DBCO-NHS Ester

Product Name: DBCO-NHS Ester
CAS No.: 1353016-71-3
Chemical Name: DBCO-NHS Ester
Synonyms: N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate;DBCO-NHS;DBCO-NHS ester;CAS_1353016-71-3;Dbco-nhs 98% 100mg;DBCO-NHS Ester (CCT-A133);DBCO-NHS ester, 10 mM in DMSO;DBCO-NHS Ester, ≥98% (CCT-1491);DBCO-NHS ester (DBCO NHS ester);Dibenzocycloctyne n-hydroxysuccinimide
CBNumber: CB23146567
Molecular Formula: C23H18N2O5
Formula Weight: 402.4
MOL File: 1353016-71-3.mol

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DBCO-NHS Ester Property

Boiling point:: 670.2±65.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: Storage temp. -20°C
solubility: Soluble in DMSO, DCM, DMF
pka: -0.23±0.20(Predicted)
form: Solid
color: White to Off-White
Appearance: White solid
Stability:: Moisture Sensitive
InChI: InChI=1S/C23H18N2O5/c26-20(13-14-23(29)30-25-21(27)11-12-22(25)28)24-15-18-7-2-1-5-16(18)9-10-17-6-3-4-8-19(17)24/h1-8H,11-15H2
InChIKey: XCEBOJWFQSQZKR-UHFFFAOYSA-N
SMILES: C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)ON1C(CCC1=O)=O

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Safety

HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: D194965
Product name: DBCO-NHSEster
Packaging: 1mg
Price: $50
Updated: 2021/12/16

Chem-Impex

Product number: 33411
Product name: DBCO-NHSester,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 5MG
Price: $112
Updated: 2021/12/16

BroadPharm

Product number: BP-22231
Product name: DBCO-NHS
Purity: 97%
Packaging: 50mg
Price: $140
Updated: 2021/12/16

Chem-Impex

Product number: 33411
Product name: DBCO-NHSester,98%(HPLC)
Purity: 98%(HPLC)
Packaging: 25MG
Price: $212.8
Updated: 2021/12/16

ChemScene

Product number: CS-0021839
Product name: DBCO-NHSester
Purity: 99.22%
Packaging: 100mg
Price: $215
Updated: 2021/12/16

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DBCO-NHS Ester Chemical Properties,Usage,Production

Description

DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-NHS Ester is a derivative of DBCO (Dibenzylcyclooctyne), used in Cu-free click chemistry. It useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. Used in DNA-Assisted protein analysis such as proximity ligation and extention assays. Intracellular Imaging.

Uses

DBCO NHS ester contains an NHS carbonate group and a DBCO group. The spacer contains a photocleavable nitrobenzyloxyl group, which can be efficiently cleaved under UV to release the conjugated molecules. DBCO on the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.

IC 50

Cleavable Linker

DBCO-NHS Ester Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-NHS Ester Suppliers

China 176 India 1 United States 7 Global 184

Shaanxi Xinyan Bomei Biotechnology Co., Ltd.

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View Lastest Price from DBCO-NHS Ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: DBCO-NHS ester 1353016-71-3
Price: US $0.00/mg
Min. Order: 100mg
Purity: >99.00%
Supply Ability: 1g
Release date: 2024-03-20

1353016-71-3, DBCO-NHS EsterRelated Search:

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DBCO-NHS

N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate

DBCO-NHS ester (DBCO NHS ester)

11,12-Didehydro-γ-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid 2,5-dioxo-1-pyrrolidinyl ester

CAS_1353016-71-3

Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester

4-[(5-aza-3，4:7，8-dibenzocyclooctan-1-yne)-5-yl]-4-oxobutyrate-n-succinimide

Dibenz[b,?f]azocine-5(6H)-butanoic acid,11,12-didehydro-γ-oxo-,2,5-dioxo-1-pyrrolidinyl ester （DBCO-NHS）

DBCO-NHS ester

(2,5-dioxopyrrolidin-1-yl) 4-(2-azatricyclo[10.4.0.0??]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl)-4-oxo-butanoate

2,5-Dioxo-1-pyrrolidinyl-11,12-didehydro-γ-oxodibenz[b,f]azocine-5(6H)-butanoate

Dibenzocycloctyne n-hydroxysuccinimide

DBCO-NHS ester, 10 mM in DMSO

DBCO-NHS Ester, ≥98% (CCT-1491)

DBCO-NHS Ester (CCT-A133)

Dbco-nhs 98% 100mg

N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate[Dbco-NHS

Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester

2,5-Dioxo-1-pyrrolidinyl 11,12-didehydro-oxodibenz[b,f]azocine-5(6H)-butanoate

1353016-71-3

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DBCO