Epalrestat

Product Name: Epalrestat
CAS No.: 82159-09-9
Chemical Name: Epalrestat
Synonyms: 3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo;2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid;e)-(e;Ipast;Eabeth;Epatat;Ipastat;Epa－API;Kinedak;Epalrest
CBNumber: CB6312501
Molecular Formula: C15H13NO3S2
Formula Weight: 319.4
MOL File: 82159-09-9.mol

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Epalrestat Property

Melting point:: 210-217 C
Boiling point:: 516.8±60.0 °C(Predicted)
Density: 1.43±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: soluble5mg/mL, clear (warmed)
pka: 3.62±0.10(Predicted)
form: powder
color: yellow to orange
Merck: 14,3605
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months.
InChI: InChI=1S/C15H13NO3S2/c1-10(7-11-5-3-2-4-6-11)8-12-14(19)16(9-13(17)18)15(20)21-12/h2-8H,9H2,1H3,(H,17,18)/b10-7+,12-8-
InChIKey: CHNUOJQWGUIOLD-NFZZJPOKSA-N
SMILES: S1/C(=C\C(\C)=C\C2=CC=CC=C2)/C(=O)N(CC(O)=O)C1=S

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Safety

RIDADR: 2811
WGK Germany: 3
RTECS: XJ5131855
HS Code: 2932.99.7000
HazardClass: 6.1
PackingGroup: II

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML0527
Product name: Epalrestat
Purity: ≥98% (HPLC)
Packaging: 10mg
Price: $128
Updated: 2024/03/01

Sigma-Aldrich

Product number: SML0527
Product name: Epalrestat
Purity: ≥98% (HPLC)
Packaging: 50mg
Price: $496
Updated: 2024/03/01

TCI Chemical

Product number: E0906
Product name: Epalrestat
Purity: >98.0%(HPLC)(T)
Packaging: 1g
Price: $135
Updated: 2024/03/01

TCI Chemical

Product number: E0906
Product name: Epalrestat
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $337
Updated: 2024/03/01

Cayman Chemical

Product number: 15214
Product name: Epalrestat
Purity: ≥98%
Packaging: 5mg
Price: $73
Updated: 2024/03/01

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Epalrestat Chemical Properties,Usage,Production

Description

Epalrestat is the second aldose reductase inhibitor to be introduced worldwide and the first to be launched in Japan. The compound is indicated for the treatment of diabetic neuropathy. It is also being investigated for diabetic retinopathy and nephropathy.

Chemical Properties

Red Solid

Originator

Ono (Japan)

Uses

Epalrestat has been used as an aldose reductase inhibitor:

in the dahomey larvae diet fed forDrosophila
for non-irradiated and X-ray irradiated human aldose reductase
to test its protective effect in mice with bleomycin-induced pulmonary fibrosis

Uses

Epalrestat is an aldose reductase inhibitor with IC50 of 72 nM

Uses

An aldose reductase inhibitor. It is used in treatment of diabetic neuropathy.

Definition

ChEBI: A monocarboxylic acid that is 1,3-thiazolidine which is substituted on the nitrogen by a carboxymethyl group, at positions 2 and 4 by thioxo and oxo groups, respectively, and at position 5 by a 2-methyl-3-phenylprop-2-en-1-ylidene group. It is an inhibitor of aldose reductase (which catalyses the conversion of glucose to sorbitol) and is used for the treatment of some diabetic complications, including neuropathy.

brand name

Kinedak

Biochem/physiol Actions

Epalrestat inhibits Aldose Reductase (AR) involved in the rate limiting step in the conversion of glucose to sorbitol under hyperglycemic conditions. Aldose reductase has been the target of multiple clinical investigatons to treat diabetic neuropathy and retinopathy. Epalrestat is an approved drug in Japan and India, used for the treatment of diabetic neuropathy.

References

1) Kikkawa?et al. (1983)?Effect of a new aldose reductase inhibitor, (E)-3-carboxymethyl-5-[(2E)-methyl-3-phenylpropenylidene]rhodanine (ONO-2235), on peripheral nerve disorders in streptozotocin diabetic rats; Diabetologica,?24?290 2) Terashima?et al. (1984)?Effects of a new aldose reductase inhibitor on various tissues in vitro; J. Pharmacol. Exp. Ther.,?229?226 3) Ramirez and Borja (2008)?Epalrestat: an aldose reductase inhibitor for the treatment of diabetic neuropathy; Pharmacotherapy,?28?646

