L-Proline benzyl ester hydrochloride
- Product Name
- L-Proline benzyl ester hydrochloride
- CAS No.
- 16652-71-4
- Chemical Name
- L-Proline benzyl ester hydrochloride
- Synonyms
- H-PRO-OBZL;PRO-OBZL HCL;H-Pro-Obzl.Hc;H-PRO-OBZL HCL;H-PRO-OBZL·HCL;L-Pro-OBzl.HCl;H-Pro-OBzI.HCI;H-Pro-OBzl.HCI;H-Pro-OBz1.HCI;PROLINE-OBZL HCL
- CBNumber
- CB6426051
- Molecular Formula
- C12H16ClNO2
- Formula Weight
- 241.71
- MOL File
- 16652-71-4.mol
L-Proline benzyl ester hydrochloride Property
- Melting point:
- 148-151 °C(lit.)
- alpha
- -44 º (c=1, methanol)
- refractive index
- 1.4365
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- soluble in Methanol
- form
- Crystalline Powder
- color
- White to pale yellow
- optical activity
- [α]20/D 48°, c = 1 in H2O
- Water Solubility
- miscible
- Sensitive
- Hygroscopic
- BRN
- 3598081
- InChI
- InChI=1/C12H15NO2.ClH/c14-12(11-7-4-8-13-11)15-9-10-5-2-1-3-6-10;/h1-3,5-6,11,13H,4,7-9H2;1H/t11-;/s3
- InChIKey
- NEDMOHHWRPHBAL-MERQFXBCSA-N
- SMILES
- [C@@H]1(NCCC1)C(=O)OCC1=CC=CC=C1.Cl |&1:0,r|
- CAS DataBase Reference
- 16652-71-4(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/38-36/37/38-22
- Safety Statements
- 22-24/25-37/39-26-36/37/39
- WGK Germany
- 3
- HS Code
- 29339900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
N-Bromosuccinimide Price
- Product number
- 364460
- Product name
- L-Proline benzyl ester hydrochloride
- Purity
- 98%
- Packaging
- 5g
- Price
- $34.72
- Updated
- 2025/07/31
- Product number
- P1727
- Product name
- L-Proline Benzyl Ester Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 5g
- Price
- $21
- Updated
- 2025/07/31
- Product number
- P1727
- Product name
- L-Proline Benzyl Ester Hydrochloride
- Purity
- >98.0%(HPLC)(T)
- Packaging
- 25g
- Price
- $66
- Updated
- 2025/07/31
- Product number
- P756025
- Product name
- L-Proline benzyl ester hydrochloride
- Packaging
- 25g
- Price
- $115
- Updated
- 2021/12/16
- Product number
- P756025
- Product name
- L-Proline benzyl ester hydrochloride
- Packaging
- 5g
- Price
- $45
- Updated
- 2021/12/16
L-Proline benzyl ester hydrochloride Chemical Properties,Usage,Production
Chemical Properties
White powder
Uses
L-Proline Benzyl Ester Hydrochloride acts as a reagent in the synthesis and bioactivity of a goralatide analog with anti-leukemic activity.
reaction suitability
reaction type: solution phase peptide synthesis
Synthesis
147-85-3
100-51-6
16652-71-4
Under nitrogen protection, benzyl alcohol (70 mL, 651 mmol) was cooled to 0 °C and thionyl chloride (7.0 mL, 91.2 mmol) was added slowly and dropwise. L-proline (5.0 g, 43.4 mmol) was then added, and the reaction system was kept stirred at 0 °C and under nitrogen atmosphere for 2 hours. The temperature was slowly increased to room temperature and stirring was continued for 48 hours. Upon completion of the reaction, the reaction mixture was slowly poured into ether (300 mL) and left to crystallize at -20°C for 7 days. The resulting white solid precipitate was collected by filtration, washed with ether and dried under vacuum to give L-proline benzyl ester hydrochloride (9.88 g, 93% yield). The product characterization data were as follows: melting point 142.1-144.0 °C (literature value: 143-144 °C); 1H NMR (300 MHz, CDCl3): δ 7.41-7.21 (m, 5H), 5.16 (s, 2H), 3.80 (dd, J = 3.83, 5.9 Hz, 1H), 3.15-3.01 (m, 1H), 3.00-2.82 (m, 1H), 2.42-2.21 (m, 1H), 2.13 (dd, J = 12.9, 7.5 Hz, 1H), 1.92-1.62 (m, 3H); 13C NMR (75 MHz, CDCl3): δ 175.5, 136.0, 128.8, 128.5, 128.3, 66.9, 59.9, 47.2, 30.4, 25.6. Elemental analysis (C12H16ClNO2) calculated values: C, 59.63; H, 6.67; N, 5.79; measured values: C, 59.50; H, 6.86; N, 5.64.
References
[1] Bioorganic and Medicinal Chemistry, 2015, vol. 23, # 15, p. 5056 - 5060
[2] Tetrahedron, 2010, vol. 66, # 29, p. 5384 - 5395
[3] Patent: CN105061283, 2017, B. Location in patent: Paragraph 0030-0032; 0045-0047; 0057
[4] Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1959, p. 1851; engl. Ausg. S. 1768, 1769
[5] Journal of Biological Chemistry, 1951, vol. 193, p. 97,108
L-Proline benzyl ester hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from L-Proline benzyl ester hydrochloride manufacturers
- Product
- L-Proline benzyl ester hydrochloride 16652-71-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1000kg
- Release date
- 2025-08-20
- Product
- L-Proline benzyl ester hydrochloride 16652-71-4
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-10-17
- Product
- L-Proline benzyl ester hydrochloride 16652-71-4
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-15