ChemicalBook > CAS DataBase List > 2-Methoxyethoxymethyl chloride

2-Methoxyethoxymethyl chloride

Product Name
2-Methoxyethoxymethyl chloride
CAS No.
3970-21-6
Chemical Name
2-Methoxyethoxymethyl chloride
Synonyms
MEM CHLORIDE;1-CHLOROMETHOXY-2-METHOXYETHANE;MEM Chlordie;MEM chloride,94%;2-Methoxyethoxymethy;2-MethoxyethoxymethyL;1-Chloro-2,5-dioxahexane;Roxithromycin side chain;Roxithromycin Impurity 15;ALKOXYETHOXYMETHYLCHLORIDE
CBNumber
CB6332734
Molecular Formula
C4H9ClO2
Formula Weight
124.57
MOL File
3970-21-6.mol
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2-Methoxyethoxymethyl chloride Property

Melting point:
200-202 °C
Boiling point:
50-52 °C/13 mmHg (lit.)
Density 
1.091 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.427(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Chloroform, Methanol
form 
Liquid
Specific Gravity
1.091
color 
Clear colorless to yellow
Water Solubility 
It hydrolyzes with water.
Sensitive 
Moisture Sensitive
BRN 
1900576
Exposure limits
ACGIH: TWA 0.001 ppm
InChIKey
BIAAQBNMRITRDV-UHFFFAOYSA-N
CAS DataBase Reference
3970-21-6(CAS DataBase Reference)
NIST Chemistry Reference
«BETA»-methoxyethoxymethyl chloride(3970-21-6)
EPA Substance Registry System
Ethane, 1-(chloromethoxy)-2-methoxy- (3970-21-6)
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Safety

Hazard Codes 
T
Risk Statements 
45-10-36/37/38-20/21/22-46-40-23/24/25-20/22
Safety Statements 
53-26-36/37/39-45-16-23
RIDADR 
UN 2810 6.1/PG 2
WGK Germany 
3
F 
10-21
Hazard Note 
Toxic
TSCA 
Yes
HazardClass 
3
PackingGroup 
III
HS Code 
29091990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

H350May cause cancer

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
357480
Product name
2-Methoxyethoxymethyl chloride
Purity
technical grade
Packaging
5g
Price
$77.2
Updated
2024/03/01
Sigma-Aldrich
Product number
357480
Product name
2-Methoxyethoxymethyl chloride
Purity
technical grade
Packaging
25g
Price
$194
Updated
2024/03/01
TCI Chemical
Product number
M0680
Product name
2-Methoxyethoxymethyl Chloride
Purity
>95.0%(GC)
Packaging
25mL
Price
$78
Updated
2024/03/01
TCI Chemical
Product number
M0680
Product name
2-Methoxyethoxymethyl Chloride
Purity
>95.0%(GC)
Packaging
500mL
Price
$597
Updated
2024/03/01
Alfa Aesar
Product number
L01050
Product name
2-Methoxyethoxymethyl chloride, 94%
Packaging
5g
Price
$45.65
Updated
2024/03/01
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2-Methoxyethoxymethyl chloride Chemical Properties,Usage,Production

Chemical Properties

CLEAR COLOURLESS LIQUID

Uses

2-Methoxyethoxymethyl chloride, is used as selectively cleaved under aprotic conditions in the presence of a wide range of OH-protected reagents. It is used as an OH-protecting reagent. An examples of the target molecule MEM Chloride is the side chain of roxithromycin. It is also used in the protection of the OH groups in serine and threonine during peptide synthesis. Some of the other applications include have the ability to coordinate to metals, which is thought to accelerate the cleavage by Lewis acids. The chelating ability of the MEM ether also makes it useful as a stereodirecting group in organometallic reactions, first noted in the stereo controlled addition of ?-methoxyvinyllithium to a carbonyl in the synthesis of taxusin.

Uses

OH-protecting reagent. MEM ethers are stable to a variety of reaction conditions and are selectively cleaved under aprotic conditions in the presence of a wide rangeof OH-protected moieties.

Uses

2-Methoxyethoxymethyl Chloride is an OH-protecting reagent. 2-Methoxyethoxymethyl Chloride is used in the modification of antibiotics.

