DBCO-PEG4-amine
- Product Name
- DBCO-PEG4-amine
- CAS No.
- 1255942-08-5
- Chemical Name
- DBCO-PEG4-amine
- Synonyms
- DBCO-PEG4-NH2;DBCO-PEG4-amine;DBCO-NHCOPEG4-amine;DBCO-NH-PEG4-CH2CH2NH2;DBCO-NHCO-PEG4-amine TFA salt;Azadibenzocyclooctyne-PEG4-amine;DBCO-PEG4 amine (ADIBO-PEG4-amine);4,7,10,13-Tetraoxapentadecanamide, 15-amino-N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-;3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]propanamide
- CBNumber
- CB53062466
- Molecular Formula
- C29H37N3O6
- Formula Weight
- 523.62
- MOL File
- 1255942-08-5.mol
DBCO-PEG4-amine Property
- Boiling point:
- 784.1±60.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
- pka
- 15.14±0.46(Predicted)
- form
- Solid
- color
- Yellow to Dark Yellow
- Water Solubility
- Soluble in water.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- D194988
- Product name
- DBCO-PEG4-amine
- Packaging
- 1mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- D194988
- Product name
- DBCO-PEG4-amine
- Packaging
- 2.5mg
- Price
- $345
- Updated
- 2021/12/16
- Product number
- 35059
- Product name
- DBCO-PEG-amine
- Purity
- ≥ 95% (HPLC)
- Packaging
- 25MG
- Price
- $180
- Updated
- 2021/12/16
- Product number
- 35059
- Product name
- DBCO-PEG-amine
- Purity
- ≥ 95% (HPLC)
- Packaging
- 100MG
- Price
- $470
- Updated
- 2021/12/16
- Product number
- BP-22292
- Product name
- DBCO-NHCO-PEG4-amineTFAsalt
- Purity
- 98%
- Packaging
- 100mg
- Price
- $495
- Updated
- 2021/12/16
DBCO-PEG4-amine Chemical Properties,Usage,Production
Description
DBCO-NHCO-PEG4-amine is a carboxyl-reactive building block with extended PEG spacer arm. The hydrophilic PEG spacer arm improves water solubility. In the presence of of activators (e.g. EDC, or HATU), this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.
Biological Activity
DBCO-NHCO-PEG4-amine is a PROTAC linker and belongs to the PEG class. It is a cleavable ADC linker that can be used to link MMAE (HY-15162) to antibodies such as DBCO-VCpAB-MMAE and DBCO-TRX-MMAE, with EC50 for SKBR3 cells, respectively 280 nM and 22 nM).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
|