ChemicalBook > CAS DataBase List > 3-Bromo-4-methylpyridine
3-Bromo-4-methylpyridine
- Product Name
- 3-Bromo-4-methylpyridine
- CAS No.
- 3430-22-6
- Chemical Name
- 3-Bromo-4-methylpyridine
- Synonyms
- 4-Meth;yihebio;3-BROMO-4-PICOLINE;Bromomethylpyridine;3-Bromo-4-methylpyri;3-BROMO-4-METHYLPYRIDINE;4-METHYL-3-BROMOPYRIDINE;3-Bromo-4-methylpyridins;Pyridine, 3-broMo-4-Methyl-;3--4- MethylpyridinebroMide
- CBNumber
- CB6338781
- Molecular Formula
- C6H6BrN
- Formula Weight
- 172.02
- MOL File
- 3430-22-6.mol
More
Less
3-Bromo-4-methylpyridine Property
- Boiling point:
- 199-200 °C(lit.)
- Density
- 1.549 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.56(lit.)
- Flash point:
- 175 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Chloroform, Methanol
- pka
- 3.54±0.18(Predicted)
- form
- Liquid
- Specific Gravity
- 1.549
- color
- Clear colorless to yellow
- BRN
- 878354
- InChI
- InChI=1S/C6H6BrN/c1-5-2-3-8-4-6(5)7/h2-4H,1H3
- InChIKey
- GSQZOLXWFQQJHJ-UHFFFAOYSA-N
- SMILES
- C1=NC=CC(C)=C1Br
- CAS DataBase Reference
- 3430-22-6(CAS DataBase Reference)
More
Less
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-36-2636
- RIDADR
- Cool, dry,tightly closed
- WGK Germany
- 3
- HazardClass
- IRRITANT
- PackingGroup
- III
- HS Code
- 29339900
More
Less
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
More
Less
N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 548030
- Product name
- 3-Bromo-4-methylpyridine
- Purity
- 96%
- Packaging
- 1g
- Price
- $30.1
- Updated
- 2023/06/20
Sigma-Aldrich
- Product number
- 548030
- Product name
- 3-Bromo-4-methylpyridine
- Purity
- 96%
- Packaging
- 5g
- Price
- $77.7
- Updated
- 2023/06/20
TCI Chemical
- Product number
- B2831
- Product name
- 3-Bromo-4-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 1g
- Price
- $16
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B2831
- Product name
- 3-Bromo-4-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $33
- Updated
- 2025/07/31
TCI Chemical
- Product number
- B2831
- Product name
- 3-Bromo-4-methylpyridine
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $98
- Updated
- 2025/07/31
More
Less
3-Bromo-4-methylpyridine Chemical Properties,Usage,Production
Chemical Properties
Clear Liquid
Uses
An intermediate of pyridinyl pyrrole compounds as proton pump inhibitors with improved gastric acid secretion suppressive activity
Uses
3-Bromo-4-methylpyridine may be used as a building block in the preparation of:
- substituted 4-(2,2-diphenylethyl)pyridine-N-oxides for use as potent phosphodiesterase type 4 (PDE4) inhibitors
- benzodiazepine site ligands bearing tricyclic pyridone moiety for human GABAA receptor
- a novel isomer of ascididemin
- 3-bromopyridine-4-carbonitrile
Synthesis
108-89-4
3430-22-6
The general procedure for the synthesis of 4-methyl-3-bromopyridine from 4-methylpyridine was as follows: 0.054 mol of 4-methylpyridine was added to a 60 mL constant pressure dropping funnel. Under nitrogen protection and stirring conditions at room temperature, it was slowly added dropwise to a mixture consisting of 0.07 mol AlCl3 and 0.01 mol potassium bromide, and the reaction mixture was stirred for 1 hour. A condensing unit was installed, heated to 120°C, and 0.07 mol of bromine was added slowly dropwise for about 1 hour dropwise. Heating and stirring were continued at 120°C for 26 hours. Upon completion of the reaction, the reaction solution was cooled to room temperature and slowly poured into crushed ice with stirring. The pH was adjusted to neutral by the addition of sodium hydroxide solution and stirred until completely dissolved. The aqueous layer was extracted with dichloromethane, the organic layers were combined and the solvent was recovered by steam distillation. The resulting oily product was purified by column chromatography (eluent ratio of VP petroleum ether: ethyl acetate = 6:1) to give 5.3 g of 3-bromo-4-methylpyridine in the form of a tan oil with a purity of 99.9% and a yield of 57%.