Purification Methods

Possible impurities are methoxyethanol (b 124o/atm), HCHO and HCl which can be removed below the boiling point of MEMCl. Purify MEMCl by fractional distillation in a vacuum. If too impure, prepare it from methoxyethanol (152g) and s-trioxane (66g) by bubbling a stream of dry HCl (with stirring) until a clear mixture is obtained. Dilute with pentane (900mL), dry (3hours over 100g MgSO4, at 5o), evaporate and the residue is distilled in a vacuum. It is MOISTURE SENSITIVE and TOXIC. The MEM.NEt3+Cl-salt, prepared by reaction with 1.3 equivalents of Et3N (16hours/25o) and dried in a vacuum, has m 58-61o, and is moisture sensitive. [Corey et al. Tetrahedron Lett 809 1976, Yoshimatsu et al. J Org Chem 59 1011 1994, Greene & Wuts Protective Groups in Organic Synthesis edn, J Wiley & Sons NY 1991.] Carcinogen.

2-Methoxyethoxymethyl chloride Preparation Products And Raw materials

Raw materials

Preparation Products

Roxithromycin 3,4-DIBROMO-5-HYDROXY-5H-FURAN-2-ONE
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2-Methoxyethoxymethyl chloride Suppliers

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View Lastest Price from 2-Methoxyethoxymethyl chloride manufacturers

airuikechemical co., ltd.
Product
2-methoxyethoxymethyl chloride 3970-21-6
Price
US $0.00-0.00/Kg
Min. Order
1Kg
Purity
99.9%
Supply Ability
200tons
Release date
2024-03-28
Hebei Mojin Biotechnology Co., Ltd
Product
2-Methoxyethoxymethyl chloride 3970-21-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2023-10-09
Hebei Guanlang Biotechnology Co., Ltd.
Product
2-Methoxyethoxymethyl chloride 3970-21-6
Price
US $30.00-10.00/KG
Min. Order
50KG
Purity
99%
Supply Ability
500000kg
Release date
2023-03-22

3970-21-6, 2-Methoxyethoxymethyl chlorideRelated Search:

Mepiquat chloride 4-Methoxybenzylchloride Sodium chloride tert-Butyldimethylsilyl chloride Polyvinyl chloride Choline chloride Ammonium chloride Calcium chloride Benzyl chloride Ethoxymethylenemalononitrile DIMETHYLTHEXYLSILYL CHLORIDE 4-(Chloromethyl)benzoic acid Methylene Chloride 2-Ethoxyethyl chloroformate 1-Chloro-3,5-di-O-toluoyl-2-deoxy-D-ribofuranose TRIETHYLENE GLYCOL BIS(CHLOROFORMATE) 2-METHOXYETHYL CHLOROFORMATE Oxydiethylene bis(chloroformate)

  • ALKOXYETHOXYMETHYLCHLORIDE
  • BETA-METHOXYETHOXYMETHYL CHLORIDE
  • ETHYLENE GLYCOL CHLOROMETHYL METHYL ETHER
  • MEM CHLORIDE
  • 1-CHLOROMETHOXY-2-METHOXYETHANE
  • 1-(Chloromethoxy)-2-methoxyethane~MEM chloride
  • Alcoxyethoxymethylchloride
  • Methoxxxy ethoxy Chloromethane
  • 2-Methoxyethoxymethyl chloride, technical grade
  • 2-METHOXYETHOXYMETHYL CHLORIDE
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  • MEM CHLORIDE (2-METHOXYETHOXYMETHYL CHLORIDE)
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  • MEM chloride,94%
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  • 1-(2-pyridinylsulfonyl)benzotriazole
  • 2,5-Dioxahexyl chloride, tech
  • MEM chloride, 1-(Chloromethoxy)-2-methoxyethane, 2-Methoxyethoxymethyl chloride
  • 1-Chloromethoxy-2-methoxyethane Ethylene Glycol Chloromethyl Methyl Ether MEM-Chloride
  • MethoxyethoxyMethylchlorid
  • 1-(chloromethoxy)-2-methoxy-ethan
  • 1-Chloro-2,5-dioxahexane
  • 2-Methoxy-1-(Chloromethoxy)
  • Ethane, 1-(chloromethoxy)-2-methoxy-
  • Chloride:Alcoxyethoxylmethylchloride
  • 2-MethoxyethoxymethylChloride&gt
  • 2-Methoxyethoxymethyl chloride, 95%, for synthesis
  • 2-MethoxyethoxymethyL
  • β-Methoxyethoxymethyl Chloride Or Mem-Chloride
  • 2-Methoxyethyl chloromethyl ether
  • 2-Methoxyethoxychloromethane
  • Roxithromycin side chain
  • Roxithromycin Impurity 15
  • 3970-21-6
  • CH3OCH2CH2OCH2Cl
  • CH3OCH22OCH2Cl
  • C4H9ClO2
  • Protection and Derivatization
  • Protecting and Derivatizing Reagents
  • Others
  • Synthetic Reagents
  • Protection & Derivatization Reagents (for Synthesis)
  • Protection & Derivatization Reagents (for Synthesis)
  • Synthetic Organic Chemistry