Description References
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L-Cystine

Description References
Product Name
L-Cystine
CAS No.
56-89-3
Chemical Name
L-Cystine
Synonyms
(H-CYS-OH)2;(CYS)2;l-cystin;-Cystine;1-cystine;Cystine CRS;Cystine acid;L-(-)-CYSTINE;L-CYSTINE BASE;(r-(r*,r*))-3,3’-dithiobis(2-aminopropanoicacid)
CBNumber
CB6394079
Molecular Formula
C6H12N2O4S2
Formula Weight
240.3
MOL File
56-89-3.mol
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L-Cystine Property

Melting point:
>240 °C (dec.) (lit.)
alpha 
-224 º(c=2 in 1M HCl)
Boiling point:
468.2±45.0 °C(Predicted)
Density 
1.68
refractive index 
-222.5 ° (C=1, 1mol/L HCl)
storage temp. 
2-8°C
solubility 
1 M HCl: 100 mg/mL
form 
Powder/Solid
pka
1.0, 2.1, 8.02, 8.71(at 25℃)
color 
White
PH
4.60
optical activity
[α]20/D 219±5°, c = 1% in 1 M HCl
Water Solubility 
0.112 g/L (25 ºC)
Merck 
14,2782
BRN 
1728094
Stability:
Stable. Incompatible with strong oxidizing agents.
InChIKey
LEVWYRKDKASIDU-IMJSIDKUSA-N
LogP
0.773 (est)
CAS DataBase Reference
56-89-3(CAS DataBase Reference)
NIST Chemistry Reference
L-Cystine(56-89-3)
EPA Substance Registry System
L-Cystine (56-89-3)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-22
Safety Statements 
26-36-24/25
RIDADR 
2811
WGK Germany 
3
RTECS 
HA2690000
Hazard Note 
Irritant
TSCA 
Yes
PackingGroup 
III
HS Code 
29309014
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SAB1305544
Product name
MONOCLONAL ANTI-NEPHRIN antibody produced in mouse
Purity
clone 174CT2.1.1, crude ascites, buffered aqueous solution
Packaging
100μL
Price
$466
Updated
2024/03/01
Sigma-Aldrich
Product number
30200
Product name
L-Cystine
Purity
≥99.7% (TLC)
Packaging
25g
Price
$43.4
Updated
2024/03/01
Sigma-Aldrich
Product number
2470
Product name
L-Cystine - CAS 56-89-3 - Calbiochem
Packaging
25G
Price
$77.4
Updated
2024/03/01
Sigma-Aldrich
Product number
1161586
Product name
Cystine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$519
Updated
2024/03/01
Sigma-Aldrich
Product number
1.02836
Product name
L-Cystine
Purity
suitable for biopharmaceutical production FCC
Packaging
1kg
Price
$305
Updated
2024/03/01
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L-Cystine Chemical Properties,Usage,Production

Description

L-cystine (formula: (SCH2CH(NH2) CO2H)2), the L-form of cystine) is a covalently linked dimeric nonessential amino acid formed through the oxidation of cysteine. It is contained in many foods including eggs, meat, dairy products, and whole grains as well as in skin and hairs. L-cystine and L-methionine are the amino-acids required for wound healing and formation of epithelial tissue. It is able to stimulate the hematopoietic system and promote the formation of white and red blood cells. It can also be used as a component of parental and enteral nutrition. It can also be used for the treatment of dermatitis and protection of liver function. L-cystine is manufactured through the enzymatic conversion from DL-amino thiazoline carboxylic acid.

References

http://www.ajiaminoscience.com/products/manufactured_products/l-amino_acids/L-Cystine.aspx
https://pubchem.ncbi.nlm.nih.gov/compound/L-cystine#section=Pharmacology
https://en.wikipedia.org/wiki/Cystine

Chemical Properties

A white or almost white, crystalline powder, practically insoluble in water and in alcohol.

Uses

L-Cystine is used as an antioxidant, protecting tissues against radiation and pollution. It finds application in protein synthesis. It is required for utilization of vitamin B6 and is useful in healing burns and wounds. It is also is required by certain malignant cell lines in the culture medium as well as for the growth of certain micro-organisms. It is useful in the stimulation of hematopoietic system and promotes the formation of white and red blood cells. It is an active ingredient in medications used to treat dermatitis.

Uses

L-Cystine has been used in in vitro cystine solubility assay to identify potential drugs that influence cystine solubility. It is also used as a supplement of phosphate-buffered saline to slice and wash periprosthetic tissues.

Uses

L-Cystine is a non-essential amino acid for human development. L-Cystine is formed by the dimerization of two cysteines through the sulfur.

Definition

ChEBI: L-cystine is the L-enantiomer of the sulfur-containing amino acid cystine. It has a role as a flour treatment agent, a human metabolite, a Saccharomyces cerevisiae metabolite, a mouse metabolite and an EC 1.2.1.11 (aspartate-semialdehyde dehydrogenase) inhibitor. It is a cystine, a L-cysteine derivative and a non-proteinogenic L-alpha-amino acid. It is a conjugate acid of a L-cystine anion. It is an enantiomer of a D-cystine. It is a tautomer of a L-cystine zwitterion.

General Description

This Standard Reference Material (SRM) is intended primarily for use in validating microchemical procedures for the determination of carbon, hydrogen, nitrogen, and sulfur in organic matter. SRM 143d is pure crystalline cystine supplied in a 2 g unit size. For more information, please refer to the SDS and COA.

