ChemicalBook > CAS DataBase List > L-Proline benzyl ester hydrochloride

L-Proline benzyl ester hydrochloride

Product Name
L-Proline benzyl ester hydrochloride
CAS No.
16652-71-4
Chemical Name
L-Proline benzyl ester hydrochloride
Synonyms
H-PRO-OBZL;PRO-OBZL HCL;H-Pro-Obzl.Hc;H-PRO-OBZL HCL;H-PRO-OBZL·HCL;L-Pro-OBzl.HCl;H-Pro-OBzI.HCI;H-Pro-OBzl.HCI;H-Pro-OBz1.HCI;PROLINE-OBZL HCL
CBNumber
CB6426051
Molecular Formula
C12H16ClNO2
Formula Weight
241.71
MOL File
16652-71-4.mol
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L-Proline benzyl ester hydrochloride Property

Melting point:
148-151 °C(lit.)
alpha 
-44 º (c=1, methanol)
refractive index 
1.4365
storage temp. 
Inert atmosphere,Room Temperature
solubility 
soluble in Methanol
form 
Crystalline Powder
color 
White to pale yellow
optical activity
[α]20/D 48°, c = 1 in H2O
Water Solubility 
miscible
Sensitive 
Hygroscopic
BRN 
3598081
InChI
InChI=1/C12H15NO2.ClH/c14-12(11-7-4-8-13-11)15-9-10-5-2-1-3-6-10;/h1-3,5-6,11,13H,4,7-9H2;1H/t11-;/s3
InChIKey
NEDMOHHWRPHBAL-MERQFXBCSA-N
SMILES
[C@@H]1(NCCC1)C(=O)OCC1=CC=CC=C1.Cl |&1:0,r|
CAS DataBase Reference
16652-71-4(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/38-36/37/38-22
Safety Statements 
22-24/25-37/39-26-36/37/39
WGK Germany 
3
HS Code 
29339900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
364460
Product name
L-Proline benzyl ester hydrochloride
Purity
98%
Packaging
5g
Price
$34.72
Updated
2025/07/31
TCI Chemical
Product number
P1727
Product name
L-Proline Benzyl Ester Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
5g
Price
$21
Updated
2025/07/31
TCI Chemical
Product number
P1727
Product name
L-Proline Benzyl Ester Hydrochloride
Purity
>98.0%(HPLC)(T)
Packaging
25g
Price
$66
Updated
2025/07/31
TRC
Product number
P756025
Product name
L-Proline benzyl ester hydrochloride
Packaging
25g
Price
$115
Updated
2021/12/16
TRC
Product number
P756025
Product name
L-Proline benzyl ester hydrochloride
Packaging
5g
Price
$45
Updated
2021/12/16
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L-Proline benzyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

L-Proline Benzyl Ester Hydrochloride acts as a reagent in the synthesis and bioactivity of a goralatide analog with anti-leukemic activity.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

147-85-3

100-51-6

16652-71-4

Under nitrogen protection, benzyl alcohol (70 mL, 651 mmol) was cooled to 0 °C and thionyl chloride (7.0 mL, 91.2 mmol) was added slowly and dropwise. L-proline (5.0 g, 43.4 mmol) was then added, and the reaction system was kept stirred at 0 °C and under nitrogen atmosphere for 2 hours. The temperature was slowly increased to room temperature and stirring was continued for 48 hours. Upon completion of the reaction, the reaction mixture was slowly poured into ether (300 mL) and left to crystallize at -20°C for 7 days. The resulting white solid precipitate was collected by filtration, washed with ether and dried under vacuum to give L-proline benzyl ester hydrochloride (9.88 g, 93% yield). The product characterization data were as follows: melting point 142.1-144.0 °C (literature value: 143-144 °C); 1H NMR (300 MHz, CDCl3): δ 7.41-7.21 (m, 5H), 5.16 (s, 2H), 3.80 (dd, J = 3.83, 5.9 Hz, 1H), 3.15-3.01 (m, 1H), 3.00-2.82 (m, 1H), 2.42-2.21 (m, 1H), 2.13 (dd, J = 12.9, 7.5 Hz, 1H), 1.92-1.62 (m, 3H); 13C NMR (75 MHz, CDCl3): δ 175.5, 136.0, 128.8, 128.5, 128.3, 66.9, 59.9, 47.2, 30.4, 25.6. Elemental analysis (C12H16ClNO2) calculated values: C, 59.63; H, 6.67; N, 5.79; measured values: C, 59.50; H, 6.86; N, 5.64.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 5056 - 5060
[2] Tetrahedron, 2010, vol. 66, # 29, p. 5384 - 5395
[3] Patent: CN105061283, 2017, B. Location in patent: Paragraph 0030-0032; 0045-0047; 0057
[4] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1959, p. 1851; engl. Ausg. S. 1768, 1769
[5] Journal of Biological Chemistry, 1951, vol. 193, p. 97,108

L-Proline benzyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from L-Proline benzyl ester hydrochloride manufacturers

RongNa Biotechnology Co.,Ltd
Product
L-Proline benzyl ester hydrochloride 16652-71-4
Price
US $1.00/g
Min. Order
1g
Purity
99%
Supply Ability
1000kg
Release date
2025-08-20
Henan Aochuang Chemical Co.,Ltd.
Product
L-Proline benzyl ester hydrochloride 16652-71-4
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-10-17
Career Henan Chemical Co
Product
L-Proline benzyl ester hydrochloride 16652-71-4
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20kg
Release date
2018-08-15

16652-71-4, L-Proline benzyl ester hydrochlorideRelated Search:

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