ChemicalBook > CAS DataBase List > (R)-(+)-1-Boc-3-aminopyrrolidine

(R)-(+)-1-Boc-3-aminopyrrolidine

Product Name
(R)-(+)-1-Boc-3-aminopyrrolidine
CAS No.
147081-49-0
Chemical Name
(R)-(+)-1-Boc-3-aminopyrrolidine
Synonyms
tert-butyl (R)-3-aminopyrrolidine-1-carboxylate;(R)-TERT-BUTYL 3-AMINOPYRROLIDINE-1-CARBOXYLATE;TERT-BUTYL (3R)-3-AMINOPYRROLIDINE-1-CARBOXYLATE;(R)-(+)-1-Boc-3-aMin;(R)-3-Amino-1-Boc-pyrroli...;(R)-1-BOC-3-AMINOPYRROLIDINE;1-Boc-3-(R )-aminopyrrolidine;(R)-3-AMINO-1-BOC-PYRROLIDINE;(R)-3-AMINO-N-BOC-PYRROLIDINE;R-1-N-BOC-3-AMINO PYRROLIDINE
CBNumber
CB6331979
Molecular Formula
C9H18N2O2
Formula Weight
186.25
MOL File
147081-49-0.mol
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(R)-(+)-1-Boc-3-aminopyrrolidine Property

Melting point:
243-244°C
Boiling point:
243-244°C
Density 
1.098
refractive index 
1.4720
Flash point:
196°F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
form 
Liquid
pka
9.55±0.20(Predicted)
color 
Clear pale yellow
Sensitive 
Air Sensitive
InChI
InChI=1S/C9H18N2O2/c1-9(2,3)13-8(12)11-5-4-7(10)6-11/h7H,4-6,10H2,1-3H3/t7-/m1/s1
InChIKey
CMIBWIAICVBURI-SSDOTTSWSA-N
SMILES
N1(C(OC(C)(C)C)=O)CC[C@@H](N)C1
CAS DataBase Reference
147081-49-0(CAS DataBase Reference)
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Safety

Hazard Codes 
C,Xn
Risk Statements 
22-41-44
Safety Statements 
26-36/37/39
RIDADR 
UN 2810 6.1/PG 3
WGK Germany 
3
HazardClass 
6.1
PackingGroup 
Ⅲ
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
644064
Product name
(R)-(+)-1-Boc-3-aminopyrrolidine
Purity
97%
Packaging
5g
Price
$223
Updated
2025/07/31
Sigma-Aldrich
Product number
644064
Product name
(R)-(+)-1-Boc-3-aminopyrrolidine
Purity
97%
Packaging
1g
Price
$58.7
Updated
2023/06/20
TCI Chemical
Product number
B2920
Product name
(3R)-(+)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$35
Updated
2025/07/31
TCI Chemical
Product number
B2920
Product name
(3R)-(+)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$165
Updated
2025/07/31
TRC
Product number
B630108
Product name
(R)-1-Boc-3-AminopyrrolidineCitrate
Packaging
50mg
Price
$60
Updated
2021/12/16
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(R)-(+)-1-Boc-3-aminopyrrolidine Chemical Properties,Usage,Production

Chemical Properties

Colorless to light yellow liqui

Uses

(R)-(+)-1-Boc-3-aminopyrrolidine may be used to prepare:

  • Descarboxamide analog and Na-methylated analogs of 4-N-(Nω-nitro-L-argininyl)-trans-4-amino-L-proline amide.
  • Histamine 3 (H3) receptor antagonists containing pyrrolidin-3-yl-N-methylbenzamide moiety.

Synthesis

143700-04-3

147081-49-0

A mixture of tert-butyl (R)-3-azido pyrrolidine-1-carboxylate (250 mg, 1.18 mmol) and Pd/C (50 mg, 10% w/w) in methanol (10 mL) was reacted with stirring at room temperature for 12 h under hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration and the filtrate was concentrated to afford tert-butyl (R)-3-aminopyrrolidine-1-carboxylate as a colorless liquid (210 mg, 96% yield). The product was characterized by 1H NMR (600 MHz, CDCl3): δ 3.33-3.49 (m, 3H), 3.27-3.32 (m, 1H), 2.95-3.03 (m, 1H), 1.98-2.08 (m, 1H), 1.63-1.70 (m, 1H), 1.41 (s, 9H). Mass spectrometry (MS-ESI) analysis showed: m/z 131.20 [M-55]+.

