DBCO-maleimide

Product Name: DBCO-maleimide
CAS No.: 1395786-30-7
Chemical Name: DBCO-maleimide
Synonyms: Dibenzocyclooctyne-maleimide;DBCO-MAL;DBCO-maleimide;DBCO Maleimide (CCT-A108);Dibenzo[a,c]cyclooctyne-maleimide;dibenzenebenzocycloctylyne-acylisoamine;DBCO-Maleimide,Dibenzocyclooctyne-maleimide;DBCO-maleimide (This product is unavailable in the U.S.);DBCO-maleimide (This product is unavailable in the U.S.) (2mg*5);Dibenzocyclooctyne-maleimide (This product is unavailable in the U.S.)
CBNumber: CB92985649
Molecular Formula: C25H21N3O4
Formula Weight: 427.45
MOL File: 1395786-30-7.mol

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DBCO-maleimide Property

Melting point:: 162 °C
Boiling point:: 790.5±60.0 °C(Predicted)
Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO, DCM, DMF
pka: 15.03±0.46(Predicted)
form: Solid
color: Off-white to Gray
Appearance: Light grey solid
InChI: 1S/C25H21N3O4/c29-22(14-16-27-23(30)11-12-24(27)31)26-15-13-25(32)28-17-20-7-2-1-5-18(20)9-10-19-6-3-4-8-21(19)28/h1-8,11-12H,13-17H2,(H,26,29)
InChIKey: NHFQNAGPXIVKND-UHFFFAOYSA-N
SMILES: O=C(N1CCC(NCCC(N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4)=O)=O)C=CC1=O

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Safety

Hazard Codes: N
Risk Statements: 50
Safety Statements: 61
WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Aquatic Acute 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Warning
Hazard statements: H400Very toxic to aquatic life
Precautionary statements: P273Avoid release to the environment.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 760668
Product name: Dibenzocyclooctyne-maleimide
Purity: for Copper-free Click Chemistry
Packaging: 1MG
Price: $37.5
Updated: 2026/03/19

Sigma-Aldrich

Product number: 760668
Product name: Dibenzocyclooctyne-maleimide
Purity: for Copper-free Click Chemistry
Packaging: 5MG
Price: $115
Updated: 2026/03/19

Sigma-Aldrich

Product number: 760668
Product name: Dibenzocyclooctyne-maleimide
Purity: for Copper-free Click Chemistry
Packaging: 50MG
Price: $449
Updated: 2026/03/19

TRC

Product number: A939575
Product name: Dbco-Maleimide
Packaging: 1mg
Price: $40
Updated: 2021/12/16

Chem-Impex

Product number: 35063
Product name: DBCOmaleimide,95%(HPLC)
Purity: 95%(HPLC)
Packaging: 5MG
Price: $56
Updated: 2021/12/16

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DBCO-maleimide Chemical Properties,Usage,Production

Description

DBCO-Maleimide is a sulfhydryl reactive reagent containing a maleimide group and a DBCO moiety. Maleimide group specifically and efficiently reacts with thiols to form thioether bonds. The low mass weight will add minimal spacer to modified molecules and will enable simple and efficient incorporation of DBCO moiety into cysteine-containing peptides or other thiol-containing biomolecules. DBCO is commonly used for copper-free Click Chemistry reactions.

Uses

Maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.

Applications Include:

Protein-peptide conjugates
Antibody-enzyme or antibody-drug conjugates
Protein or peptide-oligonucleotide conjugates
Surface modification

Uses

Dbco-Maleimide is used in preparation of radioactive metal indicator-chelating peptide derivative-conjugated antibodies for medical imaging.

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent

IC 50

Non-cleavable Linker

DBCO-maleimide Preparation Products And Raw materials

Raw materials

Preparation Products

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DBCO-maleimide Suppliers

China 91 Europe 1 India 1 Japan 1 United States 7 Global 101

Suzhou Highfine Biotech Co., Ltd

Tel: 0512-69209928;68417696 18306209966;13962195629
Email: linda@highfine.com;minhan.zhao@highfine.com
Country: China
ProdList: 1639
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
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Adamas Reagent, Ltd.

Tel: 400-6009262 15618770481
Fax: 021-64823266
Email: yhx@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 16055
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Shandong Xiya Chemical Co., Ltd

Tel: 13355009207 13355009207
Fax: 0539-6365991
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Country: China
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TOKYO CHEMICAL INDUSTRY CO., LTD.

Tel: 03-36680489
Fax: 03-3668-0520
Email: Sales-JP@TCIchemicals.com
Country: Japan
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TCI Europe

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Fax: +32 (0)37350701
Email: sales@tcieurope.eu
Country: Europe
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Bide Pharmatech Ltd.

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Shanghai Macklin Biochemical Co.,Ltd.

Tel: 15221275939
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Country: China
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66028182 17714375163
Email: yftan@aikonchem.com
Country: China
ProdList: 16676
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View Lastest Price from DBCO-maleimide manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: DBCO-Maleimide 1395786-30-7
Price: US $0.00/mg
Min. Order: 25mg
Purity: >98.00%
Supply Ability: 250
Release date: 2024-03-20

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DBCO-MAL

N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]-3-(2,5-dioxopyrrol-1-yl)propanamide

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dibenzenebenzocycloctylyne-acylisoamine

1395786-30-7

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