References
[1] Patent: CN106243022, 2016, A. Location in patent: Paragraph 0067-0069
[2] Patent: WO2014/97150, 2014, A1. Location in patent: Page/Page column 22-23
[3] Patent: US2005/80085, 2005, A1. Location in patent: Page/Page column 12
[4] Patent: US5294610, 1994, A
3-Bromo-4-methylpyridine Preparation Products And Raw materials
Raw materials
Preparation Products
More
Less
3-Bromo-4-methylpyridine Suppliers
- Tel
- 021-58099652-8005 13585536065
- Fax
- 021-58099609
- bin.wu@shlschem.com
- Country
- China
- ProdList
- 9883
- Advantage
- 59
- Tel
- 4009004166/18616739031 18616739031
- 3007523370@qq.com
- Country
- China
- ProdList
- 52687
- Advantage
- 58
- Tel
- +86-024-83607930; 18640359690
- Fax
- 024-83607930
- sales@honghuchem.com
- Country
- China
- ProdList
- 256
- Advantage
- 58
- Tel
- 0418-5113999 18740177324
- Fax
- 2851606178
- sales@custchem.com.cn
- Country
- China
- ProdList
- 441
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 4006356688 18621169109
- Fax
- 86-21-61259102
- market03@meryer.com
- Country
- China
- ProdList
- 40228
- Advantage
- 62
- Tel
- 0418-6530555 2855550
- Fax
- +86-418-6502885
- Country
- China
- ProdList
- 338
- Advantage
- 69
- Tel
- 821-50328103-801 18930552037
- Fax
- 86-21-50328109
- 3bsc@sina.com
- Country
- China
- ProdList
- 15838
- Advantage
- 69
- Tel
- 400-0066400 13621662912
- Fax
- 021-55660885
- sales@jonln.com
- Country
- China
- ProdList
- 1995
- Advantage
- 65
- Tel
- 400-6106006
- Fax
- 021-67582001/03/05
- saleschina@alfa-asia.com
- Country
- China
- ProdList
- 30123
- Advantage
- 84
- Tel
- 021-67121386
- Fax
- 021-67121385
- Sales-CN@TCIchemicals.com
- Country
- China
- ProdList
- 24529
- Advantage
- 81
- Tel
- 021-021-58432009 400-005-6266
- Fax
- 021-58436166
- sales8178@energy-chemical.com
- Country
- China
- ProdList
- 44801
- Advantage
- 61
- Tel
- +86 (0) 571 85 58 67 18
- Fax
- 0086-571-85864795
- Country
- China
- ProdList
- 18207
- Advantage
- 66
- Tel
- 010-010-82967028 13522913783
- Fax
- +86-10-82967029
- 2355560935@qq.com
- Country
- China
- ProdList
- 12000
- Advantage
- 60
- Tel
- 13817811078
- Fax
- 86-021-50426522,50426273
- sales@jingyan-chemical.com
- Country
- China
- ProdList
- 9976
- Advantage
- 60
- Tel
- 0573-85285100 18627885956
- Fax
- 0573-85285100
- isenchem@163.com
- Country
- China
- ProdList
- 9310
- Advantage
- 66
- Tel
- 021-50795510 4000665055
- Fax
- 021-50795055
- sales@accelachem.com
- Country
- China
- ProdList
- 11035
- Advantage
- 64
- Tel
- 10-61256048 13810278579
- Fax
- +86 10 61256049
- sales@zeroschem.com
- Country
- China
- ProdList
- 1371
- Advantage
- 59
- Tel
- 021-54306202 13764082696
- info@hanhongsci.com
- Country
- China
- ProdList
- 42934
- Advantage
- 64
- Tel
- 010-59484199 18611897322
- sales@eternalchem.com
- Country
- China
- ProdList
- 4383
- Advantage
- 60
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 15527768836
- 1791901229@qq.com
- Country
- China
- ProdList
- 6950
- Advantage
- 52
- Tel
- 010-82954736 13391601435
- sales@isomersyn.com
- Country
- China
- ProdList
- 3295
- Advantage
- 57
- Tel
- +86(24) 31938773(O)
- Fax
- qq:174941352
- sales@co-chem.com
- Country
- China
- ProdList
- 225
- Advantage
- 62
- Tel
- 400 638 7771
- sales@heowns.com
- Country
- China
- ProdList
- 14435
- Advantage
- 57
- Tel
- 18270980682
- Fax
- 021 51613951
- mlcheng@sunwaypharm.cn
- Country
- China
- ProdList
- 8669
- Advantage
- 57
- Tel
- Please Send Email 18652950785
- Fax
- 025-87193546
- chemweiao@163.com
- Country
