Description Appearance Solubility Toxicity
ChemicalBook > CAS DataBase List > Piroctone olamine

Piroctone olamine

Description Appearance Solubility Toxicity
Product Name
Piroctone olamine
CAS No.
68890-66-4
Chemical Name
Piroctone olamine
Synonyms
OCTOPIROX;OCTO;1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one;PIROCTONE OLEAMINE;LGB-PO;octopiroxolamine;PIROCTONE OLAMINE;Piorctone Olamine;PiroCLone olaMine;Pirotone Oleamine
CBNumber
CB6433396
Molecular Formula
C16H30N2O3
Formula Weight
298.43
MOL File
68890-66-4.mol
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Piroctone olamine Property

Melting point:
134.0 to 138.0 °C
Boiling point:
135-235℃[at 101 325 Pa]
Density 
1.1[at 20℃]
vapor pressure 
0-0Pa at 20-25℃
storage temp. 
Inert atmosphere,2-8°C
solubility 
Chloroform (Slightly, Sonicated), Methanol (Slightly)
pka
5.9-7.4[at 20 ℃]
color 
White to Off-White
Water Solubility 
400-50000mg/L at 20-25℃
Merck 
14,7502
InChI
InChI=1S/C14H23NO2.C2H7NO/c1-10-6-12(15(17)13(16)8-10)7-11(2)9-14(3,4)5;3-1-2-4/h6,8,11,17H,7,9H2,1-5H3;4H,1-3H2
InChIKey
BTSZTGGZJQFALU-UHFFFAOYSA-N
SMILES
C(N)CO.C(C1=CC(C)=CC(=O)N1O)C(C)CC(C)(C)C
LogP
1.05-3.86 at 20-25℃
CAS DataBase Reference
68890-66-4(CAS DataBase Reference)
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Safety

WGK Germany 
2
RTECS 
UU7786150
HS Code 
2933399090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
51872
Product name
Piroctone olamine
Purity
analytical standard
Packaging
100mg
Price
$142
Updated
2024/03/01
Sigma-Aldrich
Product number
1544406
Product name
Piroctone olamine
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$436
Updated
2024/03/01
TCI Chemical
Product number
P2178
Product name
Piroctone Olamine
Purity
>97.0%(HPLC)(T)
Packaging
1g
Price
$141
Updated
2024/03/01
TCI Chemical
Product number
P2178
Product name
Piroctone Olamine
Purity
>97.0%(HPLC)(T)
Packaging
5g
Price
$471
Updated
2024/03/01
Sigma-Aldrich
Product number
PHR2187
Product name
Piroctone Olamine
Purity
Pharmaceutical Secondary Standard; Certified Reference Material
Packaging
500mg
Price
$689
Updated
2024/03/01
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Piroctone olamine Chemical Properties,Usage,Production

Description

Piroctone olamine (INN; also known as piroctone ethanolamine; brand name Octopirox) is a compound sometimes used in the treatment of fungal infections.Piroctone olamine is the ethanolamine salt of the hydroxamic acid derivative piroctone.

Appearance

White or slightly yellow crystalline powder.

Solubility

Freely soluble in 10% ethanol in water; soluble in solution containing surfactants in water or in 1%-10% ethanol; slightly soluble in water and in oil. The solubility in water varies by pH value, and is a litter larger in neutral or weak basic solution than in acid solution.

Toxicity

Acute toxicity : Acute oral LD50 –rat 8100mg/kg, practically nontoxic.

Subchronic toxicity : NOEL: 100mg//kg/d (rat, orally, 3 months).

Chronic toxicity and carcinogencity : Negative.

Mutagenicity : Negative.

Irritation to skin and eye : Very low.

Uses

Piroctone Olamine is an anti-dandruff agent used in shampoo formulations.

Uses

Piroctone olamine is used in combination with other substances as a part of shampoo effectively reduced the amount of dandruff and, at the same time, provided hair conditioning advantages. Recently was shown, that piroctone olamine could induce apoptosis and possessed a significant in vivo effect against myeloma.

Definition

ChEBI: An organoammonium salt that is the ethanolamine salt of piroctone.

brand name

Octopirox (Hoechst AG, Germany).

Mechanism of action

Piroctone olamine, also known as Octopirox, is an antifungal and antibacterial agent commonly used in cosmetic and personal care products, such as shampoos, conditioners, and lotions. It works by inhibiting the growth of various microorganisms, including yeasts and fungi, by disrupting their cell membranes and interfering with their metabolism. Specifically, piroctone olamine targets the enzymes responsible for synthesizing the cell membrane of microorganisms, inhibiting their growth and causing their eventual death. It also has anti-inflammatory properties that help to reduce redness and itching on the scalp and skin.

Side effects

It should be kept in mind that shampoos with Piroctone Olamine should not be used more than twice a week, unlike other daily-use shampoos that don't have this ingredient. One of the biggest side effects of Piroctone Olamine is that it can cause irritation and itchiness on the head.

