ChemicalBook > CAS DataBase List > 1-(4-Nitrophenyl)piperazine

1-(4-Nitrophenyl)piperazine

Product Name
1-(4-Nitrophenyl)piperazine
CAS No.
6269-89-2
Chemical Name
1-(4-Nitrophenyl)piperazine
Synonyms
AKOS BBS-00003599;Piperazine-Ph-NO2;RARECHEM AH CK 0146;TIMTEC-BB SBB003475;LABOTEST-BB LT00076049;1-(P-NITROPHENYL)PIPERAZINE;1-(4-NITROPHENYL)PIPERAZINE;1-Nitro-4-piperazinobenzene;N-(4-NITROPHENYL)PIPERAZINE;N-(P-NITROPHENYL) PIPERAZINE
CBNumber
CB6322746
Molecular Formula
C10H13N3O2
Formula Weight
207.23
MOL File
6269-89-2.mol
More
Less

1-(4-Nitrophenyl)piperazine Property

Melting point:
131-133 °C (lit.)
Boiling point:
346.25°C (rough estimate)
Density 
1.1933 (rough estimate)
refractive index 
1.4830 (estimate)
storage temp. 
Storage temp. 2-8°C
form 
Crystalline Powder, Crystals and/or Chunks
pka
8.68±0.10(Predicted)
color 
White to beige to gray
InChI
InChI=1S/C10H13N3O2/c14-13(15)10-3-1-9(2-4-10)12-7-5-11-6-8-12/h1-4,11H,5-8H2
InChIKey
VWOJSRICSKDKAW-UHFFFAOYSA-N
SMILES
N1(C2=CC=C([N+]([O-])=O)C=C2)CCNCC1
CAS DataBase Reference
6269-89-2(CAS DataBase Reference)
NIST Chemistry Reference
N-p-nitrophenylpiperazine(6269-89-2)
More
Less

Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/21/22-36/37/38
Safety Statements 
26-37/39-24/25-36
RIDADR 
2811
WGK Germany 
3
Hazard Note 
Irritant
HazardClass 
6.1
PackingGroup 
III
HS Code 
29335990
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
279773
Product name
1-(4-Nitrophenyl)piperazine
Purity
97%
Packaging
5g
Price
$75.62
Updated
2025/07/31
TCI Chemical
Product number
N0694
Product name
1-(4-Nitrophenyl)piperazine
Purity
>98.0%(T)
Packaging
5g
Price
$29
Updated
2025/07/31
TCI Chemical
Product number
N0694
Product name
1-(4-Nitrophenyl)piperazine
Purity
>98.0%(T)
Packaging
25g
Price
$81
Updated
2025/07/31
TRC
Product number
N504510
Product name
1-(4-Nitrophenyl)piperazine
Packaging
25g
Price
$140
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0016876
Product name
1-(4-NITRO PHENYL )PIPERAZINE
Purity
95.00%
Packaging
10G
Price
$142.8
Updated
2021/12/16
More
Less

1-(4-Nitrophenyl)piperazine Chemical Properties,Usage,Production

Chemical Properties

yellow to ochre powder

Uses

1-(4-Nitrophenyl)piperazine is a useful synthetic intermediate in the synthesis of Itraconazole (I937500); an orally active antimycotic structurally related to Ketoconazole. Also antifungal.

General Description

Inclusion interactions of 1-(4-nitrophenyl)piperazine with 4-sulfonatocalix[n]arenes were investigated by UV spectroscopy and fluorescence spectroscopy.

Synthesis

110-85-0

100-00-5

6269-89-2

A solution of 1-chloro-4-nitrobenzene (650 g, 4.140 mol) in diethylene glycol dimethyl ether (1 L) was slowly added dropwise to a solution of piperazine (2.84 Kg, 33.12 mol) in diethylene glycol dimethyl ether (500 mL) at 100 °C. The reaction mixture was stirred continuously at 100°C for 6 hours. Upon completion of the reaction, the mixture was cooled to 40-45 °C and water (5 L) was slowly added to quench the reaction. Subsequently, the mixture was warmed to room temperature and stirring was continued for 1 hour. The precipitated solid was collected by filtration, washed sequentially with water (1 L) and petroleum ether (500 mL), and dried to give 700 g (81% yield) of 4-nitrophenylpiperazine as a yellow solid. [TLC detection conditions: ethyl acetate:petroleum ether (3:7); Rf value: 0.70].

