ChemicalBook > CAS DataBase List > 2,5-Dimethoxybenzaldehyde

2,5-Dimethoxybenzaldehyde

Product Name
2,5-Dimethoxybenzaldehyde
CAS No.
93-02-7
Chemical Name
2,5-Dimethoxybenzaldehyde
Synonyms
Benzaldehyde, 2,5-dimethoxy-;34007;93-02--7;Benzaldehyde CRS;2,5-DiMethoxybenzaldehyde, 97% 25GR;NSC 6315;AKOS BBS-00003162;2,5-DimethoxybenzaL;2,5-Dimethoxybenzald;5-DiMethoxy benzaldehyde
CBNumber
CB6348890
Molecular Formula
C9H10O3
Formula Weight
166.17
MOL File
93-02-7.mol
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2,5-Dimethoxybenzaldehyde Property

Melting point:
46-48 °C (lit.)
Boiling point:
146 °C/10 mmHg (lit.)
Density 
1.1708 (rough estimate)
refractive index 
1.5260 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
795mg/l
form 
Crystalline Powder, Crystals and/or Chunks
color 
Yellow to beige
Water Solubility 
Soluble in chloroform and methanol. Slightly soluble in water.
Sensitive 
Air Sensitive
BRN 
509301
InChIKey
AFUKNJHPZAVHGQ-UHFFFAOYSA-N
LogP
1.910
CAS DataBase Reference
93-02-7(CAS DataBase Reference)
NIST Chemistry Reference
Benzaldehyde, 2,5-dimethoxy-(93-02-7)
EPA Substance Registry System
Benzaldehyde, 2,5-dimethoxy- (93-02-7)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38-43
Safety Statements 
26-36/37/39-24/25-36
WGK Germany 
2
RTECS 
CU5740500
Hazard Note 
Irritant
TSCA 
Yes
HS Code 
29124900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H334May cause allergy or asthma symptoms or breathing difficulties if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
D130605
Product name
2,5-Dimethoxybenzaldehyde
Purity
99%
Packaging
25g
Price
$54
Updated
2025/07/31
Sigma-Aldrich
Product number
D130605
Product name
2,5-Dimethoxybenzaldehyde
Purity
99%
Packaging
100g
Price
$115.9
Updated
2025/07/31
TCI Chemical
Product number
D1111
Product name
2,5-Dimethoxybenzaldehyde
Purity
>97.0%(GC)
Packaging
25g
Price
$57
Updated
2025/07/31
TCI Chemical
Product number
D1111
Product name
2,5-Dimethoxybenzaldehyde
Purity
>97.0%(GC)
Packaging
250g
Price
$389
Updated
2021/12/16
TRC
Product number
D460855
Product name
2,5-Dimethoxybenzaldehyde
Packaging
10g
Price
$65
Updated
2021/12/16
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2,5-Dimethoxybenzaldehyde Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline solid

Uses

2,5-Dimethoxybenzaldehyde is used in the preparation of 2,5-dimethoxyphenethylamine, which is utilized to prepare psychoactive drugs such as 2,5-dimethoxy-4-bromophenethylamine, 2,5-dimethoxy-4-iodophenethylamine and 4-Chloro-2,5-dimethoxy-phenethylamine. It acts as an intermediate in organic synthesis.

Application

2,5-Dimethoxybenzaldehyde, also known as 2C-H, is an organic compound and a benzaldehyde derivative. It can be used to produce 2,5-dimethoxyphenethylamine. 2C-H is also used to produce many other substituted phenethylamines such as 2C-B, 2C-I and 2C-C.

Definition

ChEBI: 2,5-dimethoxy-Benzaldehyde is a dimethoxybenzene.

Preparation

2,5-Dimethoxybenzaldehyde synthesis: Anethole is oxidized to anisaldehyde , which after isolation is subjected to a BaeyerVilliger oxidation reaction with performic or peracetic acid. The O-formyl-4-methoxyphenol obtained this way is hydrolyzed . 4-Methoxyphenol is subsequently formylated using the Reimer-Tiemann method and the obtained 2-hydroxy-5-methoxybenzaldehyde is methylated with dimethylsulfate to 2,5-dimethoxybenzaldehyde.

