ChemicalBook > CAS DataBase List > 4-HYDROXY-6-METHYLQUINAZOLINE

4-HYDROXY-6-METHYLQUINAZOLINE

Product Name
4-HYDROXY-6-METHYLQUINAZOLINE
CAS No.
19181-53-4
Chemical Name
4-HYDROXY-6-METHYLQUINAZOLINE
Synonyms
BUTTPARK 51\07-11;6-methylquinazolin-4-ol;6-methyl-4-quinazolinol;6-methyl-4-quinazolinone;6-Methyl-4(3H)-quinazolinone;6-methyl-1H-quinazolin-4-one;6-methyl-3H-quinazolin-4-one;4-HYDROXY-6-METHYLQUINAZOLINE;4(3H)-Quinazolinone, 6-methyl-;6-Methylquinazolin-4(3H)-one98%
CBNumber
CB6360108
Molecular Formula
C9H8N2O
Formula Weight
160.17
MOL File
19181-53-4.mol
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4-HYDROXY-6-METHYLQUINAZOLINE Property

Melting point:
238-240
Boiling point:
334.6±35.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
2.06±0.20(Predicted)
Appearance
White to off-white Solid
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Safety

Hazard Codes 
Xi
Hazard Note 
Irritant
HS Code 
2933399990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
M356168
Product name
6-methylquinazolin-4-ol
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
M356168
Product name
6-methylquinazolin-4-ol
Packaging
50mg
Price
$60
Updated
2021/12/16
SynQuest Laboratories
Product number
4H17-1-67
Product name
6-Methylquinazolin-4(3H)-one
Purity
98%
Packaging
1g
Price
$64
Updated
2021/12/16
AK Scientific
Product number
Z4348
Product name
6-Methylquinazolin-4-ol
Packaging
250mg
Price
$72
Updated
2021/12/16
Apolloscientific
Product number
OR2839
Product name
4-Hydroxy-6-methylquinazoline
Purity
97%
Packaging
250mg
Price
$22
Updated
2021/12/16
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4-HYDROXY-6-METHYLQUINAZOLINE Chemical Properties,Usage,Production

Synthesis

40545-33-3

149-73-5

19181-53-4

Concentrated hydrochloric acid (4.16 mL, 49.9 mmol) was slowly added to a mixed solution containing commercially available 2-amino-5-methylbenzamide (5.00 g, 33.3 mmol) and trimethyl orthoformate (51.0 mL, 466 mmol) at 0 °C. The reaction mixture was stirred continuously for 2 hours at room temperature. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue obtained was diluted with distilled water and neutralized with 2 M aqueous sodium hydroxide solution to neutral. Subsequently, the precipitated solid product was collected by filtration and washed sequentially with distilled water, methanol, and ether to finally obtain 6-methyl-4-hydroxyquinazoline (15) as a white powdery solid (4.33 g, 81% yield). The structure of the product was confirmed by 1H NMR (300 MHz, DMSO-d6): δ 2.44 (3H, s), 7.57 (1H, d, J = 8.4 Hz), 7.62-7.66 (1H, m), 7.91-7.93 (1H, m), 8.03 (1H, s), 12.2 (1H, bs).

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 19, p. 5487 - 5505
[2] Bioorganic and Medicinal Chemistry Letters, 2001, vol. 11, # 4, p. 545 - 548
[3] Bioorganic and Medicinal Chemistry, 2003, vol. 11, # 3, p. 383 - 391

4-HYDROXY-6-METHYLQUINAZOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-HYDROXY-6-METHYLQUINAZOLINE manufacturers

Career Henan Chemical Co
Product
4-HYDROXY-6-METHYLQUINAZOLINE 19181-53-4
Price
US $3.00/KG
Min. Order
1KG
Purity
90%-99.9%
Supply Ability
1000kg
Release date
2019-07-04

19181-53-4, 4-HYDROXY-6-METHYLQUINAZOLINERelated Search:

Nolatrexed dihydrochloride 2,6-DIMETHYLQUINAZOLIN-4(3H)-ONE 4-HYDROXY-6-METHYLQUINAZOLINE 2-AMINO-6-METHYL-4(3H)-QUINAZOLONE Raltitrexed 8-METHYL-4-QUINAZOLONE 4-Hydroxy-2-methylquinazoline 8-Chloro-2-methylquinazolin-4(3H)-one NU1025 6-Quinazolinecarboxylic acid, 3,4-dihydro-3-(2-chlorophenyl)-5,7-dimet hyl-2-((((methylamino)carbonyl)oxy)methyl)-4-oxo-, ethyl ester (6-METHYL-4-OXO-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID Doqualast 3-(2,4-DICHLORO-5-METHOXYPHENYL)-6-METHYL-2-SULFANYL-4(3H)-QUINAZOLINONE (3-ETHYL-6-METHYL-4-OXO-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID 3-amino-2-(4-chlorophenyl)-6-methyl-4(3H)-quinazolinone (3-ALLYL-6-METHYL-4-OXO-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID 3-(4-FLUOROPHENYL)-2,6-DIMETHYL-4(3H)-QUINAZOLINONE (6-METHYL-4-OXO-3-PHENYL-3,4-DIHYDRO-QUINAZOLIN-2-YLSULFANYL)-ACETIC ACID

  • 4-HYDROXY-6-METHYLQUINAZOLINE
  • BUTTPARK 51\07-11
  • 3,4-Dihydro-6-methyl-4-oxoquinazoline
  • 3,4-Dihydro-6-methyl-4-oxoquinazoline 98%
  • 4-Hydroxy-6-methylquinazoline 97%
  • 4-Hydroxy-6-methylquinazoline97%
  • 6-methyl-4-quinazolinone
  • 6-methylquinazolin-4-ol
  • 6-Methylquinazolin-4(3H)-one 98%
  • 6-Methyl-4(3H)-quinazolinone
  • 6-Methylquinazolin-4-ol, 6-Methylquinazolin-4(3H)-one
  • 6-Methylquinazolin-4(3H)-one98%
  • 6-methyl-1H-quinazolin-4-one
  • 4(3H)-Quinazolinone, 6-methyl-
  • 4-HYDROXY-6-METHYLQUINAZOLINE ISO 9001：2015 REACH
  • 6-methyl-3H-quinazolin-4-one
  • 6-methyl-4-quinazolinol
  • 19181-53-4
  • blocks
  • Heterocycles
  • Quinolines