SRM 143D_cert SRM 143D _SDS

Biochem/physiol Actions

Cysteine is the source of disulfide linkages in proteins and has a role in sulfur transport. It undergoes rapid oxidation to form cystine at physiological pH. L-cystine is crucial for oxygen production and low density lipoprotein modification by arterial smooth muscle cells. It also has a role in the synthesis of glutathione.

Safety Profile

Low toxicity by ingestion. When heated to decomposition it emits toxic fumes of PO, and SOx

Purification Methods

Cystine disulfoxide impurity is removed by treating an aqueous suspension with H2S. The cystine is filtered off, washed with distilled water and dried at 100o under a vacuum over P2O5. Crystallise it by dissolving in 1.5M HCl, then adjusting to neutral pH with ammonia. Likely impurities are D-cystine, meso-cystine and tyrosine. Also purify it by dissolving it in 10% NH3 and adding gradually dilute AcOH until the point of precipitation and cooling slowly [Dughton & Harrison Acta Cryst 12 396, 402 1959.] Alternatively dissolve it in 6N NH4OH and evaporate it at room temperature for crystallisation to occur. [Chaney & Steinrauf Acta Cryst 30 711 1974, Beilstein 4 IV 3155.]

L-Cystine Preparation Products And Raw materials

Raw materials

KERATIN Boc-D-Tyr-OH Α-protein terylene Hydrolyzate L-Histidine DL-Serine Hydrochloric acid SILK Sodium hydroxide Industrial ammonia Activated carbon,decolor L(+)-Arginine Activated carbon N-CARBOBENZOXY-DL-LEUCINE Ethylenediaminetetraacetic acid

Preparation Products

Cilastatin DL-Cystine L-Cysteine monohydrochloride L-Cysteine L-Cysteine hydrochloride monohydrate
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View Lastest Price from L-Cystine manufacturers

Hebei Andu Technology Com.,Ltd
Product
L-Cystine 56-89-3
Price
US $3.50/kg
Min. Order
1kg
Purity
≥99%
Supply Ability
3000tons/month
Release date
2024-08-17
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
L-Cystine 56-89-3
Price
US $999.00-800.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000
Release date
2024-08-22
Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
L-Cystine 56-89-3
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-16

56-89-3, L-CystineRelated Search:

Dilauryl thiodipropionate Cyproterone acetate Tris(hydroxymethyl)aminomethane DL-Homocysteine L-Cysteine ALTRENOGEST β-Alanine Ethyl 2-(Chlorosulfonyl)acetate N-Acetyl-L-cysteine 6-Aminocaproic acid Citric acid Glycine Folic acid ACETYL-L-CYSTINE L-Cysteine monohydrochloride Ascoric Acid L-Tryptophan L-Leucine

  • (r-(r*,r*))-3,3’-dithiobis(2-aminopropanoicacid)
  • 1-cystine
  • 3,3’-dithiobis(2-amino-,(r-(r*,r*))-propanoicaci
  • 3,3’-dithiobis(2-aminopropanoicacid)
  • 3,3’-dithiobis-l-alanin
  • 3,3'-Dithiobis(2-aminopropanoic acid)
  • 3,3'-Dithiodialanine
  • Alanine, 3,3'-dithiobis-
  • Alanine, 3,3'-dithiodi-
  • alpha-Diamino-beta-dithiolactic acid
  • beta,beta’-diamino-beta,beta’-dicarboxydiethyldisulfide
  • Carbocysteine Impurity 3
  • L-Cystine in stock GMP Factory
  • Acetylcysteine Impurity 1（Acetylcysteine EP Impurity A）
  • Acetylcysteine Impurity A
  • beta,beta’-dithiodialanine
  • beta,beta'-Diamino-beta,beta'-dicarboxydiethyl disulfide
  • beta,beta'-Dithiobisalanine
  • beta,beta'-Dithiodialanine
  • Bis(beta-amino-beta-carboxyethyl) disulfide
  • bis(beta-amino-beta-carboxyethyl)disulfide
  • Cysteine disulfide
  • cysteinedisulfide
  • Cystin
  • Cystine acid
  • cystineacid
  • Dicysteine
  • Gelucystine (L form)
  • L-3,3’-Dithiodialanine
  • Nephrin
  • Oxidized L-cysteine
  • oxidizedl-cysteine
  • Propanoic acid, 3,3'-dithiobis(2-amino-, (R-(R*,R*))-
  • (R)-(-)-CYSTINE
  • (R,R)-(-)-CYSTINE
  • (R,R)-3,3'-DITHIOBIS(2-AMINOPROPIONIC ACID)
  • l-cysteinedisulfide
  • l-cystin
  • L-Dicystiene
  • BETA,BETA'-DITHIOBIS-A-AMINOPROPIONIC ACID
  • CYSTINE, L-
  • (CYS)2
  • (H-CYS-OH)2
  • H-L-CYSTINE
  • L(-)-3,3'-DITHIOBIS(2-AMINOPROPANOIC ACID)
  • L-(-)-CYSTINE
  • L-CYSTINE
  • L-CYSTINE extrapure
  • gelucystine
  • L-3, 31-dithiobis (2-aminopropanoic acid)
  • L-Cystinic acid
  • L-β,β'-Dithiobis(2-amino-pro-panoic acid)
  • L-Cystine, Metal binding, protein structure, antioxidant
  • (2R)-2-Amino-3-[(2R)-2-amino-3-hydroxy-3-oxopropyl]disulfanylpropanoic acid
  • L-(-)-3,3'-Dithiobis (2-aminopropionic acid)
  • 3,3'-Dithiobis(L-alanine)
  • (2S,7S)-(-)-Cystine
  • L-CYSTINERESEARCH GRADE