16
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DBCO-Acid Chemical Properties,Usage,Production

Description

DBCO-Acid is a non-activated building block and adds minimal spacer to modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize amine-containing molecules through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-Acid is a reactant in the synthesis of high-generation polyester dendrimers. Also used in the preparation of modular, plasmin sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere systems for creating growth factor gradients in peripheral nerve regeneration.

Application

DBCO-acid (11,12-Didehydro-gamma-oxodibenz[b,f]azocine-5(6H)-butanoic acid) is a cleavable antibody-drug conjugate (ADC) linker used in the synthesis of ADC linkers DBCO-NHS ester (HY-115524 and HY-115545) and drug-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690). DBCO-acid is also a click chemistry reagent that contains a DBCO group in its structure and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group.

General Description

Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne click chemistry reactions. This azadibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

DBCO-Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-Acid Suppliers

China 164 Europe 1 Japan 1 United States 8 Global 174
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
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View Lastest Price from DBCO-Acid manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
DBCO-acid 1353016-70-2
Price
US $0.00/mg
Min. Order
250mg
Purity
>99.00%
Supply Ability
10g
Release date
2024-03-20

1353016-70-2, DBCO-AcidRelated Search:

Dbco-Amine TFA Cy5 DBCO Azadibenzocyclooctyne-Biotin conjugate Oleic-DBCO DBCO-C-PEG1 DBCO-C6-acid BDP FL DBCO DBCO-(CH2)2-NH2-CO-(CH2)2COOH DBCO-amine DBCO-NHS Ester DBCO-(CH2)2-NH2-CO-(CH2)3COOH DBCO-(CH2)3-Acid Hydroxy-PEG2-CH2CO2H 3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid disulfo-ICG-carboxylic acid(tri-sulfo-cy7.5 COOH) Dibenzothiophene DIBENZAZEPINE Phthalan

  • DBCO-Acid
  • Dibenzocyclooctyne-acid
  • 11,12-Didehydro-gamma-oxodibenzo[b,f]azocine-5(6H)-butanoic Acid
  • CAS_1353016-70-2
  • DBCO acid 1
  • 4-{2-azatricyclo[10.4.0.0?,?]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl}-4-oxobutanoic acid
  • Azadibenzocyclooctyne acid
  • DBCO-(CH2)2-COOH
  • 4-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-4-oxobutanoic acid
  • DBCO-C4-COOH
  • Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo-
  • DBCO-Acid (This product is unavailable in the U.S.)
  • 11,12-Didehydro-gamma-oxodibenz[b,f ]azocine-5(6H)-butanoic Acid
  • Dibenz[b,?f]azocine-5(6H)-butanoic acid （DBCO-acid）
  • [DBCO-COOH] Dibenzocyclooctynes acid
  • DBCO-COOH
  • Diphenylcyclooctyne carboxylic acid
  • 11,12-Didehydro-γ-oxodibenz[b,f]azocine-5(6H)-butanoic acid
  • 4-(2-azatricyclo[10.4.0.0^{4,9}]hexadeca-1(12),4,6,8,13,15-hexaen-10-yn-2-yl)-4-oxobutanoic acid
  • 1353016-70-2
  • 714269-57-6
  • 353016-70-2
  • ADC LINKER