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UNC3230

Product Name
UNC3230
CAS No.
1031602-63-7
Chemical Name
UNC3230
Synonyms
UNC3230;5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide;5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide;2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide;4-Thiazolecarboxamide, 5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-;hyperalgesia,thermal,UNC3230,DRG,antinociceptive,neuron,inhibit,UNC-3230,PIP2,anticancer,glycolysis,PIP4K2C,PIP5K1C,Inhibitor
CBNumber
CB63067589
Molecular Formula
C17H20N4O2S
Formula Weight
344.43
MOL File
1031602-63-7.mol
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UNC3230 Property

storage temp. 
Store at -20°C
solubility 
DMSO:30.0(Max Conc. mg/mL);87.1(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);87.1(Max Conc. mM)
Ethanol:0.2(Max Conc. mg/mL);0.58(Max Conc. mM)
form 
A crystalline solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
16401
Product name
UNC3230
Purity
≥95%
Packaging
1mg
Price
$48
Updated
2024/03/01
Cayman Chemical
Product number
16401
Product name
UNC3230
Purity
≥95%
Packaging
5mg
Price
$117
Updated
2024/03/01
Cayman Chemical
Product number
16401
Product name
UNC3230
Purity
≥95%
Packaging
10mg
Price
$210
Updated
2024/03/01
Cayman Chemical
Product number
16401
Product name
UNC3230
Purity
≥95%
Packaging
50mg
Price
$807
Updated
2024/03/01
Tocris
Product number
5271
Product name
UNC3230
Purity
≥99%(HPLC)
Packaging
50
Price
$844
Updated
2021/12/16
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UNC3230 Chemical Properties,Usage,Production

Description

Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG). Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2. UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM). It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases. At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.

Uses

UNC 3230 is a potent inhibitor of PIP5K1C.

storage

Store at +4°C

UNC3230 Preparation Products And Raw materials

Raw materials

Preparation Products

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UNC3230 Suppliers

China 39 United Kingdom 2 United States 9 USA 1 Global 51
Shanghai Topbiochem Technology Co., Ltd
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Shanghai Lollane Biological Technology Co.,Ltd.
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021-52996696，15000506266 15000506266
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Pharmacodia (Beijing) Co.,Ltd
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+86-400-851-9921
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021-65675885 18964387627
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Tianjin Kailiqi Biotechnology Co., Ltd.
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15076683720
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022-23754520
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klq@cw-bio.com
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Amadis Chemical Company Limited
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571-89925085
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0086-571-89925065
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sales@amadischem.com
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Lynnchem
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86-(0)29-85992781 17792393971
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Dezhou LonWel Pharmaceutical Technology Co., Ltd.
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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sales@chemegen.com
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ShangHai ChuanQian Chemcial Technique Centre
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MedBioPharmaceutical Technology Inc
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021-69568360 18916172912
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order@med-bio.cn
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Changzhou Furuisi Biotechnology Co., Ltd
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Beijing Jin Ming Biotechnology Co., Ltd.
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Bide Pharmatech Ltd.
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TargetMol Chemicals Inc.
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Nanjing Tengyi Biotechnology Co., Ltd
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Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
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Absin Bioscience Inc.
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1031602-63-7, UNC3230Related Search:

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  • UNC3230
  • 2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide
  • 5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide
  • 4-Thiazolecarboxamide, 5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-
  • 5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide
  • hyperalgesia,thermal,UNC3230,DRG,antinociceptive,neuron,inhibit,UNC-3230,PIP2,anticancer,glycolysis,PIP4K2C,PIP5K1C,Inhibitor
  • 1031602-63-7