ChemicalBook > CAS DataBase List > H-DL-ASP(OME)-OME HCL

H-DL-ASP(OME)-OME HCL

Product Name
H-DL-ASP(OME)-OME HCL
CAS No.
14358-33-9
Chemical Name
H-DL-ASP(OME)-OME HCL
Synonyms
DL-Asp(OMe)-OMe·HCl;H-DL-ASP(OME)-OME HCL;Asciminib Impurity 16;DL-ASPARTIC ACID(OME)-OME HCL;dl-asparticaciddimethylesterHCl;H-DL-ASP(OME)-OME HCL USP/EP/BP;dimethyl 2-aminosuccinate hydrochloride;(1,4-dimethoxy-1,4-dioxobutan-2-yl)azanium;DL-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE;1,4-dimethyl 2-aminobutanedioate hydrochloride
CBNumber
CB6309178
Molecular Formula
C6H12ClNO4
Formula Weight
197.62
MOL File
14358-33-9.mol
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H-DL-ASP(OME)-OME HCL Property

Melting point:
115-116.5℃ (ethanol ethyl acetate )
storage temp. 
Inert atmosphere,2-8°C
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
form 
Powder
color 
White to off-white
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Safety

Hazard Codes 
Xi
Risk Statements 
42/43
Safety Statements 
36/37
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H317May cause an allergic skin reaction

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
D525790
Product name
Dl-AsparticAcidDimethylEsterHydrochloride
Packaging
10g
Price
$75
Updated
2021/12/16
Usbiological
Product number
260705
Product name
DL-Aspartic acid dimethyl ester hydrochloride
Packaging
10g
Price
$333
Updated
2021/12/16
Chem-Impex
Product number
06034
Product name
DL-Asparticaciddimethylesterhydrochloride,98.5%(Assay:Anhydrousbasis)
Purity
98.5%(Assay:Anhydrousbasis)
Packaging
5G
Price
$22.4
Updated
2021/12/16
AK Scientific
Product number
X4316
Product name
DL-Asparticaciddimethylesterhydrochloride
Packaging
25g
Price
$39
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA48715
Product name
DL-Aspartic acid dimethyl ester hydrochloride
Packaging
5G
Price
$65
Updated
2021/12/16
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H-DL-ASP(OME)-OME HCL Chemical Properties,Usage,Production

Chemical Properties

White or off-white crystal

Uses

DL-Aspartic acid dimethyl ester hydrochloride is an aspartic acid derivative[1].

Synthesis

67-56-1

1783-96-6

14358-33-9

106.8 g (0.8 mol) of D-aspartic acid and 700 ml of methanol were added to the reaction vessel, and 84.4 ml (1.2 mol) of thionyl chloride was slowly added dropwise under stirring conditions, with the reaction temperature controlled at 0 °C. After the dropwise addition, the reaction mixture was warmed up to room temperature (about 29°C) and the reaction was continued with stirring for 30 hours. Upon completion of the reaction, excess methanol and thionyl chloride were removed from the reaction solution by distillation. The remaining oily substance was dissolved in 3.5 times the volume of ether for crystallization to obtain white crystals. After filtration, the crystals were washed with ether three times and dried to finally obtain 107.8 g of white solid product DL-aspartic acid dimethyl ester hydrochloride.

Purification Methods

Crystallise it from absolute MeOH. [Kovach et al. J Am Chem Soc 107 7360 1985.] The diethyl ester has pK25 6.4.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

H-DL-ASP(OME)-OME HCL Preparation Products And Raw materials

Raw materials

Preparation Products

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H-DL-ASP(OME)-OME HCL Suppliers

China 72 Germany 1 India 2 Japan 2 Switzerland 2 United Kingdom 3 United States 7 Global 89
Carbosynth
Tel
--
Fax
--
Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
Advantage
58
Leancare Ltd.
Tel
--
Fax
--
Email
enquiry@leancare.co.uk
Country
United Kingdom
ProdList
6446
Advantage
42
Fluorochem Ltd.
Tel
--
Fax
--
Email
enquiries@fluorochem.co.uk
Country
United Kingdom
ProdList
6401
Advantage
74
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View Lastest Price from H-DL-ASP(OME)-OME HCL manufacturers

Sichuan HongRi Pharma-Tech Co.,Ltd
Product
H-DL-Asp(OMe)-OMe·HCl 14358-33-9
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1T+
Release date
2024-03-21
Honest Joy Holdings Limited
Product
H-Dl-asp(ome)-ome hcl 14358-33-9
Price
US $0.00/KG
Min. Order
1KG
Purity
97.9%
Supply Ability
100 tons
Release date
2022-01-26
Sichuan Jiaying Lai Technology Co.,LTD
Product
H-DL-Asp(OMe)-OMe·HCl 14358-33-9
Price
US $1.00/g
Min. Order
1g
Purity
98%
Supply Ability
100KG
Release date
2019-07-25

14358-33-9, H-DL-ASP(OME)-OME HCLRelated Search:

H-ASP(OET)-OET HCL D-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE Dimethyl L-aspartate hydrochloride H-ASP(OTBU)-OTBU HCL DL-Aspartic acid ASPARTIC ACID(OTBU)-ALLYL ESTER HCL H-ASP(OBZL)-OBZL HCL H-ASP(OME)-OTBU HCL H-DL-ASP(OME)-OME HCL H-ASP(OBZL)-OTBU HCL N-ALPHA-CARBOBENZOXY-L-ASPARTIC ACID BETA-T-BUTYL ESTER-ALPHA-BENZYL ESTER HYDROCHLORIDE H-D-Asp(OtBu)-OtBu · HCl FMOC-ASP(OTBU)-2-CHLOROTRITYL RESIN H-D-ASP(OTBU)-ALLYL ESTER HCL H-ASP(OTBU)-OME HCL H-DL-ASP-OME H-L-MEASP(TBU)-OME HCL METHYL 4-BENZYL-6-(3-CHLORO-4-METHOXYPHENYL)-1,3-DIOXOHEXAHYDRO-1H-FURO[3,4-C]PYRROLE-4-CARBOXYLATE

  • DL-ASPARTIC ACID DIMETHYL ESTER HYDROCHLORIDE
  • DL-ASPARTIC ACID(OME)-OME HCL
  • DL-ASPARTIC ACID ALPHA,BETA-DIMETHYL ESTER HYDROCHLORIDE
  • H-DL-ASP(OME)-OME HCL
  • DL-ASPARTIC ACID DIMETHYL ESTERHYDROCHLO RIDE CRYST
  • dl-asparticaciddimethylesterHCl
  • DL-Asp(OMe)-OMe·HCl
  • DL-ASPARTIC ACID A,B-DIMETHYLESTER HYDROCHLORIDE
  • DL-Aspartic acid dimethyl ester hydrochloride≥ 98.5% (Assay: Anhydrous basis)
  • 1,4-dimethyl 2-aminobutanedioate hydrochloride
  • H-DL-ASP(OME)-OME HCL USP/EP/BP
  • (1,4-dimethoxy-1,4-dioxobutan-2-yl)azanium
  • dimethyl 2-aminosuccinate hydrochloride
  • Asciminib Impurity 16
  • 14358-33-9