2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER

Product Name: 2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
CAS No.: 4815-32-1
Chemical Name: 2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER
Synonyms: AKOS B000754;AKOS MSC-0422;BUTTPARK 145\06-94;CHEMBRDG-BB 4143064;2-Amino-3-carboethoxy-5-methylthiophene;2-Amino-5-methyl-3-ethoxycarbonylthiophene;ETHYL 2-AMINO-5-METHYLTHIOPHENE-3-CARBOXYLATE;ETHYL 2-AMINO-5-METHYL-3-THIOPHENECARBOXYLATE;2-amino-5-methyl-thiene-3-formate ethyl ester;2-amino-5-methyl-3-thiophenecarboxylic acid ethyl ester
CBNumber: CB6425241
Molecular Formula: C8H11NO2S
Formula Weight: 185.24
MOL File: 4815-32-1.mol

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2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Property

Melting point:: 47.0 to 51.0 °C
Boiling point:: 292℃
Density: 1.219±0.06 g/cm3(Predicted)
Flash point:: 131℃
storage temp.: 2-8°C(protect from light)
form: Solid
pka: 0.43±0.10(Predicted)
color: White to Light yellow

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Safety

Hazard Codes: Xi
Risk Statements: 20/21/22
Safety Statements: 3/7-36/37
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: E1104
Product name: Ethyl 2-Amino-5-methylthiophene-3-carboxylate
Purity: >98.0%(GC)
Packaging: 1g
Price: $112
Updated: 2025/07/31

TCI Chemical

Product number: E1104
Product name: Ethyl 2-Amino-5-methylthiophene-3-carboxylate
Purity: >98.0%(GC)
Packaging: 5g
Price: $533
Updated: 2021/12/16

TRC

Product number: B433773
Product name: Ethyl 2-Amino-5-methylthiophene-3-carboxylate
Packaging: 50mg
Price: $45
Updated: 2021/12/16

TRC

Product number: B433773
Product name: Ethyl 2-Amino-5-methylthiophene-3-carboxylate
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Matrix Scientific

Product number: 028912
Product name: Ethyl 2-amino-5-methylthiophene-3-carboxylate
Packaging: 500mg
Price: $58
Updated: 2021/12/16

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2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Chemical Properties,Usage,Production

Chemical Properties

Light yellow solid

Uses

Ethyl 2-amino-5-methylthiophene-3-carboxylate is a useful intermediate for the Gewald synthesis of 2-aminothiophenes.

Synthesis

123-38-6

105-56-6

4815-32-1

Ethyl cyanoacetate (56.6 g, 0.5 mol), sulfur powder (16.0 g, 0.5 mol) and triethylamine (50.5 g, 0.5 mol) were added sequentially to a three-necked flask containing N,N-dimethylformamide (DMF, 100 mL) and stirred until completely dissolved. Subsequently, a solution of propionaldehyde (31.9 g, 0.55 mol) in acetaldehyde (15 mL) was added slowly and dropwise. During the reaction, the internal temperature was naturally increased to 60 °C and heated at this temperature with continuous stirring. Upon completion of the reaction, the reaction mixture was slowly poured into water and extracted with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate, and the solvent was removed by distillation under reduced pressure. The resulting crude product was purified by silica gel column chromatography (MERCK Kiesel gel 60, eluent 20% ethyl acetate-hexane) to afford ethyl 2-amino-5-methylthiophene-3-carboxylate (81.8 g, 89% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 1.33 (t, 3H, J = 7.2 Hz), 2.26 (d, 3H, J = 1.2 Hz), 4.25 (q, 2H, J = 7.2 Hz), 5.76 (br.s, 2H), 6.61 (q, 1H, J = 1.2 Hz).

References

[1] Patent: EP1544202, 2005, A1. Location in patent: Page/Page column 53-54
[2] Journal of Sulfur Chemistry, 2014, vol. 35, # 3, p. 261 - 269
[3] Patent: US2009/131455, 2009, A1. Location in patent: Page/Page column 8
[4] Monatshefte fur Chemie, 2017, vol. 148, # 4, p. 711 - 716
[5] European Journal of Medicinal Chemistry, 2018, vol. 154, p. 324 - 340

2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Preparation Products And Raw materials

Raw materials

Sulfur N,N-Dimethylformamide Propionaldehyde Triethylamine Ethyl cyanoacetate

Preparation Products

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2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Suppliers

Americas 1 China 82 Europe 1 Germany 1 India 3 Japan 1 Russia 2 Ukraine 1 United Kingdom 3 United States 12 Global 107

J & K SCIENTIFIC LTD.

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View Lastest Price from 2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl 2-amino-5-methylthiophene-3-carboxylate 4815-32-1
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-07-26

Shaanxi Dideu Medichem Co. Ltd

Product: Ethyl 2-amino-5-methylthiophene-3-carboxylate 4815-32-1
Price: US $1.00-22.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100000KG
Release date: 2024-07-26

Career Henan Chemical Co

Product: 2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 4815-32-1
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-07-10

4815-32-1, 2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTERRelated Search:

ETHYL 2-AMINO-5-ETHYLTHIOPHENE-3-CARBOXYLATE ETHYL 2-AMINO-4,5-DIMETHYLTHIOPHENE-3-CARBOXYLATE DIETHYL 5-AMINO-3-METHYL-2,4-THIOPHENEDICARBOXYLATE 2-AMINO-4,5,6,7-TETRAHYDRO-BENZO[B]THIOPHENE-3-CARBOXYLIC ACID METHYL ESTER 2-AMINO-5,6-DIHYDRO-4H-CYCLOPENTA[B]THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER 2-AMINO-4-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER Ethyl thiophene-3-carboxylate ethyl 5-acetyl-2-amino-4-methyl-thiophene-3-carboxylate ETHYL 2-ACETAMIDO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE ETHYL 2-[(2-CHLOROACETYL)AMINO]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-3-CARBOXYLATE 5-AMINO-3-METHYL-THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER AURORA 3766 ETHYL 2-(((4-CHLOROPHENYL)AMINO)CARBONYLAMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE AKOS 93369 ETHYL 2-((THIOXO((4-(TRIFLUOROMETHOXY)PHENYL)AMINO)METHYL)AMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE ETHYL 2-((2,2-DICYANOVINYL)AMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE AKOS 89941 ETHYL 2-(((1,3-DIOXOINDAN-2-YLIDENE)METHYL)AMINO)-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE

BUTTPARK 145\06-94

ETHYL 2-AMINO-5-METHYL-3-THIOPHENECARBOXYLATE

ETHYL 2-AMINO-5-METHYLTHIOPHENE-3-CARBOXYLATE

CHEMBRDG-BB 4143064

AKOS MSC-0422

AKOS B000754

2-AMINO-5-METHYL-THIOPHENE-3-CARBOXYLIC ACID ETHYL ESTER

2-Amino-5-methyl-thiophene-3-carboxylic acid ethyl ester ,97%

ethyl 2-amino-5-methylthiophene-3-carboxylate(SALTDATA: FREE)

3-Thiophenecarboxylic acid, 2-aMino-5-Methyl-, ethyl ester

2-Amino-3-carboethoxy-5-methylthiophene

2-Amino-5-methyl-3-ethoxycarbonylthiophene

2-amino-5-methyl-3-thiophenecarboxylic acid ethyl ester

2-amino-5-methyl-thiene-3-formate ethyl ester

4815-32-1