ChemicalBook > CAS DataBase List > DBCO-NHS Ester

DBCO-NHS Ester

Product Name
DBCO-NHS Ester
CAS No.
1353016-71-3
Chemical Name
DBCO-NHS Ester
Synonyms
N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate;DBCO-NHS;DBCO-NHS ester;CAS_1353016-71-3;Dbco-nhs 98% 100mg;DBCO-NHS Ester (CCT-A133);DBCO-NHS ester, 10 mM in DMSO;DBCO-NHS Ester, ≥98% (CCT-1491);DBCO-NHS ester (DBCO NHS ester);Dibenzocycloctyne n-hydroxysuccinimide
CBNumber
CB23146567
Molecular Formula
C23H18N2O5
Formula Weight
402.4
MOL File
1353016-71-3.mol
More
Less

DBCO-NHS Ester Property

Boiling point:
670.2±65.0 °C(Predicted)
Density 
1.43±0.1 g/cm3(Predicted)
storage temp. 
Storage temp. -20°C
solubility 
Soluble in DMSO, DCM, DMF
pka
-0.23±0.20(Predicted)
form 
Solid
color 
White to Off-White
Appearance
White solid
Stability:
Moisture Sensitive
InChI
InChI=1S/C23H18N2O5/c26-20(13-14-23(29)30-25-21(27)11-12-22(25)28)24-15-18-7-2-1-5-16(18)9-10-17-6-3-4-8-19(17)24/h1-8H,11-15H2
InChIKey
XCEBOJWFQSQZKR-UHFFFAOYSA-N
SMILES
C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCC(=O)ON1C(CCC1=O)=O
More
Less

Safety

HS Code 
29339900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

TRC
Product number
D194965
Product name
DBCO-NHSEster
Packaging
1mg
Price
$50
Updated
2021/12/16
Chem-Impex
Product number
33411
Product name
DBCO-NHSester,98%(HPLC)
Purity
98%(HPLC)
Packaging
5MG
Price
$112
Updated
2021/12/16
BroadPharm
Product number
BP-22231
Product name
DBCO-NHS
Purity
97%
Packaging
50mg
Price
$140
Updated
2021/12/16
Chem-Impex
Product number
33411
Product name
DBCO-NHSester,98%(HPLC)
Purity
98%(HPLC)
Packaging
25MG
Price
$212.8
Updated
2021/12/16
ChemScene
Product number
CS-0021839
Product name
DBCO-NHSester
Purity
99.22%
Packaging
100mg
Price
$215
Updated
2021/12/16
More
Less

DBCO-NHS Ester Chemical Properties,Usage,Production

Description

DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-NHS Ester is a derivative of DBCO (Dibenzylcyclooctyne), used in Cu-free click chemistry. It useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. Used in DNA-Assisted protein analysis such as proximity ligation and extention assays. Intracellular Imaging.

Uses

DBCO NHS ester contains an NHS carbonate group and a DBCO group. The spacer contains a photocleavable nitrobenzyloxyl group, which can be efficiently cleaved under UV to release the conjugated molecules. DBCO on the other hand readily react with azide bearing biomolecule through a copper-free click reaction instantly and in high yield.
DBCO-NHS Ester is a very popular amine-reactive click chemistry reagent. It can be used to modify an amine-containing molecule in organic solvents (limited solubility in aqueous media). It reacts with primary amines such as the side chain of lysine residues or aminosilane-coated surfaces at neutral or slightly basic pH to form covalent bonds. The low mass weight will add minimal spacer to modified molecules. DBCO is commonly used for copper-free Click Chemistry reactions.