- China
- ProdList
- 4378
- Advantage
- 65
- Tel
- 0086-755-86198205
- acinfo@aemonchem.com
- Country
- China
- ProdList
- 1931
- Advantage
- 57
- Tel
- 021-56491756 13512199871
- Fax
- 021-5649-1756
- 2819742715@qq.com
- Country
- China
- ProdList
- 4000
- Advantage
- 55
- Tel
- 022-58013646 13011382049
- Fax
- 022-23854368
- sales@jinyudachem.com
- Country
- China
- ProdList
- 1930
- Advantage
- 55
- Tel
- 021-54824098, 021-37212705 021-37212706, 13391256916
- Fax
- 021-54824069
- sales@chemzq.com
- Country
- China
- ProdList
- 570
- Advantage
- 55
- Tel
- 022-60116533 13207668525
- Fax
- 022-60979672
- saleskc@scipharmacn.com
- Country
- China
- ProdList
- 603
- Advantage
- 58
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 0512-65617459 18915409046
- Fax
- 0512-65617459
- sales@sibian-chem.com
- Country
- China
- ProdList
- 1922
- Advantage
- 55
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 021-58170097
- info@topbiochem.com
- Country
- China
- ProdList
- 9510
- Advantage
- 58
- Tel
- 18652989687
- Fax
- +86-25-52131256
- sales@norris-pharm.com
- Country
- China
- ProdList
- 8878
- Advantage
- 55
- Tel
- 0371-86615086 18203638366 0371-86159066 13526786601
- Fax
- 0371-86159066
- Country
- China
- ProdList
- 2015
- Advantage
- 60
- Tel
- 4009209199
- Fax
- 86-021-52271987
- sales@9dingchem.com
- Country
- China
- ProdList
- 18209
- Advantage
- 56
- Tel
- 400-6206333 13167063860
- Fax
- 021-50323701
- anhua.mao@aladdin-e.com
- Country
- China
- ProdList
- 25003
- Advantage
- 65
- Tel
- 021-61552785
- Fax
- 021-55660885
- sales@shshiji.com
- Country
- China
- ProdList
- 9546
- Advantage
- 55
- Tel
- +86-18068513926
- Fax
- 0086-519-85153711
- Country
- China
- ProdList
- 1277
- Advantage
- 55
- Tel
- sales@witofly.com
- Country
- China
- ProdList
- 2864
- Advantage
- 52
- Tel
- 021-62960152
- Fax
- 021-52212593
- 934678158@qq.com
- Country
- China
- ProdList
- 9899
- Advantage
- 55
- Tel
- +86-021-50935922
- Fax
- +86-021-33847795
- Country
- China
- ProdList
- 7865
- Advantage
- 55
- Tel
- +86-28-85122536 85324413
- Fax
- +86-28-85326443
- market@astatech.cn
- Country
- China
- ProdList
- 8026
- Advantage
- 55
- Tel
- +86 0510-85629785
- Fax
- +86 0510-85625359
- Country
- China
- ProdList
- 2327
- Advantage
- 58
- Tel
- 0570-3066667
- Fax
- 0570-3063388
- Country
- China
- ProdList
- 3930
- Advantage
- 58
- Tel
- 0512-56316828 4008675858
- Fax
- +86-512-56316826
- sales@amateksci.com
- Country
- China
- ProdList
- 9874
- Advantage
- 55
- Tel
- 400-8706899
- Fax
- 400-8706899
- hysj_bj.com
- Country
- China
- ProdList
- 3583
- Advantage
- 55
More
Less
View Lastest Price from 3-Bromo-4-methylpyridine manufacturers
Shaanxi Dideu New Materials Co. Ltd
- Product
- 3-Bromo-4-methylpyridine 3430-22-6
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 10000KGS
- Release date
- 2025-05-30
Hebei Chuanghai Biotechnology Co., Ltd
- Product
- 3-Bromo-4-methylpyridine 3430-22-6
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-31
Henan Aochuang Chemical Co.,Ltd.
- Product
- 3-Bromo-4-methylpyridine 3430-22-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-27
3430-22-6, 3-Bromo-4-methylpyridineRelated Search:
2,6-Lutidine
Methyl acetate
Kresoxim-methyl
Methyl acrylate
Methylparaben
METSULFURON METHYL
4-Methylpyridine
3-Pyridyl bromide
Bensulfuron methyl
2-Chloro-5-chloromethylpyridine
2,4,6-Collidine
1-Hexadecylpyridinium bromide
Azamethiphos
Thiophanate-methyl
Methyl
Methyl bromide
3,5-Dibromo-4-methylpyridine
3-Bromo-4-cyanopyridine