ChemicalBook > CAS DataBase List > DBCO-amine

DBCO-amine

Product Name
DBCO-amine
CAS No.
1255942-06-3
Chemical Name
DBCO-amine
Synonyms
DBCO-NH2;DBCO-amine;DBCO-CH2CH2NH2;DBCO-(CH2)2-NH2;ADIBO-CH2CH2NH2·TFA;DBCO-(CH2)3-NH2.TFA;DBCO-(CH2)2-NH2.TFA;Dibenzocyclooctyne-amine;DBCO-Amine (DBCO amine);Azadibenzocylooctyne-amine
CBNumber
CB32730210
Molecular Formula
C18H16N2O
Formula Weight
276.33
MOL File
1255942-06-3.mol
More
Less

DBCO-amine Property

Melting point:
86-96°C
Boiling point:
549.9±50.0 °C(Predicted)
Density 
1.25±0.1 g/cm3(Predicted)
storage temp. 
-20°C
pka
8.81±0.10(Predicted)
form 
Solid
color 
Yellow to Orange
InChI
InChI=1S/C18H16N2O/c19-12-11-18(21)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13,19H2
InChIKey
PQFQVUMDOWUGMK-CHMOPDDRSA-N
SMILES
C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCN
More
Less

Safety

WGK Germany 
3
HS Code 
29339900
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
761540
Product name
Dibenzocyclooctyne-amine
Purity
for Copper-free Click Chemistry
Packaging
10mg
Price
$64.2
Updated
2024/03/01
Sigma-Aldrich
Product number
761540
Product name
Dibenzocyclooctyne-amine
Purity
for Copper-free Click Chemistry
Packaging
100mg
Price
$488
Updated
2024/03/01
Alfa Aesar
Product number
J65637
Product name
Azadibenzocyclooctyne-amine
Packaging
25mg
Price
$178
Updated
2024/03/01
Alfa Aesar
Product number
J65637
Product name
Azadibenzocyclooctyne-amine
Packaging
100mg
Price
$473
Updated
2024/03/01
TRC
Product number
D195013
Product name
DBCO-Amine
Packaging
50mg
Price
$900
Updated
2021/12/16
More
Less

DBCO-amine Chemical Properties,Usage,Production

Description

DBCO-amine is a simple building block containing a DBCO moiety and will add minimal spacer to the modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

Azadibenzocyclooctyne amine is a carbonyl reactive reagent used to incorporate ADIBO into organic compounds, surfaces or particlesAzadibenzocyclooctyne amine is widely useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. It reacts with azide functionalized compounds or bimolecules to give stable triazole linkage without a need for a Cu(I) catalyst.

Uses

DBCO-Amine was useful for the study of labelled T-cells, which were used to predict the therapeutic efficacy of adoptive T-cell therapy.

Properties and Applications

DBCO-amine is an aza-dibenzocyclooctyne (DBCO) product used for strain-promoted azide-alkyne cycloaddition (SPAAC, also known as “copper-free click chemistry”). The DBCO moiety reacts selectively with azides via SPAAC to form stable triazole linkages. The amine terminus of the molecule reacts with carboxylic acids and their active esters to form stable amide bonds. Insoluble in water, DBCO-amine is slightly soluble to sparingly soluble in most organic solvents. It recommends dimethylsulfoxide (DMSO), N, N’-dimethylformamide (DMF), or N, N’-dimethylacetamide (DMAC) as solvents for this product. DBCO-amine is relatively insensitive to bases and can be used in the presence of aqueous bases. This product is acid-sensitive. It should not be subjected to pH <5 during reaction or workup. The product should always be stored at -20°C when not in use.

