3-Bromo-4-methylpyridine
- Product Name
- 3-Bromo-4-methylpyridine
- CAS No.
- 3430-22-6
- Chemical Name
- 3-Bromo-4-methylpyridine
- Synonyms
- 4-Meth;yihebio;3-BROMO-4-PICOLINE;Bromomethylpyridine;3-Bromo-4-methylpyri;3-BROMO-4-METHYLPYRIDINE;4-METHYL-3-BROMOPYRIDINE;3-Bromo-4-methylpyridins;Pyridine, 3-broMo-4-Methyl-;3--4- MethylpyridinebroMide
- CBNumber
- CB6338781
- Molecular Formula
- C6H6BrN
- Formula Weight
- 172.02
- MOL File
- 3430-22-6.mol
3-Bromo-4-methylpyridine Property
- Boiling point:
- 199-200 °C(lit.)
- Density
- 1.549 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.56(lit.)
- Flash point:
- 175 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform, Methanol
- pka
- 3.54±0.18(Predicted)
- form
- Liquid
- Specific Gravity
- 1.549
- color
- Clear colorless to yellow
- BRN
- 878354
- InChI
- InChI=1S/C6H6BrN/c1-5-2-3-8-4-6(5)7/h2-4H,1H3
- InChIKey
- GSQZOLXWFQQJHJ-UHFFFAOYSA-N
- SMILES
- C1=NC=CC(C)=C1Br
- CAS DataBase Reference
- 3430-22-6(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-2636
- RIDADR
- Cool, dry,tightly closed
- WGK Germany
- 3
- HazardClass
- IRRITANT
- PackingGroup
- III
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 548030
- Product name
- 3-Bromo-4-methylpyridine
- Purity
- 96%
- Packaging
- 1g
- Price
- $30.1
- Updated
- 2023/06/20
- Product number
- 548030
- Product name
- 3-Bromo-4-methylpyridine
- Purity
- 96%
- Packaging
- 5g
- Price
- $77.7
- Updated
- 2023/06/20
- Product number
- B2831
- Product name
- 3-Bromo-4-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $16
- Updated
- 2025/07/31
- Product number
- B2831
- Product name
- 3-Bromo-4-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $33
- Updated
- 2025/07/31
- Product number
- B2831
- Product name
- 3-Bromo-4-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $98
- Updated
- 2025/07/31
3-Bromo-4-methylpyridine Chemical Properties,Usage,Production
Chemical Properties
Clear Liquid
Uses
An intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity
Uses
3-Bromo-4-methylpyridine may be used as a building block in the preparation of:
- substituted 4-(2,2-diphenylethyl)pyridine-N-oxides for use as potent phosphodiesterase type 4 (PDE4) inhibitors
- benzodiazepine site ligands bearing tricyclic pyridone moiety for human GABAA receptor
- a novel isomer of ascididemin
- 3-bromopyridine-4-carbonitrile
Synthesis
108-89-4
3430-22-6
The general procedure for the synthesis of 4-methyl-3-bromopyridine from 4-methylpyridine was as follows: 0.054 mol of 4-methylpyridine was added to a 60 mL constant pressure dropping funnel. Under nitrogen protection and stirring conditions at room temperature, it was slowly added dropwise to a mixture consisting of 0.07 mol AlCl3 and 0.01 mol potassium bromide, and the reaction mixture was stirred for 1 hour. A condensing unit was installed, heated to 120°C, and 0.07 mol of bromine was added slowly dropwise for about 1 hour dropwise. Heating and stirring were continued at 120°C for 26 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and slowly poured into crushed ice with stirring. The pH was adjusted to neutral by the addition of sodium hydroxide solution and stirred until completely dissolved. The aqueous layer was extracted with dichloromethane, the organic layers were combined and the solvent was recovered by steam distillation. The resulting oily product was purified by column chromatography (eluent ratio of VP petroleum ether: ethyl acetate = 6:1) to give 5.3 g of 3-bromo-4-methylpyridine in the form of a tan oil with a purity of 99.9% and a yield of 57%.
References
[1] Patent: CN106243022, 2016, A. Location in patent: Paragraph 0067-0069
[2] Patent: WO2014/97150, 2014, A1. Location in patent: Page/Page column 22-23
[3] Patent: US2005/80085, 2005, A1. Location in patent: Page/Page column 12
[4] Patent: US5294610, 1994, A
3-Bromo-4-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
3-Bromo-4-methylpyridine Suppliers
- Tel
- 800-4238616
- Fax
- +1-888-520-1075 / +1-503-283-1987
- sales@tciamerica.com
- Country
- Americas
- ProdList
- 23653
- Advantage
- 75
View Lastest Price from 3-Bromo-4-methylpyridine manufacturers
- Product
- 3-Bromo-4-methylpyridine 3430-22-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
- Product
- 3-Bromo-4-methylpyridine 3430-22-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-31
- Product
- 3-Bromo-4-methylpyridine 3430-22-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27