IC 50

Cleavable Linker

DBCO-NHS Ester Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

DBCO-NHS Ester Suppliers

China 176 India 1 United States 7 Global 184
Shaanxi Xinyan Bomei Biotechnology Co., Ltd.
Tel
13892832556
Email
2440688701@qq.com
Country
China
ProdList
1994
Advantage
58
Shanghai Send Pharmaceutical Technology Co., Ltd.
Tel
+86-021-50266790 Q2086672224
Fax
021-50266790
Email
sale@shsendpharm.com
Country
China
ProdList
214
Advantage
50
Shanghai Huasige Pharmaceutical Technology Co., LTD
Tel
13611612777
Email
3627377363@qq.com
Country
China
ProdList
4015
Advantage
58
Shanghai Huici Pharmaceutical Technology Co., LTD
Tel
133-31922809 19372841038
Email
lixing@pharmahuici.com
Country
China
ProdList
732
Advantage
58
Shanghai Jiyi Biological Technology Co., LTD
Tel
021-54135696 18516235431
Fax
50815371
Email
shgegenetech@163.com
Country
China
ProdList
469
Advantage
55
Henan Mengtai Pharmaceutical Technology Co., Ltd
Tel
176345344 7 17634854698
Email
1959525201@qq.com
Country
China
ProdList
10000
Advantage
58
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
39966
Advantage
60
Chemyouth Life Science（Suzhou）Co.,Ltd
Tel
13752065514
Email
jianwei@chemyouth.com
Country
China
ProdList
133
Advantage
58
PharmaBlock Sciences (Nanjing),Inc.
Tel
025-86918202 4000255188
Fax
86-025-86918232
Email
sales@pharmablock.com
Country
China
ProdList
5000
Advantage
55
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14101
Advantage
59
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
7247
Advantage
62
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Aloespharm Co., Ltd.
Tel
021-20960837
Fax
021-20960837
Email
market@aloespharm.com
Country
China
ProdList
1302
Advantage
55
Hygeia (Chengdu) pharmaceutical technique Co., Ltd
Tel
028-84502008 13568869383
Fax
028-66476329
Email
sales@hygeiapharm.com
Country
China
ProdList
296
Advantage
55
ShangHai D&B Biological Science and Technology Co.Ltd
Tel
400-008-9730,021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3057
Advantage
60
Hunan HuaTeng Pharmaceutical Co., Ltd.,
Tel
400-8592883
Fax
0731-82251112
Email
sales@huatengsci.com
Country
China
ProdList
5872
Advantage
58
Shanghai Macklin Biochemical Co.,Ltd.
Tel
15221275939
Fax
021-50706099
Email
shenlinxing@macklin.cn
Country
China
ProdList
15873
Advantage
55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66028182 18626450290
Email
yftan@aikonchem.com
Country
China
ProdList
16679
Advantage
50
skychemical Co.Ltd
Tel
021-20960837,QQ1332204249
Fax
021-20960837
Email
sales@skychemical.com
Country
China
ProdList
3341
Advantage
55
Borenpharm Co., Ltd
Tel
027-65563561
Fax
86-27-59218822
Email
sales@borenpharm.com
Country
China
ProdList
1245
Advantage
55
Shanghai GL Peptide Ltd.
Tel
+86-21-61263340; 17609490614 13764994101
Fax
021-61263399
Email
fisherwang@glschina.com
Country
China
ProdList
8258
Advantage
55
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
NanJing Xienuo bio Co.,Ltd.
Tel
025-84112752 13805181430
Fax
+86-25-84846489
Email
154301870@qq.com
Country
China
ProdList
1000
Advantage
55
Tianjin Kailiqi Biotechnology Co., Ltd.
Tel
15076683720
Fax
022-23754520
Email
klq@cw-bio.com
Country
China
ProdList
8011
Advantage
55
Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
Advantage
58
Wuxi Asia Peptide Biotechnology Limited Company
Tel
0510-83583050 13771062561
Fax
0510-83583039
Email
willsun@peptide-search.com
Country
China
ProdList
6716
Advantage
58
Amadis Chemical Company Limited
Tel
571-89925085
Fax
0086-571-89925065
Email
sales@amadischem.com
Country
China
ProdList
131957
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Dezhou LonWel Pharmaceutical Technology Co., Ltd.
Tel
13761310616
Fax
QQ: 39324283
Email
39324283@qq.com
Country
China
ProdList
1629
Advantage
58
Jiaxing Deyi Chemical Co., Ltd.
Tel
86-0573-85866609 13325730825
Fax
0573-85866609
Email
945717149@qq.com
Country
China
ProdList
8595
Advantage
58
Shanghai 9i Technology Co., Ltd.
Tel
021-33555271 18201009191
Fax
021-33555271
Email
MWen@9iLab.com
Country
China
ProdList
133
Advantage
58
SHANGHAI FDC-CHEMICAL CO.,LTD
Tel
021-61469567 13482353728
Fax
021-61161605
Email
sales@fdc-chemical.com
Country
China
ProdList
9722
Advantage
58
Rhawn Reagent
Tel
400-400-1332688 18019345275
Fax
400-133-2688
Email
amy@rhawn.cn
Country
China
ProdList
14948
Advantage
58
Xi'an Confluore Biological Technology Co., Ltd.
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
Country
China
ProdList
4952
Advantage
58
Shanghai Haohong Pharmaceutical Co., Ltd.
Tel
400-8210725 400821072
Fax
021-58955996
Email
malulu@leyan.com
Country
China
ProdList
25000
Advantage
58
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400-6387771-6039 18920764717
Email
sales@heowns.com
Country
China
ProdList
23771
Advantage
60
UHN Shanghai Research & Development Co., Ltd.
Tel
021-58958002 18930822973
Fax
021-58958618
Email
sales@uhnshanghai.com
Country
China
ProdList
1984
Advantage
58
Zhengzhou Acme Chemical Co., Ltd.
Tel
0371-037163312495,13303845143 13303845143
Fax
QQ3001379618
Email
3001379618@qq.com
Country
China
ProdList
10267
Advantage
58
Abydos Scientific
Tel
025-84767922 18936879710
Email
sales@abydoscientific.com
Country
China
ProdList
1002
Advantage
58
Beijing Minruida Technology Co., Ltd.
Tel
010-82387566 18001021521;
Fax
82387566-801
Email
sales@mreda.com.cn
Country
China
ProdList
10083
Advantage
58
Kanghua (Shanghai) New Drug Development Co., Ltd.
Tel
021-61263370 18901917034
Email
xingli@glbiochem.com
Country
China
ProdList
5637
Advantage
58
Shijiazhuang Dongzhi Chemical Co., Ltd.
Tel
18032763683 13102890206; 18032763683
Fax
QQ：442112647
Email
442112647@qq.com
Country
China
ProdList
300
Advantage
58
Shanghai Jifeng Biotechnology Co., Ltd.
Tel
021-61263377 15023907684
Fax
021-61263399
Email
15800684150@163.com
Country
China
ProdList
8131
Advantage
58
Zhengzhou Alfa Chemical Co.,Ltd
Tel
+8618530059196
Email
sale04@alfachem.cn
Country
China
ProdList
11784
Advantage
58
GL Biochem (Shanghai) Ltd.
Tel
+86-021-61263370 +86-18901917034
Country
CHINA
ProdList
3904
Advantage
58
Labnetwork lnc.
Tel
+86-27-50766799 +8618062016861
Email
contact@labnetwork.com
Country
China
ProdList
19987
Advantage
58
Hangzhou Huarong Pharm Co., Ltd.
Tel
571-86758373 +8613588754946
Fax
0086-571-81131109
Email
sales@huarongpharm.com
Country
CHINA
ProdList
3148
Advantage
58
HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel
86-571-88216897,88216896 13588875226
Fax
86-571-88216895
Email
sales@hzclap.com
Country
CHINA
ProdList
6312
Advantage
58
Career Henan Chemica Co
Tel
+86-0371-86658258 +8613203830695
Fax
0371-86658258
Email
laboratory@coreychem.com
Country
China
ProdList
30229
Advantage
58
Wuhan Borenpharm Co., Ltd
Tel
027-65563561 18717150066
Fax
027-59218822
Email
3207347307@qq.com
Country
CHINA
ProdList
1238
Advantage
58
More
Less