DBCO-amine Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

DBCO-amine Suppliers

China 138 Europe 1 France 1 Germany 3 India 3 Japan 1 United States 16 Global 163
Wanxin Biotechnology (Jiaxing) Co., LTD
Tel
0573-83568680 18057391398
Email
3956524501@qq.com
Country
China
ProdList
1442
Advantage
58
Shaanxi Xinyan Bomei Biotechnology Co., Ltd.
Tel
029-86217788 13892832556
Email
2440688701@qq.com
Country
China
ProdList
1993
Advantage
58
Biomatrik (Jiaxing) Inc.
Tel
573-573-82623377 18967387295
Fax
+86 (573) 8262-3317
Email
sales@biomatrik.cn
Country
China
ProdList
71
Advantage
61
Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd
Tel
0431-80514535 19917294565
Email
caoy@chemextension.com
Country
China
ProdList
4756
Advantage
58
Shaanxi borno biotechnology co., LTD
Tel
+86-13759708231
Email
asherw9@hotmail.com
Country
China
ProdList
2350
Advantage
58
NBC (Shanghai) Chemical Co.,Ltd
Tel
13671558889
Fax
021-56789108
Email
market@nbcchem.com
Country
China
ProdList
184
Advantage
58
Xi'an Confluore Biological Technology Co., Ltd.
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
Country
China
ProdList
4824
Advantage
58
Guangzhou Hongyuan Chemical Co.,Ltd
Tel
15817493340
Email
981810490@qq.com
Country
China
ProdList
1566
Advantage
58
Shanghai Harmony Bio-Pharmaceutical Technology Co., Ltd.
Tel
021-18019086215 18019086215
Email
ljf_navigator@163.com
Country
China
ProdList
802
Advantage
58
Beijing HwrkChemical Technology Co., Ltd
Tel
010-89508211 18501085097
Fax
010-89508210
Email
sales.bj@hwrkchemical.com
Country
China
ProdList
8418
Advantage
55
More
Less

View Lastest Price from DBCO-amine manufacturers

Henan Fengda Chemical Co., Ltd
Product
DBCO-amine 1255942-06-3
Price
US $6.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28
Xian confluore Biological Technology Co., Ltd.
Product
DBCO-amine 1255942-06-3
Price
US $0.00/mg
Min. Order
100mg
Purity
>99.00%
Supply Ability
1g
Release date
2024-03-20

1255942-06-3, DBCO-amineRelated Search:

DBCO-PEG4-maleimide BDP FL DBCO 2-(4-Ethyl-1-piperazinyl)-4-[4-(4-ethyl-1-piperazinyl)phenyl]-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine DBCO-NHS Ester DBCO-sulfo-NHS ester DBCO-PEG4-SE DBCO-C6-NHS ester DBCO-PEG4-biotin DBCO-PEG4-amine DIBENZAZEPINE Dacarbazine DBCO-maleimide DBCO-PEG4-Acid DBCO-PEG3-amine DBCO-PEG5-CH2CH2COOH DBCO-SS-Maleimide DBCO-PEG23-amine DBCO-PEG8-Benzylamine

  • Dibenzocyclooctyne-aMine for Copper-free Click CheMistry
  • ADIBO-CH2CH2NH2·TFA
  • Azadibenzocyclooctyne-(CH2)2-amine TFA
  • DBCO-amine
  • DBCO-NH2
  • Dibenzocyclooctyne-amine
  • DBCO-(CH2)2-NH2.TFA
  • DBCO-(CH2)3-NH2.TFA
  • DBCO-(CH2)2-NH2
  • Azadibenzocyclooctyne-amine
  • Dibenzocyclooctyne-amine (This product is unavailable in the U.S.)
  • 1-Propanone, 3-amino-1-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-
  • 3-amino-1-{2-azatricyclo[10.4.0.0?,?]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl}propan-1-one
  • DBCO-Amine (DBCO amine)
  • Azadibenzocylooctyne-amine
  • 3-Amino-1-[(5-aza-3,4:7,8-dibenzocyclooct-1-yne)-5-yl]-1-propanone
  • 3-Amino-1-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-1-propanone
  • 1-Propanone, 3-amino-1-(11,12-didehydrodibenz[b,?f]azocin-5(6H)-yl)- （DBCO-NH2）
  • ADC,Antibody-drug conjugates linkers,inhibit,non-cleavable,ADC Linkers,Inhibitor,DBCOamine,antibody-drug,DBCO-amine,conjugates,DBCO amine
  • DBCO-CH2CH2NH2
  • 3-amino-1-{10-azatricyclo[10.4.0.04,9]hexadeca-1(16),4(5),6,8,12(13),14-hexaen-2-yn-10-yl}propan-1-one
  • 3-amino-1-(2-azatricyclo[10.4.0.0^{4,9}]hexadeca-1(12),4,6,8,13,15-hexaen-10-yn-2-yl)propan-1-one
  • 1255942-06-3
  • DBCO