DBCO-Acid

Product Name: DBCO-Acid
CAS No.: 1353016-70-2
Chemical Name: DBCO-Acid
Synonyms: Dibenzocyclooctyne-acid;DBCO-Acid;DBCO-COOH;DBCO acid 1;DBCO-C4-COOH;DBCO-CH2CH2COOH;CAS_1353016-70-2;DBCO-(CH2)2-COOH;DBCO Acid (CCT-1117);Azadibenzocyclooctyne acid
CBNumber: CB62985653
Molecular Formula: C19H15NO3
Formula Weight: 305.33
MOL File: 1353016-70-2.mol

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DBCO-Acid Property

Melting point:: 118-125 °C
Boiling point:: 622.0±55.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in dimethyl sulfoxide and dimethyl formamide.
pka: 4.47±0.17(Predicted)
form: Solid
color: Off-white to Gray
Appearance: Light grey solid
InChI: InChI=1S/C19H15NO3/c21-18(11-12-19(22)23)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13H2,(H,22,23)
InChIKey: NDLOVDOICXITOK-UHFFFAOYSA-N
SMILES: O=C(C([H])([H])C([H])([H])C(=O)O[H])N1C2=C([H])C([H])=C([H])C([H])=C2C#CC2=C([H])C([H])=C([H])C([H])=C2C1([H])[H]

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Safety

WGK Germany: WGK 3
HS Code: 29339900
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 936375
Product name: DBCO Acid
Purity: ≥95%
Packaging: 100MG
Price: $203
Updated: 2026/03/19

Sigma-Aldrich

Product number: 936375
Product name: DBCO Acid
Purity: ≥95%
Packaging: 250MG
Price: $505
Updated: 2026/03/19

TRC

Product number: D194970
Product name: DBCO-Acid
Packaging: 100mg
Price: $160
Updated: 2021/12/16

Chem-Impex

Product number: 35054
Product name: DBCOacid,99%(HPLC)
Purity: 99%(HPLC)
Packaging: 5MG
Price: $44.8
Updated: 2021/12/16

Chem-Impex

Product number: 35054
Product name: DBCOacid,≥99%(HPLC)
Purity: ≥99%(HPLC)
Packaging: 25MG
Price: $99.01
Updated: 2021/12/16

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DBCO-Acid Chemical Properties,Usage,Production

Description

DBCO-Acid is a non-activated building block and adds minimal spacer to modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize amine-containing molecules through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

DBCO-Acid is a reactant in the synthesis of high-generation polyester dendrimers. Also used in the preparation of modular, plasmin sensitive, clickable poly(ethylene glycol)-heparin-laminin microsphere systems for creating growth factor gradients in peripheral nerve regeneration.

Application

DBCO-acid (11,12-Didehydro-gamma-oxodibenz[b,f]azocine-5(6H)-butanoic acid) is a cleavable antibody-drug conjugate (ADC) linker used in the synthesis of ADC linkers DBCO-NHS ester (HY-115524 and HY-115545) and drug-linker conjugates DBCO-PEG-MMAE (HY-111012 and HY-126690). DBCO-acid is also a click chemistry reagent that contains a DBCO group in its structure and can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing an azide group.

General Description

Acid functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne click chemistry reactions. This azadibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

reaction suitability

reaction type: click chemistry
reagent type: linker

DBCO-Acid Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-Acid Suppliers

China 204 Europe 1 Japan 1 United States 8 Global 214

Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

Tel: 043180534350 19917294565
Email: et@chemextension.com
Country: China
ProdList: 4458
Advantage: 58

Nanjing Bioorth Biotech Co. Ltd

Tel: 18168058751
Email: bioorth@163.com
Country: China
ProdList: 43
Advantage: 58

Shanghai Hope Chem Co., Ltd.，

Tel: +21-18501659228 18501659228
Fax: sales@hope-chem.com
Email: info@hope-chem.com
Country: China
ProdList: 492
Advantage: 55

Chemyouth Life Science（Suzhou）Co.,Ltd

Tel: 18605123100
Email: kaiyuezhang@chemyouth.com
Country: China
ProdList: 143
Advantage: 58

Suzhou Derivative Biotechnology Co., Ltd.