Epalrestat Preparation Products And Raw materials

Raw materials

Concentrated hydrochloric acid Cinnamaldehyde Sodium glycinate Rhodanine-3-acetic acid 1,4-Dioxane Benzaldehyde Acetic acid Sodium chloroacetate

Preparation Products

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Epalrestat Suppliers

Americas 1 Belgium 1 Canada 2 China 352 Europe 4 Germany 6 India 41 Japan 4 Philippines 1 Switzerland 1 Turkey 1 Ukraine 1 United Arab Emirates 1 United Kingdom 12 United States 47 Global 475

Carbosynth

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Molekula Limited

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Manchester Organics

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Sequoia Research Products Ltd

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CMS Chemicals Limited

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CARBONE SCIENTIFIC CO.,LTD

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MOLEKULA Ltd.

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ETA SCIENTIFIC Co.,Ltd

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UK GREEN SCIENTIFIC CO.,LIMITED

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Sequoia Research Products Ltd.

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View Lastest Price from Epalrestat manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: Epalrestat 82159-09-9
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 99%min
Supply Ability: 100KGS
Release date: 2021-07-05

Hebei Weibang Biotechnology Co., Ltd

Product: Epalrestat 82159-09-9
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-29

BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.

Product: Epalrestat 82159-09-9
Price: US $0.00/g
Min. Order: 1g
Purity: More Than 99%
Supply Ability: 100kg/Month
Release date: 2024-11-15

82159-09-9, EpalrestatRelated Search:

2,2'-Dithiobis(benzothiazole) Triphenyltin acetate PHENYL VALERATE Fosthiazate Acetonitrile Methylparaben Methyl acrylate Methyl acetate Kresoxim-methyl Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Paraquat dichloride Basic Violet 1 Benzothiazole Methanol 1-Phenyl-2-nitropropene 4-oxo-2-mercapto-thiazole-3-acetic acid (intermediate of epalrestat) Brexpiprazole 4-oxo-5-[(2E)-3-phenyl-2-propen-1-ylidene]-2-thioxo-, (5Z)-

3-thiazolidineaceticacid,5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo

5-((1z,2e)-2-methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacet

e)-(e

EPALRESTAT

(e,e)-2-[5-(2-methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazo lidin-3-yl]acetic acid

AKOS BBS-00007767

OTAVA-BB BB7211260020

Epalrest

Epalrestat, 99.5%

Epa－API

Ipastat

EPALRESTAT(KINEDAK)

5-[(1Z,2E)-2-METHYL-3-PHENYLPROPENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINEACETICACID(EPALRESTAT)

ONO 2235

Epalresta

2-((E)-5-((E)-2-METHYL-3-PHENYLALLYLIDENE)-4-OXO-2-THIOXOTHIAZOLIDIN-3-YL)ACETIC ACID

Epatrestat

3-Thiazolidineacetic acid, 5-(2-methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-, (E,E)-

5-((1Z,2E)-2-Methyl-3-phenylpropenylidene)-4-oxo-2-thioxo-3-thiazolidineacetic acid

[5-[(1Z,2E)-2-Methyl-3-phenylallylidene]-4-oxo-2-thioxothiazolidin-3-yl]acetic acid

Eabeth

Epatat

Quinedac

Kinedak

(E，E)-5-(2-Methyl-3-phenyl-2-propenylidene)-4-oxo-2-thioxo-3-thiazo-lidineaeetic acid

(5Z)-5-[(2E)-2-Methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-3-thiazolidineacetic Acid

He IpaneMa Division

2-[(5Z)-5[(E)-3-PHENIL-2-METHYLPROP-2-ENYLIDENE]-4-OXO-2-THIOXO-3-THIAZOLIDINYL] ACETIC ACID

2-((Z)-5-((E)-2-Methyl-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl)acetic acid

Epalrestat&gt

Epalrestat Epalrestat

Epalrestat RS

3-Thiazolidineacetic acid, 5-[(2E)-2-methyl-3-phenyl-2-propen-1-ylidene]-4-oxo-2-thioxo-, (5Z)-

Epalrestat USP/EP/BP

Epalrestat (ONO2235)

EpalrestatQ: What is Epalrestat Q: What is the CAS Number of Epalrestat Q: What is the storage condition of Epalrestat Q: What are the applications of Epalrestat

According to Mr He

Antidiabetic API

Ipasetam

Ipast

82159-09-9

81259-09-9

C15H13NO3S2

API

Hormone Drugs

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds

API's

Treatment of diabetic neuropathy

82159-09-9