Synthesis

The synthesis of 2,5-dimethoxybenzaldehyde (2,5-DMBA) is mainly achieved through several well-established chemical methods, typically using readily available precursors as starting materials. A common industrial method is the formylation of 1,4-dimethoxybenzene (hydroquinone dimethyl ether), usually using the Vilsmeier-Haack reaction with reagents including N,N-dimethylformamide and phosphorus oxychloride; or using a Friedel-Crafts-type reaction, starting with 1,1-dichlorodimethyl ether, directly introducing the aldehyde group onto the activated aromatic ring. In addition, 2,5-DMBA can also be prepared by oxidizing the methyl group of 2,5-dimethoxytoluene, or through a multi-step reaction, starting with p-methoxyphenol, first undergoing a Reimer-Tiemann reaction to generate 2-hydroxy-5-methoxybenzaldehyde, and finally methoxylating it with dimethyl sulfate. These methods offer flexibility in terms of scale and precursor availability, making 2,5-DMBA a versatile intermediate for the synthesis of a wide range of fine chemicals, particularly psychoactive compounds such as 2C-H.

2,5-Dimethoxybenzaldehyde Preparation Products And Raw materials

Raw materials

Preparation Products

2,5-Dimethoxybenzylamine
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2,5-Dimethoxybenzaldehyde Suppliers

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View Lastest Price from 2,5-Dimethoxybenzaldehyde manufacturers

Shandong Vital Biotechnology Co., Ltd.
Product
2,5-Dimethoxybenzaldehyde 93-02-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100tons
Release date
2025-11-20
Shaanxi Dideu Medichem Co. Ltd
Product
2,5-Dimethoxybenzaldehyde 93-02-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200000KG
Release date
2025-09-12
RongNa Biotechnology Co.,Ltd
Product
2,5-Dimethoxybenzaldehyde 93-02-7
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
20 tons
Release date
2025-05-04

93-02-7, 2,5-DimethoxybenzaldehydeRelated Search:

1,1-Dimethoxyethane Benzaldehyde p-Anisaldehyde o-Anisaldehyde 3-(METHOXYMETHOXY)BENZALDEHYDE 4-Dimethylaminobenzaldehyde 3-Methoxybenzaldehyde Diphenyldimethoxysilane Dimethoxymethane 2,4-Dimethoxybenzaldehyde 2',5'-Dimethoxyacetophenone 2,5-DIMETHOXYBENZOYL CHLORIDE 2,4,5-Trimethoxybenzoic acid Veratraldehyde 2,3-DIMETHOXYBENZALDEHYDE 2,6-Dimethoxybenzaldehyde KHELLIN 3,5-Dimethoxybenzaldehyde ,98%

  • 2,5-Dimethoxybenzaldehyde,97%
  • 2,5-Dimethoxybenzald
  • 5-DiMethoxy benzaldehyde
  • 2,5-DiMethoxybenzaldehyde, 97% 25GR
  • NSC 6315
  • 93-02--7
  • 2,5-Dimethoxybenzaldehyde Vetec(TM) reagent grade, 98%
  • 2,5-DIMETHOXYBENZALDEHYDE
  • AKOS BBS-00003162
  • Benzaldehyde, 2,5-dimethoxy-
  • 2,5-Dimethoxybenzaldehyde, 98+%
  • 34007
  • 2,5-dimethoxy-benzaldehyd
  • Benzaldehyde CRS
  • 2,5-Dimethoxybenzaldehyde &gt
  • 2,5-DimethoxybenzaL
  • Methoxamine Impurity 2 (2,5-Dimethoxybenzaldehyde)
  • Supply 2,5-Dimethoxybenzaldehyde
  • 2,5 -Dimethoxybenzaldehyde 2
  • gentisic aldehyde dimethyl ether
  • CAS 93-02-7 2, 5-Dimethoxybenzaldehyde 2, 5- (MeO) 2phcho
  • 2,5-Dimethoxybenzaldehyde (2,5-DMB) pure, 98%
  • 93-02-7
  • 1993-02-7
  • 1993-2-7
  • 1993-02-07
  • 92-02-7
  • ALDEHYDE
  • Organic Building Blocks
  • Aldehydes
  • C9
  • Carbonyl Compounds
  • Building Blocks
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks
  • Aromatics
  • FINE Chemical & INTERMEDIATES
  • BUILDING BLOCKS
  • Benzaldehyde
  • Adehydes, Acetals & Ketones
  • Anisoles, Alkyloxy Compounds & Phenylacetates
  • Aldehydes
  • C9
  • Carbonyl Compounds
  • 93-02-7