2-Methoxyethoxymethyl chloride
- Product Name
- 2-Methoxyethoxymethyl chloride
- CAS No.
- 3970-21-6
- Chemical Name
- 2-Methoxyethoxymethyl chloride
- Synonyms
- MEM CHLORIDE;1-CHLOROMETHOXY-2-METHOXYETHANE;MEM Chlordie;MEM chloride,94%;2-Methoxyethoxymethy;2-MethoxyethoxymethyL;1-Chloro-2,5-dioxahexane;Roxithromycin side chain;Roxithromycin Impurity 15;ALKOXYETHOXYMETHYLCHLORIDE
- CBNumber
- CB6332734
- Molecular Formula
- C4H9ClO2
- Formula Weight
- 124.57
- MOL File
- 3970-21-6.mol
2-Methoxyethoxymethyl chloride Property
- Melting point:
- 200-202 °C
- Boiling point:
- 50-52 °C/13 mmHg (lit.)
- Density
- 1.091 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.427(lit.)
- Flash point:
- >230 °F
- storage temp.
- 2-8°C
- solubility
- Chloroform, Methanol
- form
- Liquid
- Specific Gravity
- 1.091
- color
- Clear colorless to yellow
- Water Solubility
- It hydrolyzes with water.
- Sensitive
- Moisture Sensitive
- BRN
- 1900576
- Exposure limits
- ACGIH: TWA 0.001 ppm
- InChIKey
- BIAAQBNMRITRDV-UHFFFAOYSA-N
- CAS DataBase Reference
- 3970-21-6(CAS DataBase Reference)
- NIST Chemistry Reference
- «BETA»-methoxyethoxymethyl chloride(3970-21-6)
- EPA Substance Registry System
- Ethane, 1-(chloromethoxy)-2-methoxy- (3970-21-6)
Safety
- Hazard Codes
- T
- Risk Statements
- 45-10-36/37/38-20/21/22-46-40-23/24/25-20/22
- Safety Statements
- 53-26-36/37/39-45-16-23
- RIDADR
- UN 2810 6.1/PG 2
- WGK Germany
- 3
- F
- 10-21
- Hazard Note
- Toxic
- TSCA
- Yes
- HazardClass
- 3
- PackingGroup
- III
- HS Code
- 29091990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H226Flammable liquid and vapour
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H331Toxic if inhaled
H335May cause respiratory irritation
H350May cause cancer
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313IF exposed or concerned: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 357480
- Product name
- 2-Methoxyethoxymethyl chloride
- Purity
- technical grade
- Packaging
- 5g
- Price
- $77.2
- Updated
- 2024/03/01
- Product number
- 357480
- Product name
- 2-Methoxyethoxymethyl chloride
- Purity
- technical grade
- Packaging
- 25g
- Price
- $194
- Updated
- 2024/03/01
- Product number
- M0680
- Product name
- 2-Methoxyethoxymethyl Chloride
- Purity
- >95.0%(GC)
- Packaging
- 25mL
- Price
- $78
- Updated
- 2024/03/01
- Product number
- M0680
- Product name
- 2-Methoxyethoxymethyl Chloride
- Purity
- >95.0%(GC)
- Packaging
- 500mL
- Price
- $597
- Updated
- 2024/03/01
- Product number
- L01050
- Product name
- 2-Methoxyethoxymethyl chloride, 94%
- Packaging
- 5g
- Price
- $45.65
- Updated
- 2024/03/01
2-Methoxyethoxymethyl chloride Chemical Properties,Usage,Production
Chemical Properties
CLEAR COLOURLESS LIQUID
Uses
2-Methoxyethoxymethyl chloride, is used as selectively cleaved under aprotic conditions in the presence of a wide range of OH-protected reagents. It is used as an OH-protecting reagent. An examples of the target molecule MEM Chloride is the side chain of roxithromycin. It is also used in the protection of the OH groups in serine and threonine during peptide synthesis. Some of the other applications include have the ability to coordinate to metals, which is thought to accelerate the cleavage by Lewis acids. The chelating ability of the MEM ether also makes it useful as a stereodirecting group in organometallic reactions, first noted in the stereo controlled addition of ?-methoxyvinyllithium to a carbonyl in the synthesis of taxusin.
Uses
OH-protecting reagent. MEM ethers are stable to a variety of reaction conditions and are selectively cleaved under aprotic conditions in the presence of a wide rangeof OH-protected moieties.
Uses
2-Methoxyethoxymethyl Chloride is an OH-protecting reagent. 2-Methoxyethoxymethyl Chloride is used in the modification of antibiotics.
Purification Methods
Possible impurities are methoxyethanol (b 124o/atm), HCHO and HCl which can be removed below the boiling point of MEMCl. Purify MEMCl by fractional distillation in a vacuum. If too impure, prepare it from methoxyethanol (152g) and s-trioxane (66g) by bubbling a stream of dry HCl (with stirring) until a clear mixture is obtained. Dilute with pentane (900mL), dry (3hours over 100g MgSO4, at 5o), evaporate and the residue is distilled in a vacuum. It is MOISTURE SENSITIVE and TOXIC. The MEM.NEt3+Cl-salt, prepared by reaction with 1.3 equivalents of Et3N (16hours/25o) and dried in a vacuum, has m 58-61o, and is moisture sensitive. [Corey et al. Tetrahedron Lett 809 1976, Yoshimatsu et al. J Org Chem 59 1011 1994, Greene & Wuts Protective Groups in Organic Synthesis edn, J Wiley & Sons NY 1991.] Carcinogen.
2-Methoxyethoxymethyl chloride Preparation Products And Raw materials
Raw materials
Preparation Products
2-Methoxyethoxymethyl chloride Suppliers
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- Country
- Ukraine
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View Lastest Price from 2-Methoxyethoxymethyl chloride manufacturers
- Product
- 2-Methoxyethoxymethyl chloride 3970-21-6
- Price
- US $30.00-10.00/KG
- Min. Order
- 50KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-11-04
- Product
- 2-methoxyethoxymethyl chloride 3970-21-6
- Price
- US $0.00-0.00/Kg
- Min. Order
- 1Kg
- Purity
- 99.9%
- Supply Ability
- 200tons
- Release date
- 2024-03-28
- Product
- 2-Methoxyethoxymethyl chloride 3970-21-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2023-10-09