View Lastest Price from DBCO-NHS Ester manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
DBCO-NHS ester 1353016-71-3
Price
US $0.00/mg
Min. Order
100mg
Purity
>99.00%
Supply Ability
1g
Release date
2024-03-20

1353016-71-3, DBCO-NHS EsterRelated Search:

DBCO-Acid DBCO-maleimide DBCO-PEG1 Dbco-Amine TFA Cy5 DBCO Azadibenzocyclooctyne-Biotin conjugate Oleic-DBCO DBCO-C-PEG1 DBCO-C6-acid BDP FL DBCO DBCO-(CH2)2-NH2-CO-(CH2)2COOH DBCO-(CH2)2-NH2-CO-(CH2)3COOH DBCO-(CH2)3-Acid DBCO-Palmitic DBCO-amine DBCO-sulfo-NHS ester DBCO-PEG4-SE DBCO-C6-NHS ester

  • DBCO-NHS
  • N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate
  • DBCO-NHS ester (DBCO NHS ester)
  • 11,12-Didehydro-γ-oxo-dibenz[b,f]azocine-5(6H)-butanoic acid 2,5-dioxo-1-pyrrolidinyl ester
  • CAS_1353016-71-3
  • Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester
  • 4-[(5-aza-3，4:7，8-dibenzocyclooctan-1-yne)-5-yl]-4-oxobutyrate-n-succinimide
  • Dibenz[b,?f]azocine-5(6H)-butanoic acid,11,12-didehydro-γ-oxo-,2,5-dioxo-1-pyrrolidinyl ester （DBCO-NHS）
  • DBCO-NHS ester
  • (2,5-dioxopyrrolidin-1-yl) 4-(2-azatricyclo[10.4.0.0??]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl)-4-oxo-butanoate
  • 2,5-Dioxo-1-pyrrolidinyl-11,12-didehydro-γ-oxodibenz[b,f]azocine-5(6H)-butanoate
  • Dibenzocycloctyne n-hydroxysuccinimide
  • DBCO-NHS ester, 10 mM in DMSO
  • DBCO-NHS Ester, ≥98% (CCT-1491)
  • DBCO-NHS Ester (CCT-A133)
  • Dbco-nhs 98% 100mg
  • N-Succinimidyl 4-[(5-Aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-4-oxobutyrate[Dbco-NHS
  • Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo-, 2,5-dioxo-1-pyrrolidinyl ester
  • 2,5-Dioxo-1-pyrrolidinyl 11,12-didehydro-oxodibenz[b,f]azocine-5(6H)-butanoate
  • 1353016-71-3
  • ADC LINKER
  • DBCO