ChemicalBook > CAS DataBase List > DBCO-NHS Ester

DBCO-NHS Ester

Product Name
DBCO-NHS Ester
CAS No.
1353016-71-3
Chemical Name
DBCO-NHS Ester
Synonyms
N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate;DBCO-NHS;DBCO-NHS ester;CAS_1353016-71-3;DBCO-NHS ester (DBCO NHS ester);4-[(5-aza-3，4:7，8-dibenzocyclooctan-1-yne)-5-yl]-4-oxobutyrate-n-succinimide;2,5-Dioxo-1-pyrrolidinyl-11,12-didehydro-γ-oxodibenz[b,f]azocine-5(6H)-butanoate;11,12-Didehydro-γ-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid 2,5-dioxo-1-pyrrolidinyl ester;Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester;Dibenz[b,?f]azocine-5(6H)-butanoic acid,11,12-didehydro-γ-oxo-,2,5-dioxo-1-pyrrolidinyl ester （DBCO-NHS）
CBNumber
CB23146567
Molecular Formula
C23H18N2O5
Formula Weight
402.4
MOL File
1353016-71-3.mol
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DBCO-NHS Ester Property

Boiling point:
670.2±65.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
solubility 
Soluble in DMSO, DCM, DMF
pka
-0.23±0.20(Predicted)
form 
Solid
color 
White to Off-White
Stability:
Moisture Sensitive
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Safety

HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D194965
Product name
DBCO-NHSEster
Packaging
1mg
Price
$50
Updated
2021/12/16
Chem-Impex
Product number
33411
Product name
DBCO-NHSester,98%(HPLC)
Purity
98%(HPLC)
Packaging
5MG
Price
$112
Updated
2021/12/16
BroadPharm
Product number
BP-22231
Product name
DBCO-NHS
Purity
97%
Packaging
50mg
Price
$140
Updated
2021/12/16
Chem-Impex
Product number
33411
Product name
DBCO-NHSester,98%(HPLC)
Purity
98%(HPLC)
Packaging
25MG
Price
$212.8
Updated
2021/12/16
ChemScene
Product number
CS-0021839
Product name
DBCO-NHSester
Purity
99.22%
Packaging
100mg
Price
$215
Updated
2021/12/16
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DBCO-NHS Ester Chemical Properties,Usage,Production

Description

DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-NHS Ester is a derivative of DBCO (Dibenzylcyclooctyne), used in Cu-free click chemistry. It useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. Used in DNA-Assisted protein analysis such as proximity ligation and extention assays. Intracellular Imaging.

Uses

DBCO NHS ester contains an NHS carbonate group and a DBCO group. The spacer contains a photocleavable nitrobenzyloxyl group, which can be efficiently cleaved under UV to release the conjugated molecules. DBCO on the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.

DBCO-NHS Ester Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-NHS Ester Suppliers

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View Lastest Price from DBCO-NHS Ester manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
DBCO-NHS ester 1353016-71-3
Price
US $0.00/mg
Min. Order
100mg
Purity
>99.00%
Supply Ability
1g
Release date
2024-03-20

1353016-71-3, DBCO-NHS EsterRelated Search:

DBCO-maleimide DBCO-PEG1 Dbco-Amine TFA Cy5 DBCO Azadibenzocyclooctyne-Biotin conjugate DBCO-Acid Oleic-DBCO DBCO-C-PEG1 DBCO-C6-acid BDP FL DBCO DBCO-(CH2)2-NH2-CO-(CH2)2COOH DBCO-(CH2)2-NH2-CO-(CH2)3COOH DBCO-(CH2)3-Acid DBCO-Palmitic DBCO-amine DBCO-sulfo-NHS ester DBCO-PEG4-SE DBCO-C6-NHS ester

  • DBCO-NHS
  • N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate
  • DBCO-NHS ester (DBCO NHS ester)
  • 11,12-Didehydro-γ-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid 2,5-dioxo-1-pyrrolidinyl ester
  • CAS_1353016-71-3
  • Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester
  • 4-[(5-aza-3，4:7，8-dibenzocyclooctan-1-yne)-5-yl]-4-oxobutyrate-n-succinimide
  • Dibenz[b,?f]azocine-5(6H)-butanoic acid,11,12-didehydro-γ-oxo-,2,5-dioxo-1-pyrrolidinyl ester （DBCO-NHS）
  • DBCO-NHS ester
  • (2,5-dioxopyrrolidin-1-yl) 4-(2-azatricyclo[10.4.0.0??]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl)-4-oxo-butanoate
  • 2,5-Dioxo-1-pyrrolidinyl-11,12-didehydro-γ-oxodibenz[b,f]azocine-5(6H)-butanoate
  • 1353016-71-3
  • ADC LINKER