4-Trifluoromethylphenol

Preparation method Chemical Characteristics Uses

Product Name: 4-Trifluoromethylphenol
CAS No.: 402-45-9
Chemical Name: 4-Trifluoromethylphenol
Synonyms: 4-(TRIFLUOROMETHYL)PHENOL;TFMPO;P-Trifluoromethyl;TRIFLUORO-PARA-CRESOL;Fluoxetine Impurity 4;4-HYDROXYBENZOTRIFLUORI;4-trifluorotoluolphenol;p-TrifluoroMethylphenyl;Fluoxetine EP Impurity D;α,α,α-Trifluoro-p-cresol
CBNumber: CB6371577
Molecular Formula: C7H5F3O
Formula Weight: 162.11
MOL File: 402-45-9.mol

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4-Trifluoromethylphenol Property

Melting point:: 45-47 °C(lit.)
Boiling point:: 71.5-72 °C (8 mmHg)
Density: 1.3226 (estimate)
Flash point:: 183 °F
storage temp.: Store at <= 20°C.
Water Solubility: Insoluble in water
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form: Crystals
pka: pK1:8.675 (25°C)
color: White to yellow-brown
BRN: 1637019
Stability:: Light Sensitive
InChIKey: BAYGVMXZJBFEMB-UHFFFAOYSA-N
CAS DataBase Reference: 402-45-9(CAS DataBase Reference)
NIST Chemistry Reference: p-Hydroxybenzotrifluoride(402-45-9)
EPA Substance Registry System: 4-(Trifluoromethyl)phenol (402-45-9)

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Safety

Hazard Codes: Xn,Xi
Risk Statements: 22-37/38-41-36/37/38
Safety Statements: 26-39-24/25
RIDADR: UN 2926 4.1/PG 2
WGK Germany: 3
Hazard Note: Irritant/Keep Cold
PackingGroup: Ⅱ
HS Code: 29081000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H228Flammable solid

H301Toxic if swalloed

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P240Ground/bond container and receiving equipment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 8.41244
Product name: 4-Hydroxybenzotrifluoride
Purity: for synthesis
Packaging: 1g
Price: $53.1
Updated: 2024/03/01

Sigma-Aldrich

Product number: 178470
Product name: 4-(Trifluoromethyl)phenol
Purity: 97%
Packaging: 1g
Price: $54.8
Updated: 2024/03/01

Sigma-Aldrich

Product number: 8.41244
Product name: 4-Hydroxybenzotrifluoride
Purity: for synthesis
Packaging: 5G
Price: $215
Updated: 2024/03/01

Sigma-Aldrich

Product number: 178470
Product name: 4-(Trifluoromethyl)phenol
Purity: 97%
Packaging: 5g
Price: $124
Updated: 2024/03/01

TCI Chemical

Product number: H0644
Product name: 4-Hydroxybenzotrifluoride
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $79
Updated: 2024/03/01

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4-Trifluoromethylphenol Chemical Properties,Usage,Production

Preparation method

Chlorosilane and bromotrifluoromethane at-59℃form trifluoromethylsilane. Trifluoromethylsilane and benzoquinone in the presence of catalyst form 4-triethylsiloxy-4-trifluoromethyl-2,5-cyclohexadien-1-ketone which is reduced by zinc powder to p-trifluoromethylphenol with a yield of 71%. This method avoids the use of hydrofluoric acid in the traditional process but should be carried out under anhydrous conditions.If there were water trifluoromethyl silane would rapidly become silanol under the effect of water and alkali. The catalyst used in the reaction is alkali of which the strength has nothing to do with the catalytic activity. By now the role of catalyst is still unknown but the reaction can not proceed without catalyst.

Chemical Characteristics

Off-white crystal

Uses

For intermediate of medicine and pesticide.

Chemical Properties

White to yellowish-brown crystals

Uses

4-(Trifluoromethyl)phenol (4-hydroxybenzotrifluoride) was used in the synthesis of diaryl ether.

Uses

Intermediates of Liquid Crystals

Definition

ChEBI: 4-(trifluoromethyl)phenol is a member of the class of (trifluoromethyl)benzenes that is p-cresol in which the methyl group is perfluorinated. It is a metabolite of the drug fluoxetine. It has a role as a marine xenobiotic metabolite and a drug metabolite. It is a member of phenols and a member of (trifluoromethyl)benzenes. It is functionally related to a (trifluoromethyl)benzene and a p-cresol.

Synthesis Reference(s)

The Journal of Organic Chemistry, 54, p. 2873, 1989 DOI: 10.1021/jo00273a020

General Description

4-(Trifluoromethyl)phenol molecule, bound at the active site of H61T (His-61→Thr) mutant, shows strong density.

