ChemicalBook > CAS DataBase List > DBCO-PEG4-amine

DBCO-PEG4-amine

Product Name
DBCO-PEG4-amine
CAS No.
1255942-08-5
Chemical Name
DBCO-PEG4-amine
Synonyms
DBCO-PEG4-NH2;DBCO-PEG4-amine;DBCO-NHCOPEG4-amine;DBCO-NH-PEG4-CH2CH2NH2;DBCO-NHCO-PEG4-amine TFA;DBCO-PEG4-Amine (CCT-A103P);DBCO-NHCO-PEG4-amine TFA salt;Azadibenzocyclooctyne-PEG4-amine;DBCO-PEG4 amine (ADIBO-PEG4-amine);4,7,10,13-Tetraoxapentadecanamide, 15-amino-N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-
CBNumber
CB53062466
Molecular Formula
C29H37N3O6
Formula Weight
523.62
MOL File
1255942-08-5.mol
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DBCO-PEG4-amine Property

Boiling point:
784.1±60.0 °C(Predicted)
Density 
1.23±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
15.14±0.46(Predicted)
form 
Solid
color 
Yellow to Dark Yellow
Water Solubility 
Soluble in water.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
D194988
Product name
DBCO-PEG4-amine
Packaging
1mg
Price
$160
Updated
2021/12/16
TRC
Product number
D194988
Product name
DBCO-PEG4-amine
Packaging
2.5mg
Price
$345
Updated
2021/12/16
Chem-Impex
Product number
35059
Product name
DBCO-PEG-amine
Purity
≥ 95% (HPLC)
Packaging
25MG
Price
$180
Updated
2021/12/16
Chem-Impex
Product number
35059
Product name
DBCO-PEG-amine
Purity
≥ 95% (HPLC)
Packaging
100MG
Price
$470
Updated
2021/12/16
BroadPharm
Product number
BP-22292
Product name
DBCO-NHCO-PEG4-amineTFAsalt
Purity
98%
Packaging
100mg
Price
$495
Updated
2021/12/16
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DBCO-PEG4-amine Chemical Properties,Usage,Production

Description

DBCO-NHCO-PEG4-amine is a carboxyl-reactive building block with extended PEG spacer arm. The hydrophilic PEG spacer arm improves water solubility. In the presence of of activators (e.g. EDC, or HATU), this reagent can be used to derivatize carboxyl groups or activated esters (e.g. The NHS ester) through a stable amide bond. DBCO is commonly used for copper-free Click Chemistry reactions.

Biological Activity

DBCO-NHCO-PEG4-amine is a PROTAC linker and belongs to the PEG class. It is a cleavable ADC linker that can be used to link MMAE (HY-15162) to antibodies such as DBCO-VCpAB-MMAE and DBCO-TRX-MMAE, with EC50 for SKBR3 cells, respectively 280 nM and 22 nM).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

DBCO-PEG4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from DBCO-PEG4-amine manufacturers

Henan Fengda Chemical Co., Ltd
Product
DBCO-PEG4-amine 1255942-08-5
Price
US $6.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-03-28
Career Henan Chemical Co
Product
DBCO-PEG4-amine 1255942-08-5
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-07-12

1255942-08-5, DBCO-PEG4-amineRelated Search:

Dacarbazine DIBENZAZEPINE DBCO-maleimide DBCO-PEG4-Acid DBCO-PEG3-amine DBCO-PEG5-CH2CH2COOH DBCO-PEG4-maleimide BDP FL DBCO DBCO-PEG4-TAMRA 2-(4-Ethyl-1-piperazinyl)-4-[4-(4-ethyl-1-piperazinyl)phenyl]-5,6,7,8,9,10-hexahydrocycloocta[b]pyridine DBCO-PEG4-biotin DBCO-amine

  • DBCO-PEG4-amine
  • Azadibenzocyclooctyne-PEG4-amine
  • DBCO-NH-PEG4-CH2CH2NH2
  • DBCO-PEG4-NH2
  • 3-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethoxy]-N-[3-(2-azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-3-oxopropyl]propanamide
  • DBCO-PEG4 amine (ADIBO-PEG4-amine)
  • DBCO-NHCOPEG4-amine
  • DBCO-NHCO-PEG4-amine TFA salt
  • 4,7,10,13-Tetraoxapentadecanamide, 15-amino-N-[3-(11,12-didehydrodibenz[b,f]azocin-5(6H)-yl)-3-oxopropyl]-
  • DBCO-NHCO-PEG4-amine TFA
  • DBCO-PEG4-Amine (CCT-A103P)
  • 1255942-08-5
  • 1255942-08-6
  • peg

    • Cleavable

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