References

[1] Tetrahedron Letters, 1999, vol. 40, # 31, p. 5655 - 5659
[2] Organic Letters, 2016, vol. 18, # 20, p. 5272 - 5275
[3] Patent: WO2016/79536, 2016, A1. Location in patent: Page/Page column 34-35
[4] Patent: WO2017/203270, 2017, A1. Location in patent: Page/Page column 30; 33; 34
[5] Patent: WO2018/45106, 2018, A1. Location in patent: Paragraph 00133

1-(4-Nitrophenyl)piperazine Preparation Products And Raw materials

Raw materials

Preparation Products

4-(1-Acetylpiperazin-4-yl)phenol
More
Less

1-(4-Nitrophenyl)piperazine Suppliers

Americas 1 Belgium 1 Canada 1 China 166 Europe 3 Germany 10 India 22 Italy 1 Japan 8 Poland 1 Russia 1 Slovakia 1 Switzerland 3 The Netherlands 1 Ukraine 1 United Kingdom 18 United States 53 Global 292
Pure Chemistry Scientific Inc.
Tel
001-857-928-2050 or 1-888-588-9418
Fax
001-617-206-9595
Email
sales@chemreagents.com
Country
United States
ProdList
10186
Advantage
62
RR Scientific LLC
Tel
+86-13917743231
Email
sales@rrscientific.com
Country
United States
ProdList
878
Advantage
58
Alchem Pharmtech,Inc.
Tel
8485655694
Email
sales@alchempharmtech.com
Country
United States
ProdList
63687
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
Ambeed, Inc.
Tel
--
Fax
--
Email
info@ambeed.com
Country
United States
ProdList
502
Advantage
58
Combi-Blocks, Inc.
Tel
--
Fax
--
Email
les@combi-blocks.com
Country
United States
ProdList
2555
Advantage
58
Alichem Inc.
Tel
--
Fax
--
Email
sales@alichem.com
Country
United States
ProdList
6167
Advantage
58
TCI America, Inc. (part of Tokyo Chemical Industry)
Tel
--
Fax
--
Email
Angelina.Crew@tcichemicals.com
Country
United States
ProdList
2053
Advantage
58
Glentham Life Sciences Ltd
Tel
--
Fax
--
Email
info@glentham.com
Country
United States
ProdList
2026
Advantage
58
Tyger Scientific Inc.
Tel
--
Fax
--
Email
sales@tygersci.com
Country
United States
ProdList
402
Advantage
58
eNovation Chemicals LLC
Tel
--
Fax
--
Email
ales@eNovationChem.com
Country
United States
ProdList
1673
Advantage
58
AstaTech, Inc.
Tel
--
Fax
--
Email
sales@astatechinc.com
Country
United States
ProdList
904
Advantage
58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
Advantage
58
Accela ChemBio Inc.
Tel
--
Fax
--
Email
info@accelachem.com
Country
United States
ProdList
1054
Advantage
50
Aurum Pharmatech, LLC
Tel
--
Fax
--
Email
sales@aurumpharmatech.com
Country
United States
ProdList
498
Advantage
0
OChem Incorporation
Tel
--
Fax
--
Email
sales@ocheminc.com
Country
United States
ProdList
6501
Advantage
60
Parchem Fine & Specialty Chemicals
Tel
--
Fax
--
Email
info@parchem.com
Country
United States
ProdList
1031
Advantage
58
Combi-Blocks Inc.
Tel
--
Fax
--
Email
sales@combi-blocks.com
Country
United States
ProdList
6618
Advantage
69
SynQuest Laboratories, Inc.
Tel
--
Fax
--
Email
info@synquestlabs.com
Country
United States
ProdList
6871
Advantage
62
Riedel-de Haen AG
Tel
--
Fax
--
Country
United States
ProdList
6773
Advantage
87
TCI America
Tel
--
Fax
--
Email
sales@tciamerica.com
Country
United States
ProdList
6909
Advantage
75
Frontier Scientific, Inc.
Tel
--
Fax
--
Email