4-Trifluoromethylphenol Preparation Products And Raw materials

Raw materials

Preparation Products

4-(TRIFLUOROMETHYL)PHENOXYACETIC ACID

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4-Trifluoromethylphenol Suppliers

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View Lastest Price from 4-Trifluoromethylphenol manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 4-Trifluoromethylphenol 402-45-9
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2024-11-09

Hebei Kingfiner Technology Development Co.Ltd

Product: 4-Trifluoromethylphenol 402-45-9
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 50000kg
Release date: 2024-06-24

Honest Joy Holdings Limited

Product: 4-(Trifluoromethyl)phenol 402-45-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99.4%
Supply Ability: 100 tons
Release date: 2022-02-20

402-45-9, 4-TrifluoromethylphenolRelated Search:

4-Trifluoromethylphenylboronic acid p-Cresol alpha,alpha,alpha-Trifluoro-o-toluoyl chloride 2-(Trifluoromethyl)benzoic acid Diethylstilbestrol Xylenol o-Cresol 4-(Trifluoromethyl)cinnamic acid 4-(Trifluoromethyl)benzene-1-sulfonyl chloride Trifluoromethanesulfonic acid Cresol 4'-(Trifluoromethyl)acetophenone 3-Chloro-4-hydroxybenzotrifluoride Trifluoro-p-tolunitrile 3-Trifluoromethylphenol p-Trifluoromethoxy phenol 3-(Trifluoromethyl)benzaldehyde 4-Fluorophenol

Fluoxetine EP Impurity D

alpha,alpha,alpha-Trifluoro-p-cresol,loosecrystals

Phenol, 4-(trifluoromethyl)-

P-HYDROXYBENZOTRIFLUORIDE

P-(TRIFLUOROMETHYL)PHENOL

ALPHA,ALPHA,ALPHA-TRIFLUORO-4-CRESOL

ALPHA,ALPHA,ALPHA-TRIFLUORO-P-CRESOL

4-(TRIFLUOROMETHYL)PHENOL

4-HYDROXYBENZOTRIFLUORIDE

4-HYDROXY-ALPHA,ALPHA,ALPHA-TRIFLUOROTOLUENE

4-Hydroxy-α,α,α-trifluorotoluene

α,α,α-Trifluoro-p-cresol

4-Hydroxybenxotrifluoride

ALPHA,ALPHA,ALPHA-TRIFLUORO-P-CRESOL, 99 %

4-HydroxytrifluoromethylBenzene

Fluoxetine Hydrochloride Impurity Ⅱ：4-Trifluoromethylphenol

4-Hydroxybenzotrifluoride,98%

4-Hydroxybenzotrifluoride99%

4-Hydroxybenzotrifluoride 99%

TRIFLUORO-PARA-CRESOL

4/p-Trifluoromethylaniline

P-Trifluoromethyl

α,α,α-Trifluoro-p-cresol, 4-Hydroxybenzotrifluoride

TFMPO

alpha,alpha,alpha-Trifluoro-p-cresol,98%

4-HYDROXYBENZOTRIFLUORI

4-(Trifluoromethyl)phenol ,98%

4-trifluorotoluolphenol

alpha,alpha,alpha-Trifluoro-p-cresol, 98% 1GR

alpha,alpha,alpha-Trifluoro-p-cresol, 98% 5GR

4-Hydroxy-alpha,alpha,alpha-trifluorotoluene alpha,alpha,alpha-Trifluoro-p-cresol 4-(Trifluoromethyl)phenol

p-TrifluoroMethylphenyl

4-(TrifluoroMethyl)phenol 97%

4-(TrifluoroMethyl)phenol, 97+%

α,α,α-Trifluoro-p-cresol 4-Hydroxybenzotrifluoride 4-Hydroxy-α,α,α-trifluorotoluene p-Hydroxybenzotrifluoride p-Trifluoromethylphenol

4-Hydroxybenzotrifluoride for synthesis

Fluoxetine Impurity 4

Fluoxetine Impurity 4(EP-D)

4-Hydroxybenzotrifluoride&gt

4-Hydroxybenzotrifluoride (alpha-Trifluoro p-Cresol

Fluoxetine Hydrochloride Impurity Ⅱ：4-Trifluoromethylphenol

?,?,?-trifluoro-p-cresol

Fluoxetine Impurity 4(Fluoxetine EP Impurity D)

402-45-9

402-56-9

C7H5F3O

Building Blocks

Oxygen Compounds

Phenols

Organic Building Blocks

Fluorochemicals

Trifluoromethylbenzene serise

Aromatic Phenols

Phenol&Thiophenol&Mercaptan

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