Felodipine
- Product Name
- Felodipine
- CAS No.
- 86189-69-7
- Chemical Name
- Felodipine
- Synonyms
- FLODIL;FELODAY;Agon sr;Perfuda;Perfudal;Felodipina;Felodipine;Brn 4331472;Felodipine Imp;Felodipine iMpurity
- CBNumber
- CB6411200
- Molecular Formula
- C18H19Cl2NO4
- Formula Weight
- 384.25
- MOL File
- 86189-69-7.mol
Felodipine Property
- solubility
- DMSO: 28 mg/mL
- form
- solid
- color
- light yellow
- BCS Class
- 2
- CAS DataBase Reference
- 86189-69-7(CAS DataBase Reference)
Felodipine Chemical Properties,Usage,Production
Uses
Vasodilator.
brand name
Plendil (AstraZeneca).
Clinical Use
Calcium-channel blocker:HypertensionAngina
Drug interactions
Potentially hazardous interactions with other drugs Aminophylline and theophylline: possibly increased aminophylline and theophylline concentration. Anaesthetics: enhanced hypotensive effect. Antibacterials metabolism possibly inhibited by clarithromycin, erythromycin and telithromycin. Antidepressants: enhanced hypotensive effect with MAOIs. Antiepileptics: effect reduced by carbamazepine, barbiturates, phenytoin and primidone. Antifungals: metabolism inhibited by itraconazole and ketoconazole; negative inotropic effect possibly increased with itraconazole. Antihypertensives: enhanced hypotensive effect, increased risk of first dose hypotensive effect of postsynaptic alpha-blockers. Antivirals: concentration possibly increased by ritonavir; use with caution with telaprevir. Grapefruit juice: concentration increased - avoid concomitant use. Tacrolimus: possibly increased tacrolimus concentration
Metabolism
Felodipine is metabolised in the liver and all identified metabolites are devoid of vasodilating properties. Approximately 70% of a given dose is excreted as metabolites in the urine and about 10% with the faeces. Less than 0.5% of the dose is excreted unchanged in the urin
Felodipine Preparation Products And Raw materials
Raw materials
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View Lastest Price from Felodipine manufacturers
- Product
- Felodipine 86189-69-7
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-08-06
- Product
- FELODIPINE 86189-69-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-08
- Product
- 5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 86189-69-7
- Price
- US $60.00/KG
- Min. Order
- 10g
- Purity
- 99.8%
- Supply Ability
- 10tons
- Release date
- 2019-11-01