Tel: 13915541704
Email: 2436368162@qq.com
Country: China
ProdList: 574
Advantage: 58

Shanghai Send Pharmaceutical Technology Co., Ltd.

Tel: +86-021-50266790 Q2086672224
Fax: 021-50266790
Email: sale@shsendpharm.com
Country: China
ProdList: 197
Advantage: 50

Shanghai Huici Pharmaceutical Technology Co., LTD

Tel: 133-31922809 19372841038
Email: lixing@pharmahuici.com
Country: China
ProdList: 845
Advantage: 58

Henan Mengtai Pharmaceutical Technology Co., Ltd

Tel: 17634413542
Email: 1959525201@qq.com
Country: China
ProdList: 9999
Advantage: 58

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928;68417696 18306209966;13962195629
Email: linda@highfine.com;minhan.zhao@highfine.com
Country: China
ProdList: 1639
Advantage: 58

PharmaBlock Sciences (Nanjing),Inc.

Tel: 025-86918202 4000255188
Fax: 86-025-86918232
Email: sales@pharmablock.com
Country: China
ProdList: 5000
Advantage: 55

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View Lastest Price from DBCO-Acid manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: DBCO-acid 1353016-70-2
Price: US $0.00/mg
Min. Order: 250mg
Purity: >99.00%
Supply Ability: 10g
Release date: 2024-03-20

1353016-70-2, DBCO-AcidRelated Search:

Dbco-Amine TFA Cy5 DBCO Azadibenzocyclooctyne-Biotin conjugate Oleic-DBCO DBCO-C-PEG1 DBCO-C6-acid BDP FL DBCO DBCO-(CH2)2-NH2-CO-(CH2)2COOH DBCO-amine DBCO-NHS Ester DBCO-(CH2)2-NH2-CO-(CH2)3COOH DBCO-(CH2)3-Acid Hydroxy-PEG2-CH2CO2H 3-[2-(2-Hydroxyethoxy)ethoxy]propanoic acid disulfo-ICG-carboxylic acid(tri-sulfo-cy7.5 COOH) Dibenzothiophene DIBENZAZEPINE Phthalan

DBCO-Acid

Dibenzocyclooctyne-acid

11,12-Didehydro-gamma-oxodibenzo[b,f]azocine-5(6H)-butanoic Acid

CAS_1353016-70-2

DBCO acid 1

4-{2-azatricyclo[10.4.0.0?,?]hexadeca-1(12),4(9),5,7,13,15-hexaen-10-yn-2-yl}-4-oxobutanoic acid

Azadibenzocyclooctyne acid

DBCO-(CH2)2-COOH

4-(11,12-didehydrodibenzo[b,f]azocin-5(6H)-yl)-4-oxobutanoic acid

DBCO-C4-COOH

Dibenz[b,f]azocine-5(6H)-butanoic acid, 11,12-didehydro-γ-oxo-

DBCO-Acid (This product is unavailable in the U.S.)

11,12-Didehydro-gamma-oxodibenz[b,f ]azocine-5(6H)-butanoic Acid

Dibenz[b,?f]azocine-5(6H)-butanoic acid （DBCO-acid）

[DBCO-COOH] Dibenzocyclooctynes acid

DBCO-COOH

Diphenylcyclooctyne carboxylic acid

11,12-Didehydro-γ-oxodibenz[b,f]azocine-5(6H)-butanoic acid

4-(2-azatricyclo[10.4.0.0^{4,9}]hexadeca-1(12),4,6,8,13,15-hexaen-10-yn-2-yl)-4-oxobutanoic acid

11, 12-dihydroγ-oxo-dibenzo [[F] azo-5 -(6H) -butyric acid

11,12-Didehydro-γ-oxodibenz[b,f]azocine-5(6H)-butanoic acid

DBCO Acid (CCT-1117)

DBCO-CH2CH2COOH

1353016-70-2

714269-57-6

353016-70-2

ADC LINKER

DBCO