Amino-PEG36-acid
Appearance Storage Condition- Product Name
- Amino-PEG36-acid
- CAS No.
- 2241751-76-6
- Chemical Name
- Amino-PEG36-acid
- Synonyms
- AMINE-PEG24-COOH;Amino-PEG36-acid;amino-dPEG 12-acid;H2N-PEG36-CH2CH2COOH;NH2-PEG24-CH2CH2COOH;NH2-PEG36-CH2CH2COOH;NH2-PEG(24)-COOH 100MG;Amino-PEG36-CH2CH2COOH;Amino-PEG36-propionic acid;Amino-PEG36-acid (HCl salt)
- CBNumber
- CB63062317
- Molecular Formula
- C75H151NO38
- Formula Weight
- 1675
- MOL File
- 2241751-76-6.mol
Amino-PEG36-acid Property
- Boiling point:
- 1181.6±65.0 °C(Predicted)
- Density
- 1.121±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- form
- solid or viscous liquid
- pka
- 4.28±0.10(Predicted)
- InChIKey
- QKMSNDXWGWBERW-UHFFFAOYSA-N
- SMILES
- C(COCCOCCOCCC(=O)O)OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCN
Safety
- HS Code
- 2918999090
N-Bromosuccinimide Price
- Product number
- BIPG1043
- Product name
- Amino-PEG36-acid
- Packaging
- 100mg
- Price
- $759
- Updated
- 2021/12/16
- Product number
- 432236
- Product name
- H2N-PEG36-CH2CH2COOH
- Purity
- min.97%
- Packaging
- 1g
- Price
- $1000
- Updated
- 2021/12/16
Amino-PEG36-acid Chemical Properties,Usage,Production
Appearance
Amino-PEG24-acid is in solid powder form.
Storage Condition
Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
Description
Amino-PEG24-acid is a PEG derivative containing an amino group with a terminal carboxylic acid. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The terminal carboxylic acid can be reacted with primary amine groups in the presence of activators (e.g. EDC, or DCC) to form a stable amide bond.
Uses
Amino-PEG36-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
General Description
Amino-dPEG?12-acid is a novel amino acid that can be manipulated, modified, and used like most other amino acids. The single molecular weight dPEG? spacer arms between the terminal amine and the terminal carboxylic acid are of exact length (46.5 ?), allowing for precise spatial control, and they are hydrophilic and non-immunogenic, imparting greater water solubility and hydrodynamic volume to target molecules.
reaction suitability
reagent type: cross-linking reagent
reactivity: carboxyl reactive
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
Amino-PEG36-acid Preparation Products And Raw materials
Raw materials
Preparation Products
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