References

[1] Patent: WO2016/34134, 2016, A1. Location in patent: Paragraph 00508
[2] Patent: CN105399698, 2016, A. Location in patent: Paragraph 1493-1495
[3] Patent: US2009/221565, 2009, A1. Location in patent: Page/Page column 50
[4] Advanced Synthesis and Catalysis, 2009, vol. 351, # 14-15, p. 2288 - 2294
[5] Tetrahedron, 2009, vol. 65, # 41, p. 8513 - 8523

(R)-(+)-1-Boc-3-aminopyrrolidine Preparation Products And Raw materials

Raw materials

Ethanol Calcium chloride Di-tert-butyl dicarbonate Benzyltrimethylammonium chloride Sodium borohydride Triethylamine Palladium Methanesulfonyl chloride 1,4-Dioxane D-Aspartic acid Tetrahydrofuran 4-Nitrobenzyl chloroformate Dichloromethane Benzyl chloroformate Acetic acid Methanol Sodium hydroxide Allylamine Pyridine Thionyl chloride

Preparation Products

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View Lastest Price from (R)-(+)-1-Boc-3-aminopyrrolidine manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
(R)-(+)-1-Boc-3-aminopyrrolidine 147081-49-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-26
Nanjing Fred Technology Co., Ltd
Product
(R)-(+)-1-Boc-3-aminopyrrolidine 147081-49-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1 ton
Release date
2024-01-03
Honest Joy Holdings Limited
Product
(R)-(+)-1-BOC-3-Aminopyrrolidine 147081-49-0
Price
US $0.00/KG
Min. Order
1KG
Purity
98.4%
Supply Ability
100 tons
Release date
2022-01-26

147081-49-0, (R)-(+)-1-Boc-3-aminopyrrolidineRelated Search:

N-Vinyl-2-pyrrolidone tert-Butyl peroxyacetate Pyrrolidine Polyvinylpyrrolidone N-Methyl-2-pyrrolidone tert-Butanol 3-Aminopyrrolidine tert-Butyl acetate METHYL-2-PYRROLIDONE (2S,4R)-1-BOC-4-AMINO-PYRROLIDINE-2-CARBOXYLIC ACID N-Boc-trans-4-amino-L-proline methyl ester hydrochloride L-N-[(4'-BOC)PIPERIDINO]PROLINE N-Boc-4-oxo-L-Proline methyl ester 1-BOC-3-AMINOPYRROLIDINE,DL-3-Amino-1-N-Boc-Pyrrolidine 1-N-Boc-3-Aminopyrrolidine (S)-(-)-1-tert-Butoxycarbonyl-3-aminopyrrolidine BOC-(+/-)-3-AMINOPYRROLIDINE (R)-1-Boc-3-(aminomethyl)pyrrolidine (R)-3-Aminopyrrolidine

  • 1-Boc-3-(R )-aminopyrrolidine
  • (R)-3-Amino-1-Boc-pyrroli...
  • (3R)-3-Aminopyrrolidine, N1-BOC protected
  • 1-PYRROLIDINECARBOXYLIC ACID, 3-AMINO-, 1,1-DIMETHYLETHYL ESTER, (3R)
  • 3-AMINO-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, (R)
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  • 1-t-butoxycarbonyl-3-R-aMinopyrrolidine
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  • tert-Butyl (3R)-3-aminopyrrolidine-1-carboxylate, (3R)-3-Amino-1-(tert-butoxycarbonyl)pyrrolidine
  • (R)-(+)-1-Boc-3-aMinopyrrolidine SynonyMs (R)-(+)-N-Boc-3-aMinopyrrolidine
  • (R)-(+)-1-Boc-3-aMinopyrrolidine, ee: 98%
  • tert-Butyl (3R)-3-aMinopyrrolidine-1-carboxylate, >95%
  • (R)-(+)-1-Boc-3-aminopyrrolidine 97%
  • (R)-(+)-1-Boc-3-aminopyrrolidine, >=98%
  • (R)-(+)-1-tert-Butoxycarbonyl-3-aminopyrrolidine
  • (R)-N-Boc-3-aminopyrrolidine,99%e.e.
  • (R)-(+)-1-Boc-3-aminopyrrolidine, 97%, ee: 98%
  • (R)-(+)-N-tert-Butoxycarbonyl-3-aminopyrrolidine
  • TERT-BUTYL (3R)-3-AMINOPYRROLIDINE-1-CARBOXYLATE
  • (R)-3-AMINO-1-BOC-PYRROLIDINE
  • (R)-3-AMINO-1-N-(T-BUTOXYCARBONYL)PYRROLIDINE
  • (R)-3-AMINO-1-TERT-BUTOXYCARBONYLPYRROLIDINE
  • (R)-3-AMINO-1-N-BOC-PYRROLIDINE
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  • (R)-1-Boc-3-(aminomethyl)pyrrolidine HCl
  • (R)-(+)-N-BOC-3-aminopyrrolidine,97%
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  • tert-butyl (R)-3-aminopyrrolidine-1-carboxylate
  • (3R)-(+)-1-(tert-Butoxycarbonyl)-3-aminopyrrolidine &gt
  • 147081-49-0 (R)-(+)-1-Boc-3-aminopyrrolidine
  • (<i>R</i>)-(+)-1-Boc-3-aminopyrrolidine
  • 147081-49-0
  • 117081-49-0
  • Chiral Building Blocks
  • Asymmetric Synthesis
  • Heterocyclic Building Blocks
  • Pyrrolidines
  • 3-Aminopyrrolidines
  • Chiral 3-Aminopyrrolidines