1,3-Dihydroxyacetone

ChemicalBook > CAS DataBase List > 1,3-Dihydroxyacetone

1,3-Dihydroxyacetone

Product Name: 1,3-Dihydroxyacetone
CAS No.: 96-26-4
Chemical Name: 1,3-Dihydroxyacetone
Synonyms: DIHYDROXYACETONE;1,3-dihydroxypropan-2-one;Dihyxal;Glycerone;Ketochromin;1,3-Dihydroxypropanone;1,3-DIHYDROXY-2-PROPANONE;2-Propanone, 1,3-dihydroxy-;Otan;Aliphatic ketone
CBNumber: CB6306814
Molecular Formula: C3H6O3
Formula Weight: 90.08
MOL File: 96-26-4.mol

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1,3-Dihydroxyacetone Property

Melting point:: 75-80 °C
Boiling point:: 107.25°C (rough estimate)
Density: 1.1385 (rough estimate)
vapor pressure: 0.002-0.33Pa at 20-50℃
refractive index: 1.4540 (estimate)
FEMA: 4033 | DIHYDROXYACETONE
storage temp.: Store at +2°C to +8°C.
solubility: >112.4 mg/mL in DMSO; >5.09 mg/mL in EtOH with ultrasonic
form: powder
pka: 12.45±0.10(Predicted)
color: White
Odor: at 100.00 %. minty
Odor Type: minty
Water Solubility: >250 g/L (20 ºC)
JECFA Number: 1716
Stability:: Stable. Combustible. Hygroscopic.
LogP: -1.95 at 20℃
Surface tension: 68.85mN/m at 1g/L and 20℃
CAS DataBase Reference: 96-26-4(CAS DataBase Reference)
NIST Chemistry Reference: 2-Propanone, 1,3-dihydroxy-(96-26-4)
EPA Substance Registry System: 2-Propanone, 1,3-dihydroxy- (96-26-4)

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Safety

Safety Statements: 24/25
HS Code: 29141900
Hazardous Substances Data: 96-26-4(Hazardous Substances Data)
Toxicity: CHROMELIN ? DIHYDROXYACETONE ? 1,3DIHYDROXYACETONE ? 1,3-DIHYDROXYPROPANONE ? DIHYXAL ? NSC-24343 ? OTAN ? OXATONE ? SOLEAL ? 2PROPANONE, 1,3-DIHYDROXY- ? TRIULOSE ? VITICOLOR

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.20482
Product name: Dihydroxyacetone
Purity: for synthesis
Packaging: 100G
Price: $60.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.20482
Product name: Dihydroxyacetone
Purity: for synthesis
Packaging: 250G
Price: $128
Updated: 2024/03/01

Frontier Specialty Chemicals

Product number: JK368677
Product name: Dihydroxyacetone
Purity: 98%
Packaging: 250g
Price: $144
Updated: 2021/12/16

Matrix Scientific

Product number: 119322
Product name: 1,3-Dihydroxyacetone
Purity: 95+%
Packaging: 500g
Price: $178
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FD07750
Product name: 1,3-Dihydroxyacetone
Packaging: 100g
Price: $200
Updated: 2021/12/16

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1,3-Dihydroxyacetone Chemical Properties,Usage,Production

Chemical Properties

white powder

Chemical Properties

Dihydroxyacetone has a characteristic sweet, cooling aroma.

Occurrence

A derivative of naturally occurring starch

Uses

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Uses

1,3-Dihydroxyacetone can be used as artificial tanning agent.

Uses

1,3-Dihydroxyacetone (DHA) is a self-tanning agent used in cosmetics designed to provide a tanned appearance without the need for sun exposure. It is also a uV protector and a color additive. As a self-tanning agent, it reacts with amino acids found on the skin’s epidermal layer. Its effects last only a few days as the color it provides fades with the natural shedding of the stained cells. Reportedly, it works best on slightly acidic skin. DHA, when combined with lawsone, becomes an FDA Category I (approved) uV protectant. In 1973, the FDA declared that DHA is safe and suitable for use in cosmetics or drugs that are applied to color the skin, and has exempted it from color additive certification.

Definition

ChEBI: Dihydroxyacetone is a ketotriose consisting of acetone bearing hydroxy substituents at positions 1 and 3. The simplest member of the class of ketoses and the parent of the class of glycerones. It has a role as a metabolite, an antifungal agent, a human metabolite, a Saccharomyces cerevisiae metabolite, an Escherichia coli metabolite and a mouse metabolite. It is a ketotriose and a primary alpha-hydroxy ketone.

Preparation

1,3-dihydroxyacetone (DHA) is prepared by acetalization, oxidation, and hydrolysis of glycerol. Usually produced commercially from Bacillus macerans or Bacillus circulans fermentation of starch or starch hydrolysate

Taste threshold values

Reported to have a taste threshold value lower than that of sucrose with a detection level of 3.9 to 27 ppm and a recognition level of 11 to 52 ppm.