sales@frontiersci.com
Country
United States
ProdList
6222
Advantage
86
Matrix Scientific
Tel
--
Fax
--
Email
sales@matrixscientific.com
Country
United States
ProdList
6632
Advantage
80
Alfa Chemistry
Tel
--
Fax
--
Email
info@Alfa-Chemistry.com
Country
United States
ProdList
6814
Advantage
0
ChemContract Research Inc.
Tel
--
Fax
--
Country
United States
ProdList
1526
Advantage
38
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6962
Advantage
56
Aagile Labs Division of Tyger Scientific
Tel
--
Fax
--
Email
tygersci@yahoo.com
Country
United States
ProdList
6568
Advantage
68
AlliChem, LLC
Tel
--
Fax
--
Email
sales@allichemllc.com
Country
United States
ProdList
6516
Advantage
60
Waterstone Technology, LLC
Tel
--
Fax
--
Email
sales@waterstonetech.com
Country
United States
ProdList
6786
Advantage
30
D-L Chiral Chemicals, LLC
Tel
--
Fax
--
Country
United States
ProdList
977
Advantage
42
Ryan Scientific, Inc.
Tel
--
Fax
--
Email
ryan.reichlyn@ryansci.com
Country
United States
ProdList
6439
Advantage
60
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
Advantage
65
Oakwood Products, Inc.
Tel
--
Fax
--
Email
sales@oakwoodchemical.com
Country
United States
ProdList
6193
Advantage
74
2A PharmaChem USA
Tel
--
Fax
--
Email
sales@2apharmachem.com
Country
United States
ProdList
6137
Advantage
39
AllChem Laboratories
Tel
--
Fax
--
Email
allchemlab@sify.com
Country
United States
ProdList
263
Advantage
38
3B Scientific Corporation
Tel
--
Fax
--
Email
sales@3bsc.com
Country
United States
ProdList
6718
Advantage
47
HONEST JOY HOLDINGS LIMITED
Tel
--
Fax
--
Email
sales@honestjoy.cn
Country
United States
ProdList
6675
Advantage
54
APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
Advantage
38
Syntech Labs
Tel
--
Fax
--
Email
info@syntechlabs.com
Country
United States
ProdList
730
Advantage
43
Sciencelab.com, Inc.
Tel
--
Fax
--
Email
accounting@sciencelab.com
Country
United States
ProdList
4159
Advantage
82
Advance Scientific & Chemical
Tel
--
Fax
--
Email
sales@advance-scientific.com
Country
United States
ProdList
6419
Advantage
71
Davos Chemical Corporation
Tel
--
Fax
--
Email
info@davos.com
Country
United States
ProdList
1640
Advantage
65
ChemPacific Corporation
Tel
--
Fax
--
Email
sales@chempacific.com
Country
United States
ProdList
6891
Advantage
51
Alfa Aesar
Tel
--
Fax
--
Email
tech@alfa.com
Country
United States
ProdList
6814
Advantage
81
Spectrum Chemicals & Laboratory Products
Tel
--
Fax
--
Email
sales@spectrumchemical.com
Country
United States
ProdList
6699
Advantage
77
Acros Organics USA
Tel
--
Fax
--
Email
eveleth@fisherchem.com
Country
United States
ProdList
3846
Advantage
81
American Custom Chemicals Corporation
Tel
--
Fax
--
Email
sales@acccorporation.com
Country
United States
ProdList
6820
Advantage
51
BOSCHE SCIENTIFIC, LLC
Tel
--
Fax
--
Email
Sales@BoscheSci.com
Country
United States
ProdList
6477
Advantage
55
Aagami, Inc.
Tel
--
Fax
--
Email
dinesh@aagami.net
Country
United States
ProdList
557
Advantage
42
Atlantic SciTech Group, Inc.
Tel
--
Fax
--
Email
sales@astginc.com
Country
United States
ProdList
2308
Advantage
43
More
Less

