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CIS-DECAHYDROISOQUINOLINE

Product Name
CIS-DECAHYDROISOQUINOLINE
CAS No.
2744-08-3
Chemical Name
CIS-DECAHYDROISOQUINOLINE
Synonyms
decahydrosoquinoline;CIS-DECAHYDROISOQUINOLINE;rel-(4aR,8aR)-Decahydroisoquinoline;Isoquinoline, decahydro-, (4aR,8aR)-rel-
CBNumber
CB6405311
Molecular Formula
C9H17N
Formula Weight
139.24
MOL File
2744-08-3.mol
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CIS-DECAHYDROISOQUINOLINE Property

Boiling point:
202.5±0.0 °C(Predicted)
Density 
0,95 g/cm3
pka
11.84±0.20(Predicted)
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Safety

Risk Statements 
36/37/38
Safety Statements 
26-36/37/39
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
D212140
Product name
cis-Decahydroisoquinoline
Packaging
500mg
Price
$175
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD65746
Product name
cis-Decahydroisoquinoline
Packaging
1g
Price
$79
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD65746
Product name
cis-Decahydroisoquinoline
Packaging
2g
Price
$142
Updated
2021/12/16
Matrix Scientific
Product number
085568
Product name
cis-Decahydroisoquinoline
Purity
97%
Packaging
1g
Price
$249
Updated
2021/12/16
Biosynth Carbosynth
Product number
FD65746
Product name
cis-Decahydroisoquinoline
Packaging
5G
Price
$260
Updated
2021/12/16
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CIS-DECAHYDROISOQUINOLINE Chemical Properties,Usage,Production

Uses

(4aR,8aR)-Decahydroisoquinoline is a synthetic building block predominately used in the synthesis of natural products.

Purification Methods

The free base is treated with saturated aqueous picric acid, allowed to stand for 12hours, filtered, washed with MeOH to remove the more soluble trans isomer and recrystallised from MeOH to give pure cis-picrate m 149-150o. The picrate (~5g) is shaken with 5M aqueous NaOH (50mL) and Et2O (150mL) while H2O is added to the aqueous phase to dissolve insoluble Na picrate. The Et2O extract is dried over solid NaOH and then shaken with Al2O3 (Merck for chromatography) until the yellow color of traces of picric acid disappears (this color cannot be removed by repeated shaking with 5-10 M aqueous NaOH). The extract is concentrated to 50mL and dry HCl is bubbled through until separation of the white crystals of the cis-HCl is complete. These are washed with Et2O, dried at 100o and recrystallised from EtOH/EtOAc to yield pure cis-hydrochloride m 182-183o (dried in a vacuum desiccator over KOH) with IR (KBr) 2920, 2820, 1582, 1470, 1445, 1410, 1395, max 1313, 1135, 1080, 990, 870 cm-1 . The pure free base is prepared by dissolving the hydrochloride in 10M aqueous NaOH, extracted with Et2O, dried over solid KOH, filtered and distilled in a vacuum. It has IR (film) max 2920, 2820, 2720, 2560, 1584, 1470, 1445, 1415, 1395, 1315, 1300, 1135, 1080, 1020, 990, 873 cm-1 . The 1HNMR in CDCl3 is characteristically different from that of the trans-isomer. [Armarego J Chem Soc (C) 377 1967, Gray & Heitmeier J Am Chem Soc 80 6274 1958, Witkop J Am Chem Soc 70 2617 1948, Skita Chem Ber 57 1982 1924, Helfer Helv Chim Acta 6 7991923, Beilstein 20 II 73, 20 III/IV 2026.]

CIS-DECAHYDROISOQUINOLINE Preparation Products And Raw materials

Raw materials

Preparation Products

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CIS-DECAHYDROISOQUINOLINE Suppliers

SPIRO PHARMA
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Email
eric_feng1954@126.com
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China
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9248
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Jiangsu yize medical technology co. LTD
Tel
18550739526
Fax
QQ: 3394205705
Email
23903480@qq.com
Country
China
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5840
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Jiangsu yize medical technology co. LTD
Tel
18962082606
Email
3394205705@qq.com
Country
China
ProdList
9834
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58
Carbosynth
Tel
--
Fax
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Email
sales@carbosynth.com
Country
United Kingdom
ProdList
6005
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58

2744-08-3, CIS-DECAHYDROISOQUINOLINERelated Search:


  • decahydrosoquinoline
  • CIS-DECAHYDROISOQUINOLINE
  • rel-(4aR,8aR)-Decahydroisoquinoline
  • Isoquinoline, decahydro-, (4aR,8aR)-rel-
  • 2744-08-3
  • Quinolines, Quinazolines and derivatives