ChemicalBook > CAS DataBase List > 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE

7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE

Product Name: 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE
CAS No.: 227940-70-7
Chemical Name: 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE
Synonyms: 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE;3-Boc-7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane;7-Benzyl-3-Boc-3,7-dizalbicylclo[3.3.1]nonan-9-one;tert-butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate;7-Benzyl-9-oxo-3,7-diaza-bicyclo3.3.1none-3-carboxylic acid tert-butyl ester;tert-butyl (1r,5s)-7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate;7-Benzyl-9-oxo-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester;3,7-Diazabicyclo[3.3.1]nonane-3-carboxylic acid, 9-oxo-7-(phenylmethyl)-, 1,1-dimethylethyl ester
CBNumber: CB6407830
Molecular Formula: C19H26N2O3
Formula Weight: 330.42
MOL File: 227940-70-7.mol

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7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE Property

storage temp.: 2-8°C
Appearance: Off-white to light yellow Solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific

Product number: 069015
Product name: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
Purity: >95%
Packaging: 1g
Price: $365
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CHM0379311
Product name: 7-BENZYL-3-BOC-3,7-DIAZABICYCLO-[3.3.1]-NONAN-9-ONE
Purity: 95.00%
Packaging: 5MG
Price: $504.06
Updated: 2021/12/16

Matrix Scientific

Product number: 069015
Product name: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
Purity: >95%
Packaging: 5g
Price: $645
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 35151
Product name: tert-Butyl7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
Purity: 95+%
Packaging: 1g
Price: $650
Updated: 2021/12/16

Matrix Scientific

Product number: 069015
Product name: tert-Butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate
Purity: >95%
Packaging: 250mg
Price: $983
Updated: 2021/12/16

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7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE Chemical Properties,Usage,Production

Synthesis

50-00-0

79099-07-3

100-46-9

227940-70-7

To a solution of methanol (20 mL) containing N-tert-butoxycarbonyl-4-piperidone (3 g, 15.06 mmol), benzylamine (1.73 mL, 15.81 mmol), and acetic acid (0.86 mL, 15.06 mmol) was added a suspension of paraformaldehyde (1 g, in 30 mL of methanol) under stirring. The reaction mixture was heated to reflux and stirred for 1 hour, followed by the addition of paraformaldehyde (1 g) and continued stirring for 4 hours. Upon completion of the reaction, the mixture was cooled to room temperature and concentrated. The concentrated residue was dissolved in ether (40 mL) and alkalized by adding 1M potassium hydroxide solution (20 mL). The organic layer was separated and the aqueous phase was extracted four times with ether. The organic phases were combined, dried with anhydrous sodium sulfate for 20 min, filtered and concentrated. The resulting yellow residue was purified by fast chromatography (silica gel 80 g, elution gradient: 0 to 50% ethyl acetate/hexane, 20 min) to afford tert-butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate (5 g, 100% yield). lRMS (ESI): m/z Calculated value [M+H]+ 330.19, measured value 362.9 ([M+MeOH]+).

References

[1] Patent: WO2008/55068, 2008, A2. Location in patent: Page/Page column 176-177
[2] Patent: WO2009/137503, 2009, A1. Location in patent: Page/Page column 57-58
[3] Patent: US2017/749, 2017, A1. Location in patent: Paragraph 0558
[4] Tetrahedron, 2015, vol. 71, # 15, p. 2241 - 2245
[5] Chemical communications (Cambridge, England), 2002, # 7, p. 673 - 675

7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE Preparation Products And Raw materials

Raw materials

Preparation Products

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227940-70-7, 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONERelated Search:

N-BENZYL-BISPIDINE R-3-(Dimethylaminomethyl)-N-Boc-piperidine N-[(3R)-3-PIPERIDINYLMETHYL]-CARBAMIC ACID 1,1-DIMETHYLETHYL ESTER (R)-N-Boc-3-aminomethylpiperidine 3-N-Boc-Aminomethylpiperidine 3-N-BOC-3-N-METHYL-AMINOMETHYL PIPERIDINE 3-Methyl-4-oxo-1-piperidinecarboxylic acid ethyl ester (S)-N-Boc-3-aminomethylpiperidine 1-BOC-3-METHYL-PIPERIDIN-4-ONE (S)-3-(Dimethylaminomethyl)-N-Boc-piperidine 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONANE 7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE

7-BENZYL-3-BOC-3,7-DIAZABICYCLO[3.3.1]NONAN-9-ONE

7-Benzyl-9-oxo-3,7-diaza-bicyclo3.3.1none-3-carboxylic acid tert-butyl ester

7-Benzyl-3-Boc-3,7-dizalbicylclo[3.3.1]nonan-9-one

tert-butyl 7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

7-Benzyl-9-oxo-3,7-diaza-bicyclo[3.3.1]nonane-3-carboxylic acid tert-butyl ester

3-Boc-7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane

3,7-Diazabicyclo[3.3.1]nonane-3-carboxylic acid, 9-oxo-7-(phenylmethyl)-, 1,1-dimethylethyl ester

tert-butyl (1r,5s)-7-benzyl-9-oxo-3,7-diazabicyclo[3.3.1]nonane-3-carboxylate

227940-70-7

pharmacetical