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5-Bromouracil

Product Name
5-Bromouracil
CAS No.
51-20-7
Chemical Name
5-Bromouracil
Synonyms
5-bromopyrimidine-2,4(1H,3H)-dione;5-BROMOPYRIMIDINE-2,4-DIOL;5-BROMO-1H-PYRIMIDINE-2,4-DIONE;5-Bromo-1,2,3,4-tetrahydropyrimidine-2,4-dione;5-BrUra;BROMOURACIL;5-Bromuracil;5-BROMOURACIL;5-bromo-uraci;BROMOURACIL, 5-
CBNumber
CB6388195
Molecular Formula
C4H3BrN2O2
Formula Weight
190.98
MOL File
51-20-7.mol
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5-Bromouracil Property

Melting point:
>300 °C (lit.)
Density 
1.8710 (rough estimate)
refractive index 
1.6200 (estimate)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
<1g/l
form 
Solid
pka
6.77±0.10(Predicted)
color 
White
Water Solubility 
SOLUBLE IN COLD WATER
Merck 
14,1445
BRN 
127176
InChIKey
LQLQRFGHAALLLE-UHFFFAOYSA-N
CAS DataBase Reference
51-20-7(CAS DataBase Reference)
NIST Chemistry Reference
5-Bromouracil(51-20-7)
EPA Substance Registry System
5-Bromouracil (51-20-7)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-46
Safety Statements 
36/37-53-45-24/25
WGK Germany 
3
RTECS 
YQ9060000
TSCA 
Yes
HS Code 
29335995
Hazardous Substances Data
51-20-7(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
852473
Product name
5-Bromouracil
Purity
98%
Packaging
5g
Price
$45.3
Updated
2024/03/01
Sigma-Aldrich
Product number
852473
Product name
5-Bromouracil
Purity
98%
Packaging
25g
Price
$85.1
Updated
2024/03/01
TCI Chemical
Product number
B0665
Product name
5-Bromouracil
Purity
>98.0%(T)
Packaging
25g
Price
$120
Updated
2024/03/01
Alfa Aesar
Product number
A14799
Product name
5-Bromouracil, 98+%
Packaging
5g
Price
$19.65
Updated
2024/03/01
Alfa Aesar
Product number
A14799
Product name
5-Bromouracil, 98+%
Packaging
25g
Price
$56.65
Updated
2024/03/01
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5-Bromouracil Chemical Properties,Usage,Production

Description

5-bromouracil (5-BU) is a uracil derivative, and its 5' position of the pyrimidine ring is halogenated. If 5-BU is incorporated into DNA in place of thymine, the tautomeric shift will occur, and the 5-BU will base pair with guanine. After the replication, an A-T to G-C transition occurs. Furthermore, the presence of 5-BU within DNA increases the sensitivity of the molecule to UV light. 5-BU is structurally similar to thymine. Therefore, it is considered a thymine analog and base-pairs normally with adenine. It is rarely present in its enol form, where its base pairs with guanine. 5-Bromouracil treats neoplasms in the form of its nucleoside, 5-bromo-2-deoxy-uridine[1-2].

Chemical Properties

Prisms from H 2 O.

Uses

A major chemical mutagen. Incorporates into DNA, altering base-pair sequencing by replacing thymine

Definition

ChEBI: A pyrimidine having keto groups at the 2- and 4-positions and a bromo group at the 5-position.

General Description

White powder.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

A halogenated amide. Organic amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx).

Hazard

Moderately toxic, alters DNA by replacing thymine.

Health Hazard

ACUTE/CHRONIC HAZARDS: When heated to decomposition 5-Bromouracil emits very toxic fumes of bromide ion and NOx.

Fire Hazard

Flash point data for 5-Bromouracil are not available, but 5-Bromouracil is probably combustible.

Safety Profile

Moderately toxic by intraperitoneal route. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of Brand NOx.

References

[1] Bhagavan, N. and C. Ha. “Chapter 21 – Structure and Properties of DNA.” (2015): 381-400.
[2] Shen, Chang-Hui. “Nucleic Acid-Based Cellular Activities.” Diagnostic Molecular Biology 25 1 (2019): 27-57.

5-Bromouracil Preparation Products And Raw materials

Raw materials

Preparation Products

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5-Bromouracil Suppliers

ELION INTERNATIONAL(HONGKONG) CO., LTD
Tel
177-6725-7858 15967138206
Fax
0571-85022751
Email
sales@hzbrown.com
Country
China
ProdList
72
Advantage
62
Shanghai He Huan Chemical Co., Ltd.
Tel
021-60345187 13917602471
Fax
021-60345187
Email
lzz841106@aliyun.com
Country
China
ProdList
9908
Advantage
58
Wuhan Hongde Yuexin Pharmatech Co.,Ltd
Tel
027-83855393 15071227934
Fax
027-83855393
Email
3306264753@qq.com
Country
China
ProdList
1865
Advantage
58
Shanghai Finechem Biotechnology Co., Ltd.
Tel
15821337685
Email
hwh-chem@163.com
Country
China
ProdList
96
Advantage
58
FUXIN QINGJISHENG SCIENCE AND TECHNOLOGY CO.,LID
Tel
13365798276
Email
hxy696128@126.com
Country
China
ProdList
154
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Tel
021-50182298 021-50180596
Fax
+86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2210
Advantage
55
SiChuang NanBu Honesty Technology Co., Ltd.
Tel
0838-5675166 15883665058
Fax
0838-5675535
Email
nbcxkj@126.com
Country
China
ProdList
668
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006608290; 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40241
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3576
Advantage
66
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View Lastest Price from 5-Bromouracil manufacturers

Chongqing Zhihe Biopharmaceutical Co., Ltd.
Product
5-Bromouracil 51-20-7
Price
US $0.00-0.00/kg
Min. Order
0.10000000149011612kg
Purity
99
Supply Ability
20tons
Release date
2024-02-06
WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Product
5-Bromouracil 51-20-7
Price
US $0.00/KG
Min. Order
100g
Purity
98%+
Supply Ability
100kg
Release date
2021-05-14
WUHAN FORTUNA CHEMICAL CO., LTD
Product
5-Bromouracil 51-20-7
Price
US $0.00/KG
Min. Order
1KG
Purity
≥98.0%
Supply Ability
100kg/month
Release date
2021-09-28

51-20-7, 5-BromouracilRelated Search:


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  • 51-20-7
  • C4H3N2O2Br
  • AMINE
  • Heterocyclic Building Blocks
  • Halogenated Heterocycles
  • Pyrimidines
  • Nucleoside Analogs
  • Nucleosides, Nucleotides, Oligonucleotides
  • Building Blocks
  • Biochemicals and Reagents
  • BioChemical
  • Detergents
  • Biochemistry
  • Nucleobases and their analogs
  • Nucleosides, Nucleotides & Related Reagents
  • Nucleic acids
  • Bases & Related Reagents
  • Mutagenesis Research Chemicals
  • Nucleotides
  • Pyrimidine series