Piroctone olamine Preparation Products And Raw materials

Raw materials

Preparation Products

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Piroctone olamine Suppliers

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View Lastest Price from Piroctone olamine manufacturers

Hebei Yanxi Chemical Co., Ltd.
Product
Piroctone Olamine 68890-66-4
Price
US $85.00/Kg/Drum
Min. Order
25KG
Purity
99%
Supply Ability
20 tons/month
Release date
2020-06-24
BLiT (Hefei)Chemical Co.,Ltd
Product
Piroctone olamine 68890-66-4
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000 TONS
Release date
2024-03-25
Jinan Finer Chemical Co., Ltd
Product
Piroctone olamine 68890-66-4
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
200mt/year
Release date
2022-01-26

68890-66-4, Piroctone olamineRelated Search:

Ciclopirox ethanolamine Monoethanolamine Methylparaben Sodium Pyrithione Pyridine hydrochloride Kresoxim-methyl CHLOROPHOSPHONAZO III Zinc pyrithione 1,2,4-Triazolo[4,3-a]pyridin-3(2H)-one Basic Violet 1 Methyl salicylate Tribenuron methyl Methanol Piroctone Oxybenzone Niclosamide ethanolamine salt Methyl acrylate DIETHANOLAMINE HYDROCHLORIDE

  • 2(1H)-Pyridinone,1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-,compd.with2-aminoethanol(1:1)
  • 4,4-trimethylpentyl)-1-hydroxy-4-methyl-6-(compd.with2-2(1h)-pyridinon
  • octopiroxolamine
  • 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1h)-pyridinoncompd.with2-aminoethanol(1:1)
  • Hydroxyl pyrazole ketones
  • 1-Hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine
  • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)
  • -one compound with 2-aminoethanol (1:1)
  • Ethanolamine salt (1:1)
  • Piroctone olamine Solution, 100ppm
  • PIROCTONE OLAMINE 98.0+%
  • 1-hydroxy-4-methyl-6(2,4,4-trimethylpentyl)2-pyridon monoethanolamine salt
  • OCTOPIROX
  • PIROCTONE OLAMINE
  • Piroctone olamine (OCTO)
  • PIROCTONE OLEAMINE
  • 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
  • Piorctone Olamine
  • 1-HYDROXY-4-METHYL-6-(2,4,4-TRIMETHYLPENTYL)2(1H)-PYRIDONE.
  • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-on, Verbindung mit 2-Aminoethanol (1:1)
  • 1-hydroxy-4-Methyl-6-(2,4,4-triMethylpentyl)pyridin-2(1H)-one-2-aMinoethanol (1:1)
  • Pyridine-aMino ethanol
  • 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2-one
  • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone·2-aminoethanol
  • 2-Aminoethanol/1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone,(1:1)
  • Piroctone Olamine (200 mg)
  • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone ethanolammonium salt
  • PiroCLone olaMine
  • LGB-PO
  • OCTO
  • 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one
  • 4-methyl-1-oxido-6-(2,4,4-trimethylpentyl)-2-pyridinone
  • Piroctone olamine/octopirox
  • Piroctone Olamine &gt
  • Piroctone ethanolamine
  • 2(1H)-Pyridinone, 1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-, compd.with 2-aminoethanol (1:1)OTHER CA INDEX NAMES:Ethanol, 2-amino-, compd. with1-hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridinone (1:1)
  • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)-2(1H)-pyridone Ethanolamine
  • Sinobio Anti Dangdruff Piroctone Olamine Oct for Shampoo CAS?68890-66-4?Octopirox
  • Piroctone Olamine (1544406)
  • Jarguard OCT Piroctone Oleamine
  • 1-Hydroxy-4-methyl-6-(2,4,4-trimethylpentyl)pyridin-2(1H)-one 2-aminoethanol salt
  • Pirotone Oleamine
  • HYDROXYPYRIDINONE（OCT）
  • Piroctone olamine analytical standard, ≥99%
  • 1-HYDROXY-4-METHYL6-(2,4,4-TRI METHYL PHENYL)-2-PYRIDONE MONO ETHANOL AMINE(PIROCTONE OLAMINE)
  • Piroctone Olamine (PO
  • 1-hydroxy-4-methyl-6- (2,4,4-trimethylpentyl)pyridin-2-one (Piroctone olamine)
  • Piroctone ethanolamine salt
  • HYDROXYPYRIDINONE（OCT）/Piroctone olamine
  • 68890-66-4
  • 68890-64-4
  • 951-78-4
  • C14H23NO2C2H7NOC16H30N2O3
  • C14H23NO2C2H7NO
  • C14H23NO2C2H7NOC16H30
  • bacteriostatic and fungistatic
  • ARAMINE
  • OLED materials,pharm chemical,electronic