L-Proline benzyl ester hydrochloride

Product Name: L-Proline benzyl ester hydrochloride
CAS No.: 16652-71-4
Chemical Name: L-Proline benzyl ester hydrochloride
Synonyms: H-PRO-OBZL;PRO-OBZL HCL;H-Pro-Obzl.Hc;H-PRO-OBZL HCL;H-PRO-OBZL·HCL;L-Pro-OBzl.HCl;H-Pro-OBzI.HCI;H-Pro-OBzl.HCI;H-Pro-OBz1.HCI;PROLINE-OBZL HCL
CBNumber: CB6426051
Molecular Formula: C12H16ClNO2
Formula Weight: 241.71
MOL File: 16652-71-4.mol

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L-Proline benzyl ester hydrochloride Property

Melting point:: 148-151 °C(lit.)
alpha: -44 º (c=1, methanol)
refractive index: 1.4365
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: Crystalline Powder
color: White to pale yellow
optical activity: [α]20/D 48°, c = 1 in H2O
Water Solubility: miscible
Sensitive: Hygroscopic
BRN: 3598081
InChI: InChI=1/C12H15NO2.ClH/c14-12(11-7-4-8-13-11)15-9-10-5-2-1-3-6-10;/h1-3,5-6,11,13H,4,7-9H2;1H/t11-;/s3
InChIKey: NEDMOHHWRPHBAL-MERQFXBCSA-N
SMILES: [C@@H]1(NCCC1)C(=O)OCC1=CC=CC=C1.Cl |&1:0,r|
CAS DataBase Reference: 16652-71-4(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/38-36/37/38-22
Safety Statements: 22-24/25-37/39-26-36/37/39
WGK Germany: 3
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 364460
Product name: L-Proline benzyl ester hydrochloride
Purity: 98%
Packaging: 5g
Price: $34.72
Updated: 2025/07/31

TCI Chemical

Product number: P1727
Product name: L-Proline Benzyl Ester Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 5g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: P1727
Product name: L-Proline Benzyl Ester Hydrochloride
Purity: >98.0%(HPLC)(T)
Packaging: 25g
Price: $66
Updated: 2025/07/31

TRC

Product number: P756025
Product name: L-Proline benzyl ester hydrochloride
Packaging: 5g
Price: $45
Updated: 2021/12/16

TRC

Product number: P756025
Product name: L-Proline benzyl ester hydrochloride
Packaging: 25g
Price: $115
Updated: 2021/12/16

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L-Proline benzyl ester hydrochloride Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

L-Proline Benzyl Ester Hydrochloride acts as a reagent in the synthesis and bioactivity of a goralatide analog with anti-leukemic activity.

reaction suitability

reaction type: solution phase peptide synthesis

Synthesis

147-85-3

100-51-6

16652-71-4

Under nitrogen protection, benzyl alcohol (70 mL, 651 mmol) was cooled to 0 °C and thionyl chloride (7.0 mL, 91.2 mmol) was added slowly and dropwise. L-proline (5.0 g, 43.4 mmol) was then added, and the reaction system was kept stirred at 0 °C and under nitrogen atmosphere for 2 hours. The temperature was slowly increased to room temperature and stirring was continued for 48 hours. Upon completion of the reaction, the reaction mixture was slowly poured into ether (300 mL) and left to crystallize at -20°C for 7 days. The resulting white solid precipitate was collected by filtration, washed with ether and dried under vacuum to give L-proline benzyl ester hydrochloride (9.88 g, 93% yield). The product characterization data were as follows: melting point 142.1-144.0 °C (literature value: 143-144 °C); 1H NMR (300 MHz, CDCl3): δ 7.41-7.21 (m, 5H), 5.16 (s, 2H), 3.80 (dd, J = 3.83, 5.9 Hz, 1H), 3.15-3.01 (m, 1H), 3.00-2.82 (m, 1H), 2.42-2.21 (m, 1H), 2.13 (dd, J = 12.9, 7.5 Hz, 1H), 1.92-1.62 (m, 3H); 13C NMR (75 MHz, CDCl3): δ 175.5, 136.0, 128.8, 128.5, 128.3, 66.9, 59.9, 47.2, 30.4, 25.6. Elemental analysis (C12H16ClNO2) calculated values: C, 59.63; H, 6.67; N, 5.79; measured values: C, 59.50; H, 6.86; N, 5.64.

References

[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 5056 - 5060
[2] Tetrahedron, 2010, vol. 66, # 29, p. 5384 - 5395
[3] Patent: CN105061283, 2017, B. Location in patent: Paragraph 0030-0032; 0045-0047; 0057
[4] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1959, p. 1851; engl. Ausg. S. 1768, 1769
[5] Journal of Biological Chemistry, 1951, vol. 193, p. 97,108

L-Proline benzyl ester hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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RongNa Biotechnology Co.,Ltd

Product: L-Proline benzyl ester hydrochloride 16652-71-4
Price: US $1.00/g
Min. Order: 1g
Purity: 99%
Supply Ability: 1000kg
Release date: 2025-08-20

Henan Aochuang Chemical Co.,Ltd.

Product: L-Proline benzyl ester hydrochloride 16652-71-4
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-10-17

Career Henan Chemical Co

Product: L-Proline benzyl ester hydrochloride 16652-71-4
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20kg
Release date: 2018-08-15

16652-71-4, L-Proline benzyl ester hydrochlorideRelated Search:

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16652-71-4

C12H15NO2HCI

C12H15NO2ClH

C12H15NO2xHCl

AMINE

Specialty Synthesis

Peptide Synthesis

Amino Acid Derivatives

Proline [Pro, P]

Amino Acids and Derivatives

Amino Acid Benzyl Esters

Amino Acids (C-Protected)

Biochemistry

Amino hydrochloride

Amino Acid Derivatives

Peptide Synthesis

Proline