2,6-DIAMINO-4-METHOXY PYRIMIDINE
- Product Name
- 2,6-DIAMINO-4-METHOXY PYRIMIDINE
- CAS No.
- 3270-97-1
- Chemical Name
- 2,6-DIAMINO-4-METHOXY PYRIMIDINE
- Synonyms
- Minoxidil Impurity 41;Minoxidil Impurity 13;2,4-Diamino-6-methoxypyrimidine;2,6-DIAMINO-4-METHOXY PYRIMIDINE;6-methoxy-pyrimidine-2,4-diamine;2,4-Pyrimidinediamine, 6-methoxy-;2-AMINO-6-METHOXYPYRIMIDIN-4-YLAMINE;2,6-Diamino-4-methoxy pyrimidine ,97%;2,4-Pyrimidinediamine, 6-methoxy- (9CI);2,6-DIAMINO-4-METHOXY PYRIMIDINE ISO 9001：2015 REACH
- CBNumber
- CB6344559
- Molecular Formula
- C5H8N4O
- Formula Weight
- 140.14
- MOL File
- 3270-97-1.mol
2,6-DIAMINO-4-METHOXY PYRIMIDINE Property
- Melting point:
- 162.0 to 166.0 °C
- Boiling point:
- 429.4±48.0 °C(Predicted)
- Density
- 1.341±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- form
- powder to crystal
- pka
- 5.24±0.10(Predicted)
- color
- White to Almost white
- λmax
- 265nm(MeOH)(lit.)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- D5088
- Product name
- 2,4-Diamino-6-methoxypyrimidine
- Purity
- >98.0%(HPLC)
- Packaging
- 1g
- Price
- $149
- Updated
- 2025/07/31
- Product number
- D5088
- Product name
- 2,4-Diamino-6-methoxypyrimidine
- Purity
- >98.0%(HPLC)
- Packaging
- 5g
- Price
- $445
- Updated
- 2025/07/31
- Product number
- Y4940
- Product name
- 2,6-Diamino-4-methoxypyrimidine
- Packaging
- 10g
- Price
- $523
- Updated
- 2021/12/16
- Product number
- FD147833
- Product name
- 2,6-Diamino-4-methoxypyrimidine
- Packaging
- 2g
- Price
- $523
- Updated
- 2021/12/16
- Product number
- JK102173
- Product name
- 2,6-Diamino-4-methoxypyrimidine
- Purity
- 97%
- Packaging
- 5g
- Price
- $656
- Updated
- 2021/12/16
2,6-DIAMINO-4-METHOXY PYRIMIDINE Chemical Properties,Usage,Production
Chemical Properties
Light yellow solid
Uses
2,4-Diamino-6-methoxypyrimidine is an organic amine compound used as a raw material for organic synthesis or as a pharmaceutical intermediate ingredient. The product can be used to prepare other heterocyclic compounds or anticancer active ingredients.
Synthesis
67-56-1
156-83-2
3270-97-1
General procedure for the synthesis of 2,4-diamino-6-methoxypyrimidine from methanol and 2,4-diamino-6-chloropyrimidine: 9.2 g (0.40 mol) of sodium metal was added to a flask containing 320 mL of methanol and stirred until completely dissolved. Subsequently, 28.9 g (0.20 mol) of 2,4-diamino-6-chloropyrimidine was added to this solution. The reaction mixture was placed under reflux conditions and stirred continuously for 44 hours. Upon completion of the reaction, the precipitated sodium chloride was removed by filtration. The filtrate was concentrated to dryness to give the crude product. The crude product was dissolved in 300 mL of ethanol, heated to boiling and then thermally filtered. The filtrate was allowed to stand overnight to crystallize 2,4-diamino-6-methoxypyrimidine. The product can be further purified by recrystallization of the mother liquor. After drying, 2,4-diamino-6-methoxypyrimidine (58.8 g, 84% yield) was obtained as a white solid. Melting point: 166-169 °C. 1H-NMR (300 MHz, d6-DMSO): δ= 3.18 (s, 3H, 6-OMe), 5.06 (s, 1H, 5-H), 5.94 (s, 2H, NH2), 6.05 (s, 2H, NH2). 13C-NMR (125 MHz, d6-DMSO): δ= 52.8 ( 6-OMe), 76.1 (5-C), 163.3 (2-C), 166.3 (4-C), 170.8 (6-C).
References
[1] Organic and Biomolecular Chemistry, 2010, vol. 8, # 10, p. 2397 - 2407
[2] Patent: US2015/209257, 2015, A1. Location in patent: Paragraph 0239; 0240; 0241; 0242; 0243
[3] Journal of Heterocyclic Chemistry, 1982, vol. 19, p. 917 - 921
2,6-DIAMINO-4-METHOXY PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,6-DIAMINO-4-METHOXY PYRIMIDINE manufacturers
- Product
- 2,6-DIAMINO-4-METHOXY PYRIMIDINE 3270-97-1
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-15
- Product
- 2,6-DIAMINO-4-METHOXY PYRIMIDINE 3270-97-1
- Price
- US $6.60/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 1kg -1000kg
- Release date
- 2020-01-02