3,4-Dibromo-Mal-PEG2-Amine

Product Name: 3,4-Dibromo-Mal-PEG2-Amine
CAS No.: 1807534-86-6
Chemical Name: 3,4-Dibromo-Mal-PEG2-Amine
Synonyms: 3,4-Dibromo-Mal-PEG2-Amine;3,4-Dibromo-Mal-PEG2-Amine TFA salt;1-(2-(2-(2-Aminoethoxy)ethoxy)ethyl)-3,4-dibromo-1H-pyrrole-2,5-dione;1H-Pyrrole-2,5-dione, 1-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-3,4-dibromo-
CBNumber: CB63062276
Molecular Formula: C10H14Br2N2O4
Formula Weight: 386.04
MOL File: 1807534-86-6.mol

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3,4-Dibromo-Mal-PEG2-Amine Property

Boiling point:: 425.1±45.0 °C(Predicted)
Density: 1.831±0.06 g/cm3(Predicted)
solubility: Soluble in Water, DMSO, DCM, DMF
pka: 8.74±0.10(Predicted)

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22011
Product name: 3,4-Dibromo-Mal-PEG2-AmineTFAsalt
Purity: 98%
Packaging: 250mg
Price: $390
Updated: 2021/12/16

Apolloscientific

Product number: BIPG1378
Product name: 3,4-Dibromo-Mal-PEG2-Amine
Packaging: 100mg
Price: $449
Updated: 2021/12/16

BroadPharm

Product number: BP-22011
Product name: 3,4-Dibromo-Mal-PEG2-AmineTFAsalt
Purity: 98%
Packaging: 1g
Price: $870
Updated: 2021/12/16

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3,4-Dibromo-Mal-PEG2-Amine Chemical Properties,Usage,Production

Description

3,4-Dibromo-Mal-PEG2-Amine TFA salt is a PEG linker containing a dibromomaleimide group and a primary amine. The dibromomaleimide group allows for two points of attachement because both of the bromine atoms can be substituted. The primary amine can react with carboxylic acids, activated NHS esters and other carbonyl compounds. PEG linkers are hydrophilic moieties, therefore the attachment of a PEG linker to a compound increases it's water solubility properties in aqueous media.

Uses

3,4-Dibromo-Mal-PEG2-amine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

3,4-Dibromo-Mal-PEG2-Amine Preparation Products And Raw materials

Raw materials

Preparation Products

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3,4-Dibromo-Mal-PEG2-Amine Suppliers

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1807534-86-6, 3,4-Dibromo-Mal-PEG2-AmineRelated Search:

Mal-PEG3-NHS ester Mal-PEG6-COOH N-Succinimidyl 3-maleimidopropionate Mal-PEG4-NHS ester Maleimido-Tri(Ethylene Glycol)-Propionic Acid Mal-PEG2-COOH N-[4-(-Carboxycyclohexylmethyl)]maleimide Mal-PEG4-Acid Mal-PEG2-NHS ester Bis-Mal-Lysine-PEG4-TFP ester Maleimide-PEG4-NHS Ester Maleimide-PEG2-NHS Ester 3-Maleimidopropionic acid Mal-PEG2-acid Mal-Amido-PEG4-acid 2-MALEIMIDOETHYLAMINE HCL 3,4-Dibromo-Mal-PEG2-Boc-Amine 3,4-Dibromo-Mal-PEG4-t-butyl ester

3,4-Dibromo-Mal-PEG2-Amine

3,4-Dibromo-Mal-PEG2-Amine TFA salt

1H-Pyrrole-2,5-dione, 1-[2-[2-(2-aminoethoxy)ethoxy]ethyl]-3,4-dibromo-

1-(2-(2-(2-Aminoethoxy)ethoxy)ethyl)-3,4-dibromo-1H-pyrrole-2,5-dione

1807534-86-6

C10H14Br2N2O4