View Lastest Price from 1-(4-Nitrophenyl)piperazine manufacturers

ShenZhen H&D Pharmaceutical Technology Co., LTD
Product
Palbociclib Impurity 14 6269-89-2
Price
US $0.00-0.00/mg
Min. Order
10mg
Purity
98%
Supply Ability
500mg
Release date
2024-08-12
Shaanxi Dideu New Materials Co. Ltd
Product
1-(4-Nitrophenyl)piperazine 6269-89-2
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-02-19
Zhuozhou Wenxi import and Export Co., Ltd
Product
1-(4-Nitrophenyl)piperazine 6269-89-2
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11

6269-89-2, 1-(4-Nitrophenyl)piperazineRelated Search:

1-Phenyl-2-nitropropene N-Aminoethylpiperazine Piperacillin 2-Ethylhexyl ferulate Piperazine 1-(2-CHLORO-4-NITROPHENYL)-PIPERAZINE 4-Nitro-7-(1-piperazinyl)-2,1,3-benzoxadiazole Propiophenone 1-Acetyl-4-(4-nitrophenyl)piperazine 1-METHYL-4-(4-NITROPHENYL)PIPERAZINE 1-(3-Nitrophenyl)piperazin-2-one 1-(4-METHOXYPHENYL)-4-(4-NITROPHENYL)PIPERAZINE 1-Methyl-4-(3-nitrophenyl)piperazine ,97% 1-(3-NITROPHENYL)-PIPERAZINE 1-(4-HYDROXYPHENYL)-4-(4-NITROPHENYL)-PIPERAZINE 1-(2,4-DINITROPHENYL)-PIPERAZINE HCL 1-(2-NITROPHENYL)PIPERAZINE,1-(2-Nitrophenyl)piperazine ,98% 1-(2-CHLORO-4-NITROPHENYL)-3-METHYLPIPERAZINE HYDROCHLORIDE

  • Piperazine-Ph-NO2
  • 1-(4-nitrophenyl)piperazin-4-ium
  • AKOS BBS-00003599
  • 1-(P-NITROPHENYL)PIPERAZINE
  • 1-NITRO-4-(1-PIPERAZINYL)BENZENE
  • 1-(4-NITROPHENYL)PIPERAZINE
  • 1-(4-NITRO-PHENYL)-PIPERAZINE DIHYDROCHLORIDE
  • 1-(4-NITROPHENYL)PIPERAZINE HCL
  • LABOTEST-BB LT00076049
  • 1-(4-Nitrophenyl)piperazine 97%
  • N-(P-NITROPHENYL) PIPERAZINE
  • 1-(4-Nitrophenyl)piperazine, 98+%
  • 1-Nitro-4-piperazinobenzene
  • 1-Nitro-4-(piperazin-1-yl)benzene, 4-(Piperazin-1-yl)nitrobenzene
  • Piperazine, 1-(4-nitrophenyl)-
  • N-(4-NITROPHENYL)PIPERAZINE
  • RARECHEM AH CK 0146
  • TIMTEC-BB SBB003475
  • 1-(4-Nitrophenyl)piperazine&gt
  • 4-Nitrophenyl piperazine, 97%
  • 1-(4-Nitrophenyl)piperazine - [N93451]
  • 6269-89-2
  • C10H14N3O2
  • C0H13N3O2
  • AMINE
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperazines
  • CHIRAL CHEMICALS
  • Phenyls & Phenyl-Het
  • Building Blocks
  • Heterocyclic Building Blocks
  • Piperazines
  • Nitrogen cyclic compounds
  • Piperidines, Piperidones, Piperazines
  • pharmacetical
  • Phenyls & Phenyl-Het
  • Piperaizine
  • API intermediates