General Description

Dihydroxyacetone (DHA) is a browning ingredient widely used in cosmetics such as sunless tanning formulations. It participates in a chemical staining reaction called Milliard reaction in which it reacts with the amino groups of proteins to result in a mixture of high molecular weight pigments.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Safety Profile

Mutation data reported. When heated to decompositionit emits acrid smoke and irritating vapors.

Safety

Cells that were treated with 1,3-Dihydroxyacetone (DHA) showed dose- and time-dependent changes that included cytoplasmic budding, chromatin condensation, and cell detachment. There was a significant decrease in cell proliferation after 24 hours of DHA exposure. After exposure to a 5% DHA solution for 21 days, epidermal thickening and dermatitis of the skin were noted in laboratory animals. After 42 days of treatment with the same solution, hyperplastic and dyskeratotic changes and moderate inflammatory reactions were seen. Long-lasting topical tanning products contain the sugars DHA or erythrulose, which cause a "Maillard reaction" when contacting proteins in the outer layers of the stratum corneum and epidermis. This reaction happens when free amino acids from skin proteins combine with DHA in the stratum corneum. This combination creates the tanned appearance of skin. Results are generally seen within a few hours of application. UV light exposure is not needed to initiate this chemical reaction[1].

References

[1] Gallagher, Mary. “Exposureto Dihydroxyacetone in Sunless Tanning Products.”Journal of the Dermatology Nurses'Association 10(1): 11-17.

1,3-Dihydroxyacetone Preparation Products And Raw materials

Raw materials

Preparation Products

(2,4-DIAMINOPTERIDIN-6-YL)METHANOL HYDROCHLORIDE HYDRATE 6-(Bromomethyl)-2,4-pteridinediamine hydrobromide 4-Imidazolemethanol hydrochloride

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View Lastest Price from 1,3-Dihydroxyacetone manufacturers

Hebei Saisier Technology Co., LTD

Product: 1,3-Dihydroxyacetone 96-26-4
Price: US $6.00/KG
Min. Order: 1KG
Purity: More than 99%
Supply Ability: 2000KG/Month
Release date: 2024-04-29

Hebei Yime New Material Technology Co., Ltd.

Product: 1,3-Dihydroxyacetone 96-26-4
Price: US $40.00/KG
Min. Order: 25KG
Purity: 99
Supply Ability: 1000kg
Release date: 2022-02-22

Chongqing Zhihe Biopharmaceutical Co., Ltd.

Product: Dihydroxyacetone 96-26-4
Price: US $0.00-0.00/kg
Min. Order: 0.10000000149011612kg
Purity: 99%
Supply Ability: 20tons
Release date: 2023-12-25

96-26-4, 1,3-DihydroxyacetoneRelated Search:

Triclosan Solvent Red 43 Hydroxyacetone 3'-Hydroxypropiophenone Citric acid monohydrate Butylated Hydroxytoluene 1-Hydroxyethylidene-1,1-diphosphonic acid Diacetone Alcohol 2,3-Dihydroxypyridine 1,3-Adamantanediol 2,3-Dihydroxybenzoic acid Prednisone CORTISONE Prednisolone Diethyl ketomalonate Furaneol Hydrocortisone fluocinolone16,17-acetonide Dihydroxyacetone

PROPANE-1,3-DIOL-2-ONE

1,3-dihydroxy-2-propanon

1,3-Dihydroxydimethyl ketone

1,3-Dihydroxypropanone

Aliphatic ketone

Chromelin

Dihyxal

Ketochromin

NSC-24343

Otan

Oxantin

Oxatone

Protosol

Soleal

Triulose

Viticolor

DIHYDROXYACETONE

1,3-DIHYDROXYACETONE

1,3-DIHYDROXYACTONE

1,3-DIHYDROXY-2-PROPANE

1,3-DIHYDROXY-2-PROPANONE

1,2-DIHYDROXY-2-PROPANONE

DIHYDROXYACETONE CRYSTALLINE

2-Propanone, 1,3-dihydroxy-

1,3-dihydroxypropan-2-one

1,3-Dihydroxyaceton

Glycerone

1,3-DIHYDROXYACETONE (DHA)

Dihydroxyacetone ,98%

Dihydroxyacetone (250 mg)

1,1-Dihydroxy-propan-2-one

1,3-Dihydroxyacetone, 98%+

1,3-Dihydroxyacetone Monomer

3-Dihydroxyacetone

1,3 Dihydroxypropan-2-One(Dihydroxyacetone)

4-Butylresorcino

DIHYDROXYACETONE FOR SYNTHESIS

Nizatidine Impurity 3

Bis(hydroxymethyl)ketone

dihydroxyacetone (monomer)

1,3-DIHYDROXYACETONE (DHA) Cas RN 96-26-4

1,3-Dihydroxyacetone D4

DHA (Dihydroxyacetone)

Dihydroxyacetone, DHA

Hexane 110-54-3

Glycerol Impurity 15

96-26-4

Pharmaceutical intermediates

Imidazoles

96-26-4

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