DBCO-amine
- Product Name
- DBCO-amine
- CAS No.
- 1255942-06-3
- Chemical Name
- DBCO-amine
- Synonyms
- DBCO-NH2;DBCO-amine;DBCO-C3-NH2;DBCO-CH2CH2NH2;DBCO-(CH2)2-NH2;ADIBO-CH2CH2NH2·TFA;DBCO-(CH2)3-NH2.TFA;DBCO-(CH2)2-NH2.TFA;DBCO Amine (CCT-A103);Azadibenzocyctenylamine
- CBNumber
- CB32730210
- Molecular Formula
- C18H16N2O
- Formula Weight
- 276.33
- MOL File
- 1255942-06-3.mol
DBCO-amine Property
- Melting point:
- 86-96°C
- Boiling point:
- 549.9±50.0 °C(Predicted)
- Density
- 1.25±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml - form
- Solid
- pka
- 8.81±0.10(Predicted)
- color
- Yellow to Orange
- Appearance
- White or light yellow solid
- InChI
- InChI=1S/C18H16N2O/c19-12-11-18(21)20-13-16-7-2-1-5-14(16)9-10-15-6-3-4-8-17(15)20/h1-8H,11-13,19H2
- InChIKey
- PQFQVUMDOWUGMK-CHMOPDDRSA-N
- SMILES
- C(N1CC2=CC=CC=C2C#CC2=CC=CC=C12)(=O)CCN
Safety
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 761540
- Product name
- Dibenzocyclooctyne-amine
- Purity
- for Copper-free Click Chemistry
- Packaging
- 10mg
- Price
- $66.2
- Updated
- 2025/07/31
- Product number
- 761540
- Product name
- Dibenzocyclooctyne-amine
- Purity
- for Copper-free Click Chemistry
- Packaging
- 100mg
- Price
- $503
- Updated
- 2025/07/31
- Product number
- D195013
- Product name
- DBCO-Amine
- Packaging
- 50mg
- Price
- $900
- Updated
- 2021/12/16
- Product number
- D195013
- Product name
- DBCO-Amine
- Packaging
- 5mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 35058
- Product name
- DBCOamine,99%(HPLC)
- Purity
- 99%(HPLC)
- Packaging
- 5MG
- Price
- $56
- Updated
- 2021/12/16
DBCO-amine Chemical Properties,Usage,Production
Description
DBCO-amine is a simple building block containing a DBCO moiety and will add minimal spacer to the modified molecules. In the presence of activators such as EDC or HATU, this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.
Uses
Azadibenzocyclooctyne amine is a carbonyl reactive reagent used to incorporate ADIBO into organic compounds, surfaces or particlesAzadibenzocyclooctyne amine is widely useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. It reacts with azide functionalized compounds or bimolecules to give stable triazole linkage without a need for a Cu(I) catalyst.
Uses
DBCO-Amine was useful for the study of labelled T-cells, which were used to predict the therapeutic efficacy of adoptive T-cell therapy.
reaction suitability
reaction type: click chemistry
reagent type: linker
IC 50
Cleavable Linker
Properties and Applications
DBCO-amine is an aza-dibenzocyclooctyne (DBCO) product used for strain-promoted azide-alkyne cycloaddition (SPAAC, also known as “copper-free click chemistry”). The DBCO moiety reacts selectively with azides via SPAAC to form stable triazole linkages. The amine terminus of the molecule reacts with carboxylic acids and their active esters to form stable amide bonds. Insoluble in water, DBCO-amine is slightly soluble to sparingly soluble in most organic solvents. It recommends dimethylsulfoxide (DMSO), N, N’-dimethylformamide (DMF), or N, N’-dimethylacetamide (DMAC) as solvents for this product. DBCO-amine is relatively insensitive to bases and can be used in the presence of aqueous bases. This product is acid-sensitive. It should not be subjected to pH <5 during reaction or workup. The product should always be stored at -20°C when not in use.
References
[1] YAMAGISHI K, SAWAKI K, MURATA A, et al. A Cu-free clickable fluorescent probe for intracellular targeting of small biomolecules†[J]. Chemical Communications, 2015, 37: 7879-7882. DOI: 10.1039/c4cc09947h
DBCO-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from DBCO-amine manufacturers
- Product
- DBCO-amine 1255942-06-3
- Price
- US $6.00-1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2024-03-28
- Product
- DBCO-amine 1255942-06-3
- Price
- US $0.00/mg
- Min. Order
- 100mg
- Purity
- >99.00%
- Supply Ability
- 1g
- Release date
- 2024-03-20