UNC3230
- Product Name
- UNC3230
- CAS No.
- 1031602-63-7
- Chemical Name
- UNC3230
- Synonyms
- UNC3230;5-(Cyclohexanecarboxamido)-2-(phenylamino)thiazole-4-carboxamide;5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide;2-anilino-5-(cyclohexanecarbonylamino)-1,3-thiazole-4-carboxamide;4-Thiazolecarboxamide, 5-[(cyclohexylcarbonyl)amino]-2-(phenylamino)-;hyperalgesia,thermal,UNC3230,DRG,antinociceptive,neuron,inhibit,UNC-3230,PIP2,anticancer,glycolysis,PIP4K2C,PIP5K1C,Inhibitor
- CBNumber
- CB63067589
- Molecular Formula
- C17H20N4O2S
- Formula Weight
- 344.43
- MOL File
- 1031602-63-7.mol
UNC3230 Property
- storage temp.
- Store at -20°C
- solubility
- DMSO:30.0(Max Conc. mg/mL);87.1(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);87.1(Max Conc. mM)
Ethanol:0.2(Max Conc. mg/mL);0.58(Max Conc. mM) - form
- A crystalline solid
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 16401
- Product name
- UNC3230
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $48
- Updated
- 2024/03/01
- Product number
- 16401
- Product name
- UNC3230
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $117
- Updated
- 2024/03/01
- Product number
- 16401
- Product name
- UNC3230
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $210
- Updated
- 2024/03/01
- Product number
- 16401
- Product name
- UNC3230
- Purity
- ≥95%
- Packaging
- 50mg
- Price
- $807
- Updated
- 2024/03/01
- Product number
- 5271
- Product name
- UNC3230
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $844
- Updated
- 2021/12/16
UNC3230 Chemical Properties,Usage,Production
Description
Phosphatidylinositol-4-phosphate 5-kinase type-1 γ (PIP5K1C) is a lipid kinase that generates phosphatidylinositol-4,5-bisphosphate (PIP2) in nociceptive dorsal root ganglia (DRG). Pain sensitization is regulated by multiple signaling pathways that are initiated by phospholipase C-mediated hydrolysis of PIP2. UNC3230 is a small molecule inhibitor of PIP5K1C (IC50 = 41 nM, Kd = 51 nM). It does not inhibit any other lipid kinases that regulate phosphoinositide levels, including phosphatidylinositol 3-kinases. At 100 nM, UNC3230 decreases PIP2 membrane levels in cultured DRG neurons by 45% and significantly reduces calcium signaling. At 2 nM, it displays antinociceptive effects in mouse models of chronic pain when administered intrathecally or injected into inflamed hindpaw.
Uses
UNC 3230 is a potent inhibitor of PIP5K1C.
storage
Store at +4°C