ChemicalBook > CAS DataBase List > Felodipine

Felodipine

Product Name: Felodipine
CAS No.: 86189-69-7
Chemical Name: Felodipine
Synonyms: FLODIL;FELODAY;Agon sr;Perfuda;Perfudal;Felodipina;Brn 4331472;Felodipine Imp;Felodipine iMpurity;Felodipine Powder USP Standard
CBNumber: CB6411200
Molecular Formula: C18H19Cl2NO4
Formula Weight: 384.25
MOL File: 86189-69-7.mol

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Felodipine Property

solubility: DMSO: 28 mg/mL
form: solid
color: light yellow
BCS Class: 2
InChI: InChI=1S/C18H19Cl2NO4/c1-5-25-18(23)14-10(3)21-9(2)13(17(22)24-4)15(14)11-7-6-8-12(19)16(11)20/h6-8,15,21H,5H2,1-4H3
InChIKey: RZTAMFZIAATZDJ-UHFFFAOYSA-N
SMILES: O=C(OC)C1C(C2=C(Cl)C(Cl)=CC=C2)C(C(=O)OCC)=C(C)NC=1C
CAS DataBase Reference: 86189-69-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xn
Risk Statements: 22
WGK Germany: 3
RTECS: US7968700

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Hazard and Precautionary Statements (GHS)

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Felodipine Chemical Properties,Usage,Production

Uses

Vasodilator.

brand name

Plendil (AstraZeneca).

Clinical Use

Calcium-channel blocker:
Hypertension
Angina

Drug interactions

Potentially hazardous interactions with other drugs
Aminophylline and theophylline: possibly increased aminophylline and theophylline concentration.
Anaesthetics: enhanced hypotensive effect.
Antibacterials metabolism possibly inhibited by clarithromycin, erythromycin and telithromycin.
Antidepressants: enhanced hypotensive effect with MAOIs.
Antiepileptics: effect reduced by carbamazepine, barbiturates, phenytoin and primidone.
Antifungals: metabolism inhibited by itraconazole and ketoconazole; negative inotropic effect possibly increased with itraconazole.
Antihypertensives: enhanced hypotensive effect, increased risk of first dose hypotensive effect of postsynaptic alpha-blockers.
Antivirals: concentration possibly increased by ritonavir; use with caution with telaprevir.
Grapefruit juice: concentration increased - avoid concomitant use.
Tacrolimus: possibly increased tacrolimus concentration

Metabolism

Felodipine is metabolised in the liver and all identified metabolites are devoid of vasodilating properties. Approximately 70% of a given dose is excreted as metabolites in the urine and about 10% with the faeces. Less than 0.5% of the dose is excreted unchanged in the urin

Felodipine Preparation Products And Raw materials

Raw materials

Preparation Products

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Felodipine Suppliers

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View Lastest Price from Felodipine manufacturers

Zhuozhou Wenxi import and Export Co., Ltd

Product: FELODIPINE 86189-69-7
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-08

Hebei shuoxi biotechnology co. LTD

Product: 5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate 86189-69-7
Price: US $60.00/KG
Min. Order: 10g
Purity: 99.8%
Supply Ability: 10tons
Release date: 2019-11-01

Career Henan Chemical Co

Product: Felodipine 86189-69-7
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2018-12-17

86189-69-7, FelodipineRelated Search:

Dimethyl fumarate Dimethyl sulfoxide Dimethyl sulfate Dichlorodimethylsilane Dimethyl ether Dimethyl carbonate ETHANE Poly(dimethylsiloxane) Chlorodimethylphenylsilane Dichlorodiphenylsilane N,N-Dimethylformamide N,N-Dimethylacetamide Methyl FELODIPINE IMP.C ( EP) :DIETHYL-4-(2,3-DICHLOROPHENYL)-2,6-DIMETHYL-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE Methyl bromide FELODIPINE IMP.A ( EP) :ETHYL METHYL-4-(2,3-DICHLOROPHENYL)-2,6-DIMETHYLPYRIDINE-3,5-DICARBOXYLATE Bicalutamide Felodipine

4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINECARBOXYLIC ACID METHYL ESTER

4-(2,3-DICHLOROPHENYL)-1,4-DIHYDRO-2,6-DIMETHYL-3,5-PYRIDINEDICARBOXYLIC ACID METHYL ESTER

FLODIL

FELODAY

ethyl methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Agon sr

Brn 4331472

Felodipina

3-ethyl 5-Methyl (4R)-4-(2,3-dichlorophenyl)-2,6-diMethyl-1,4-dihydropyridine-3,5-dicarboxylate

Felodipine iMpurity

Felodipine Imp

5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate

Perfuda

Perfudal

5-O-ethyl 3-O-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1

Felodipine Powder USP Standard

FELODIPINE USP, NON-STERILE DRUG SUBSTANCE

86189-69-7

Cell Biology

Cell Signaling and Neuroscience

Calcium Channel Modulators

BioChemical

Inhibitors and Activators

Ion Channels

Voltage-gated Ion Channels